Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan

Wang, Tso Jen; Huang, San Yuan; Lin, Wei; Lo, Hsin Yi; Wu, Pei Lin; Wang, Yu Shan; Wu, Yi; Ko, Huei Chen; Shih, Jean C.; Lu, Ru‐Band

doi:10.1016/j.pnpbp.2006.08.010

Cited by 35 publications

(33 citation statements)

References 65 publications

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“…Wang et al 85 investigated this same gene interaction in antisocial personality disorder individuals, with or without alcoholism and found no association between MAOA-mVNTR polymorphism or TaqI A and this personality disorder. However, among subjects with the 4-repeat allele, the frequency of the DRD2 A1/A2 genotype…”

Section: Alcohol Dependencementioning

confidence: 99%

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Nishioka¹,

Perin²,

Sampaio³

et al. 2011

Rev. psiquiatr. clín.

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Introduction: A functional variable number of tandem repeats (VNTR) polymorphism of the promoter region of the monoamine oxidase A (MAOA) gene has been described and many studies have investigated the association of this polymorphism with human behaviors, as well as with several psychiatric disorders. Objective: This study aimed to review the literature on the role of the VNTR functional polymorphism of the promoter region of the MAOA gene on the modulation of human behavior for the development of psychiatric disorders. Method: Searches on the Medline, Embase, Web of Science and PsycInfo databases were performed including works from January 1998 to June 2009. The words used were: "MAOA and human behavior" and "MAOA and psychiatry". Results: Several studies were found (N = 3,873). After the selection process, 109 papers were included in the review. There was found an association of MAOA low activity alleles with antisocial personality disorder, conduct disorder, ADHD, pathological gambling, and substance abuse. High activity alleles were associated with neuroticism, anorexia nervosa and depression and anxiety disorders. There was no association between the MAOA polymorphisms and bipolar disorder and schizophrenia. Discussion: The main findings, summarized in this paper, support a role of MAOA VNTR polymorphism in some psychiatric disorders although some divergences were found due to methodological difficulties in genetic studies. In general, the studies associated the low activity alleles with impulsivity and aggressive behavior ("hyperactive behaviors"), and the high activity alleles of the gene with "hypoactive behaviors", such as depression and anxiety, which demonstrates a modulation of the MAOA enzyme in "hyperactive" and "hypoactive" disorders.

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Section: Alcohol Dependencementioning

confidence: 99%

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Nishioka¹,

Perin²,

Sampaio³

et al. 2011

Rev. psiquiatr. clín.

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“…A recent study suggested that the possible interactions between the MAOA and DRD2 genes might be related to antisocial personality disorder with alcoholism among Taiwanese [33]. Future research should further investigate the contributions of the MAOA gene to personality traits in antisocial personality disorder with alcoholism.…”

Section: Antisocial Personality Disorder With Alcoholismmentioning

confidence: 97%

Molecular Genetics of Human Personality Traits for Psychiatric, Behavioral, and Substance-Related Disorders

Lin¹,

Chen²

2009

TOTRANSMJ

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Abstract:The investigation of personality genetics had received much attention since the three seminal reports showing an association between genes and personality traits in the general population. Accumulating evidences suggested that personality traits have significant genetic components. Although currently available data are not enough for proof, more and more genetic variants associated with personality traits are being discovered. In this paper, we review related studies of gene polymorphisms and human personality traits for psychiatric, behavioral, and substance-related disorders. First, we briefly describe the commonly-used self-reported temperament measures that define personality dimensions. Then, we summarize the characteristics of the candidate genes for personality traits, and investigate gene variants which have been suggested to be linked with personality traits for individuals with psychiatric, behavioral, and substance-related disorders.

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“…A variant of the tyrosine hydroxylase enzyme, which is involved in the synthesis of dopamine, is associated with early-onset alcoholism (Dahmen, Volp, Singer, Hiemke & Szegedi, 2005). Besides, certain variants in the genes encoding for dopamine metabolizing enzyme monoamine oxidase A and the dopamine D2 receptor are associated with the emergence of antisocial personality traits and a higher proneness for alcoholism (Parsian, 1999;T. J. Wang et al, 2007).…”

Section: Dopaminergic Systemmentioning

confidence: 99%

Alteraciones neurobiológicas en el alcoholismo: revisión

Erdozain

Callado

2014

Adicciones

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The exact mechanism by which ethanol exerts its effects on the brain is still unknown. However, nowadays it is well known that ethanol interacts with specific neuronal membrane proteins involved in signal transmission, resulting in changes in neural activity. In this review different neurochemical alterations produced by ethanol are described. Primarily, ethanol interacts with two membrane receptors: GABA A and NMDA ion channel receptors. Ethanol enhances the GABA action and antagonizes glutamate action, therefore acting as a CNS depressant. In addition, ethanol affects most other neurochemical and endocrine systems. In regard to the brain reward system, both dopaminergic and opioid system are affected by this drug. Furthermore, the serotonergic, noradrenergic, corticotropinreleasing factor and cannabinoid systems seem to play an important role in the neurobiology of alcoholism. At last but not least, ethanol can also modulate cytoplasmic components, including the second messengers. We also review briefly the different actual and putative pharmacological treatments for alcoholism, based on the alterations produced by this drug.

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Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan

Cited by 35 publications

References 65 publications

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Molecular Genetics of Human Personality Traits for Psychiatric, Behavioral, and Substance-Related Disorders

Alteraciones neurobiológicas en el alcoholismo: revisión

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