Low serum Vitamin C status among pregnant women attending antenatal care at general hospital Dawakin Kudu, Northwest Nigeria

Ugwa, Emmanuel Ajuluchukwu; Iwasam, Elemi Agbor; Nwali, Matthew Igwe

doi:10.4103/2008-7802.176166

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…The mean serum of vitamin C showed a significantly lower concentration in the third trimester compared with the control. This is consistent with earlier studies in which low vitamin C levels were reported in pregnancy [15]. The reason for the significantly lower levels during pregnancy compared with the nonpregnant state is not clear but is consistent with the postulation that uteroplacental perfusion [16] induces oxidative stress and ascorbate consumption [17,18].…”

Section: Resultssupporting

confidence: 92%

Birth Weight and Third-trimester Maternal Vitamins A, C, and E Levels

Joseph,

Oyediran,

Oladiti

et al. 2024

AJRIMPS

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Background: Deficiencies of micronutrients (especially vitamins C, A, and E) during intra-uterine life have been linked with the possibility of increased risk of some diseases (e.g. cardiovascular disease and type 2 diabetes) in adulthood. Aims: Therefore, it becomes expedient that persistent and vigorous attention be paid to maternal vitamin status during gestation. Methodology: This is a cross-sectional comparative study carried out at maternity centres in Osogbo Local Government. Forty women who were at least 29 weeks of gestation and 40 apparently healthy women, age-matched, non-pregnant constituted the test and control groups respectively. Blood was obtained through an ante-cubital vein, centrifuged and used for vitamin estimations (High-Performance Liquid Chromatography). Birth weight and neonatal mortality ratio were the birth outcomes that were obtained. Data analysis was by Student’s t-test and Pearson’s correlation coefficient. P≤0.05 was considered significant. Results: Serum status of vitamins A (2.68±3.88 µg/dL); C (0.95±0.44 mg/dL); and E (0.67±0.04 mg/dL) were significantly lower at third trimester compared with the corresponding values of 6.98±1.26 µg/dL; 2.99±0.11 mg/dL; and 1.66±0.08 mg/dL among non-pregnant control. There were significant adverse pregnancy outcomes as signified by 10% stillbirths. In addition, low birth weight (1.5-2.4 kg) was observed among approximately 50% of the babies but no correlation was observed except between vitamins C and E. Conclusions: The results of this study revealed that among Nigerian pregnant women, there are risks of abnormal birth outcomes and low levels of vitamin A, C, and E. Aside depletions in vitamin C and E, the results of the study (r= .376; p= .020) suggest possible metabolic interaction between both.

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Section: Resultssupporting

confidence: 92%

Birth Weight and Third-trimester Maternal Vitamins A, C, and E Levels

Joseph,

Oyediran,

Oladiti

et al. 2024

AJRIMPS

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“…Similar results have been found in pregnant women in other African settings. In North-West Nigeria there was an 80% prevalence of hypovitaminosis C in 400 pregnant women in a study conducted in 2009 (Ugwa et al, 2016). In this study, the mean vitamin C levels was 20 μmol/L, very similar to our data.…”

Section: Discussionsupporting

confidence: 90%

Vitamin C levels in a Central‐African mother–infant cohort: Does hypovitaminosis C increase the risk of enteric infections?

Moya-Alvarez

Koyembi

Kayé

et al. 2021

Maternal & Child Nutrition

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In the MITICA (Mother-to-Infant TransmIssion of microbiota in Central-Africa) study, 48 mothers and their 50 infants were followed from delivery to 6 months between December 2017 and June 2019 in Bangui (Central-African Republic). Blood tests and stool analyses were performed in mothers at delivery, and their offspring at birth, 11 weeks and 25 weeks. Stool cultures were performed in specific growth media for Salmonella, Shigella, E. coli, Campylobacter, Enerobacter, Vibrio cholerae, Citrobacter and Klebsiella, as well as rotavirus, yeasts and parasitological exams. The median vitamin C levels in mothers at delivery were 15.3 μmol/L (inter-quartile-range [IQR] 6.2-27.8 μmol/L). In infants, the median vitamin C levels at birth were 35.2 μmol/L (IQR 16.5-63.9 μmol/L). At 11 and 25 weeks, the median vitamin C levels were 41.5 μmol/L (IQR 18.7-71.6 μmol/L) and 18.2 μmol/L (IQR 2.3-46.6 μmol/L), respectively. Hypovitaminosis C was defined as seric vitamin C levels <28 μmol/L and vitamin C deficiency was defined as vitamin C levels <11 μmol/L according to the WHO definition. In mothers, the prevalence of hypovitaminosis-C and vitamin C deficiency

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“…A number of small studies have been carried out in Nigerian women. One study of 400 antenatal clinic patients showed low vitamin C status (20 ± 29 µmol/L) with 80% of the women exhibiting hypovitaminosis C [ 49 ]. The authors attributed this to high parity, inadequate nutrition and nutritional taboos among Northern Nigerian females.…”

Section: Global Vitamin C Status and Prevalence Of Insufficiencymentioning

confidence: 99%

Global Vitamin C Status and Prevalence of Deficiency: A Cause for Concern?

2020

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Vitamin C is an essential nutrient that must be obtained through the diet in adequate amounts to prevent hypovitaminosis C, deficiency and its consequences—including the potentially fatal deficiency disease scurvy. Global vitamin C status and prevalence of deficiency has not previously been reported, despite vitamin C’s pleiotropic roles in both non-communicable and communicable disease. This review highlights the global literature on vitamin C status and the prevalence of hypovitaminosis C and deficiency. Related dietary intake is reported if assessed in the studies. Overall, the review illustrates the shortage of high quality epidemiological studies of vitamin C status in many countries, particularly low- and middle-income countries. The available evidence indicates that vitamin C hypovitaminosis and deficiency is common in low- and middle-income countries and not uncommon in high income settings. Further epidemiological studies are required to confirm these findings, to fully assess the extent of global vitamin C insufficiency, and to understand associations with a range of disease processes. Our findings suggest a need for interventions to prevent deficiency in a range of at risk groups and regions of the world.

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Low serum Vitamin C status among pregnant women attending antenatal care at general hospital Dawakin Kudu, Northwest Nigeria

Cited by 7 publications

References 21 publications

Birth Weight and Third-trimester Maternal Vitamins A, C, and E Levels

Birth Weight and Third-trimester Maternal Vitamins A, C, and E Levels

Vitamin C levels in a Central‐African mother–infant cohort: Does hypovitaminosis C increase the risk of enteric infections?

Global Vitamin C Status and Prevalence of Deficiency: A Cause for Concern?

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