Possible interplay between vitamin C deficiency and prolactin in pregnant women with premature rupture of membranes: facts and hypothesis

Casanueva, Esther; Ripoll, Carmina; Meza-Camacho, Carlos; Coutiño, Blanca; Ramírez-Peredo, Jorge; Parra, Adalberto

doi:10.1016/j.mehy.2004.08.002

Cited by 10 publications

(7 citation statements)

References 42 publications

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“…Vitamin C supplementation has been shown in some studies to reduce the risk of premature rupture of placental membranes and premature births, gestational hypertension, intrauterine growth retardation, and gestational diabetes in addition to other health benefits. [ 5 6 7 8 9 ] Furthermore, because Vitamin C enhances iron absorption,[ 10 11 ] the low serum ascorbate can lead to a decrease in the absorption and subsequent utilization of iron which is required for the proper maintenance of pregnancy and fetal growth.…”

Section: Introductionmentioning

confidence: 99%

Low serum Vitamin C status among pregnant women attending antenatal care at general hospital Dawakin Kudu, Northwest Nigeria

2016

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Background:Vitamin C levels are low in pregnancy. The purpose of this study was to determine serum Vitamins C levels among pregnant women attending antenatal care at a General Hospital in Dawakin Kudu, Kano, and this can help further research to determine the place of Vitamin C supplementation in pregnancy.Methods:This was a prospective study of 400 pregnant women who presented for antenatal care in General Hospital Dawakin Kudu, Kano, Nigeria. Research structured questionnaire was administered to 400 respondents. Determination of serum Vitamin C was done using appropriate biochemical methods.Results:Vitamin C deficiency was found in 79.5% of the participants. The values for Vitamin C were 0.20 ± 0.18 mg/dl during the first trimester, 0.50 ± 0.99 mg/dl in the second trimester, and 0.35 ± 0.36 mg/dl in the third trimester and P = 0.001.Conclusions:There is a significant reduction in the serum Vitamins C concentration throughout the period of pregnancy with the highest levels in the second trimester. Therefore, Vitamin C supplementation is suggested during pregnancy, especially for those whose fruit and vegetable consumption is inadequate.

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Section: Introductionmentioning

confidence: 99%

Low serum Vitamin C status among pregnant women attending antenatal care at general hospital Dawakin Kudu, Northwest Nigeria

2016

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“…In this regard, it has been suggested that the increased local PRL concentration (acting like Th1‐type cytokine) along with overexpression of other proinflammatory cytokines would induce a premature switch from a favorable Th2‐type immune response to a noxious Th1‐type in the intrauterine environment. These changes plus vitamin C deficiency and upregulation of matrix metalloproteinases favors PRM 8 . Therefore, BRC, directly (decreasing PRL concentration) or indirectly (through its immunomodulator properties), may prevent PRM.…”

Section: Discussionmentioning

confidence: 99%

“…These changes plus vitamin C deficiency and upregulation of matrix metalloproteinases favors PRM. 8 Therefore, BRC, directly (decreasing PRL concentration) or indirectly (through its immunomodulator properties), may prevent PRM.…”

Section: Discussionmentioning

confidence: 99%

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Bromocriptine during Pregnancy in Systemic Lupus Erythematosus

Jara¹,

Cruz-Cruz²,

Saavedra³

et al. 2007

Annals of the New York Academy of Sciences

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Bromocriptine (BRC) prevents postpartum flare in lupus patients. However, its potential role in protecting lupus pregnancy from maternal-fetal complications has not been studied. The objective of the study was to explore the role of oral BRC during pregnancy in patients with systemic lupus erythematosus (SLE). Pregnant SLE patients were randomized into two groups: group 1 received BRC 2.5 mg/day and prednisone 10 mg/day; group 2 received prednisone 10 mg/day. These treatments were administered from 25 to 35 weeks of gestation. Prolactin (PRL) levels were determined at 25, 30, and 35 weeks. The SLE Pregnancy Disease Activity Index, maternal-fetal outcome including preterm birth, fetal loss, premature rupture of membrane (PRM), low birth weight, and preeclampsia/eclampsia were evaluated. We studied 20 patients (10 in each group). A significant decrease of PRL levels in group 1 compared to group 2 at week 30 and at week 35 was found. No patients in the BRC group had flares and three from group 2 had SLE activity. None of the patients in group 1 had PRM but three patients in group 2 did. Eighty percent of pregnancies ended in birth at term in group 1 and 50% in group 2. There was no fetal loss in both groups. Mean birth weight was higher in group 1 than in group 2 (P < NS). BRC was well tolerated. This is the first clinical trial of BRC in SLE pregnancy. Our pilot study suggests that BRC may play a role in the prevention of maternal-fetal complications, such as PRM, preterm birth, and active disease.

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“…When the expression of MMP-2 increases, collagen degradation in human skin is increased (Steinbrenner, Ramos, Stuhlmann, Sies, & Brenneisen, 2003), leading to wrinkle formation and aged appearance. Thus, many MMP-2 inhibitors such as vitamin C and vitamin E (Casanueva et al, 2005) have been incorporated in functional foods and anti-aging cosmetics.…”

Section: Introductionmentioning

confidence: 99%

Relationship between biological activities and bioactive compounds in the fermented rice sap

Manosroi

Ruksiriwanich

Kietthanakorn³

et al. 2011

Food Research International

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Possible interplay between vitamin C deficiency and prolactin in pregnant women with premature rupture of membranes: facts and hypothesis

Cited by 10 publications

References 42 publications

Low serum Vitamin C status among pregnant women attending antenatal care at general hospital Dawakin Kudu, Northwest Nigeria

Low serum Vitamin C status among pregnant women attending antenatal care at general hospital Dawakin Kudu, Northwest Nigeria

Bromocriptine during Pregnancy in Systemic Lupus Erythematosus

Relationship between biological activities and bioactive compounds in the fermented rice sap

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