Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice

Obara, Noriyuki; Fukushima, Koji; Ueno, Yoshiyuki; Wakui, Yuta; Kimura, Osamu; Tamai, Keiichi; Kakazu, Eiji; Inoue, Jun; Kondo, Yasuteru; Ogawa, N.; Sato, Kenta; Tsuduki, Tsuyoshi; Ishida, Kazuyuki; Shimosegawa, Tooru

doi:10.1016/j.jhep.2010.02.029

Cited by 86 publications

(64 citation statements)

References 34 publications

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“…Consequently, when liver-specific SIRT1-null mice are fed a high-fat diet, they develop hepatic steatosis. In addition, they develop signs of ER stress and modest, but significant, increases in hepatic pro-inflammatory cytokines (81). The results are similar to those reported previously in mice with PPARa deficiency (reviewed in (86)).…”

Section: Sirtuins As Master Regulators Of Lipid Synthesis and Oxidationsupporting

confidence: 89%

“…In the deacetylated (active) state, PGC-1a partners with PPARa to promote the transcription of PPARa-dependent genes. Mice with a liver-specific deletion of SIRT1 have impaired PPARa signaling, which results in a reduction in fatty acid oxidation (81). Consequently, when liver-specific SIRT1-null mice are fed a high-fat diet, they develop hepatic steatosis.…”

Section: Sirtuins As Master Regulators Of Lipid Synthesis and Oxidationmentioning

confidence: 99%

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New Insights from Rodent Models of Fatty Liver Disease

Maher

2011

Antioxidants & Redox Signaling

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Rodent models of fatty liver disease are essential research tools that provide a window into disease pathogenesis and a testing ground for prevention and treatment. Models come in many varieties involving dietary and genetic manipulations, and sometimes both. High-energy diets that induce obesity do not uniformly cause fatty liver disease; this has prompted close scrutiny of specific macronutrients and nutrient combinations to determine which have the greatest potential for hepatotoxicity. At the same time, diets that do not cause obesity or the metabolic syndrome but do cause severe steatohepatitis have been exploited to study factors important to progressive liver injury, including cell death, oxidative stress, and immune activation. Rodents with a genetic predisposition to overeating offer yet another model in which to explore the evolution of fatty liver disease. In some animals that overeat, steatohepatitis can develop even without resorting to a high-energy diet. Importantly, these models and others have been used to document that aerobic exercise can prevent or reduce fatty liver disease. This review focuses primarily on lessons learned about steatohepatitis from manipulations of diet and eating behavior. Numerous additional insights about hepatic lipid metabolism, which have been gained from genetically engineered mice, are also mentioned. Antioxid. Redox Signal. 15, 535-550.

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Section: Sirtuins As Master Regulators Of Lipid Synthesis and Oxidationsupporting

confidence: 89%

Section: Sirtuins As Master Regulators Of Lipid Synthesis and Oxidationmentioning

confidence: 99%

New Insights from Rodent Models of Fatty Liver Disease

Maher

2011

Antioxidants & Redox Signaling

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“…Animal models also suggest a role for HCC development with high intake of dietary trans fats and high fructose com syrup [50). Overall, data from human epidemiologic studies and animal models [51) support eliminating trans fats from the human diet, and further ·data are unlikely to change this recommendation given that randomized trials are unethical. On this basis, patients with NAFLD should be advised to mm1m1ze consumption by 228 checking nutritional labels to assess content, which is now 229 mandatory in many countries.…”

Section: Trans Fatty Acidsmentioning

confidence: 99%

Exercise and diet in the management of nonalcoholic fatty liver disease

Mahady

George

2016

Metabolism

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“…However, other than these two diseases, there are numbers of other liver diseases, such as liver cirrhosis, non-alcoholic fatty liver diseases, which are expected to increase in next decades (Kakazu et al 2009;Obara et al 2010;Kakazu et al 2011). Obviously, still more efforts to understand these liver diseases are important to improve global healthcare.…”

Section: Closing Remarksmentioning

confidence: 99%

The Current Endeavors to Understand the Pathogenesis of Intractable Liver Diseases

Ueno

2012

Tohoku J. Exp. Med.

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The death due to liver diseases accounts for more the 35,000 cases every year in Japan for decades. Among these liver diseases, the Ministry of Health, Labor, and Welfare of Japan has named both fulminant hepatitis and primary biliary cirrhosis (PBC) as intractable liver diseases, since the precise mechanism of these diseases are unclear. Accordingly, there are no effective medical treatments other than liver transplantation toward these diseases. However, still the number of the liver transplantation performed in Japan is small. Thus, we have focused on the pathogenesis of these two intractable conditions. The fulminant hepatitis is a distinct form of acute hepatitis, and hepatitis B virus infection accounts for 20~30% of this lethal condition. Only tiny proportions of patients with acute HBV infection develop fulminant hepatitis (less than 10%). It has been widely believed both viral and host factors contribute for fulminant hepatitis, although still unknown factors are expected to be involved. On the other hand, PBC is a chronic progressive cholestatic liver disease. Clinical features of PBC include female predominance (80 to 90%), the presence of antimitochondrial antibody (up to 95%), and elevated serum levels of immunoglobulin M. Eventually, patients with PBC will develop liver failure due to biliary cirrhosis in spite of medical interventions. Immune-mediated processes are believed to be responsible for the pathogenesis, although the precise mechanism is yet to be determined. In this review article, our endeavors to understand the mechanism of these intractable liver diseases are discussed.

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Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice

Cited by 86 publications

References 34 publications

New Insights from Rodent Models of Fatty Liver Disease

New Insights from Rodent Models of Fatty Liver Disease

Exercise and diet in the management of nonalcoholic fatty liver disease

The Current Endeavors to Understand the Pathogenesis of Intractable Liver Diseases

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