Possible implication of miR-142-3p in coronary microembolization induced myocardial injury via ATXN1L/HDAC3/NOL3 axis

Xu, Yu; Lv, Xiangwei; Cai, Ruping; Ren, Yi; He, Shirong; Zhang, Wei; Li, Quanzhong; Yang, Xiheng; Dai, Rixin; Wei, Riming; Su, Qiang

doi:10.1007/s00109-022-02198-z

Cited by 10 publications

(3 citation statements)

References 44 publications

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“…BNC2, a cell type-specific zinc finger protein, is related to color changes and the development of several types of cancer [39]. BNC2 is highly expressed in the fetal heart and penis [40] and is downregulated in myocardial ischemia models [41]. Although there is no direct evidence of the biological function of RNF135 and BNC2 in ischemic injury, both genes may exert cardioprotective effects induced by anesthesia by modulating oxidative phosphorylation in the heart under OPCABG.…”

Section: Discussionmentioning

confidence: 99%

Identification of Anesthetic-Induced Cardiovascular Biomarkers in Off-Pump Coronary Artery Bypass Grafting Surgery Using Weighted Gene Co-Expression Network Analysis and Machine Learning

Hou,

2023

HSF

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Background: This study aimed to select anesthesia-induced zinc finger protein-related gene biomarkers that predict cardiovascular function during off-pump coronary artery bypass grafting (OPCABG). Methods: Gene expression data from GSE4386 included 20 post-anesthesia and 20 pre-anesthesia atrial tissue samples. Zinc finger protein-related genes (ZFPRGs) were searched in the UniProt database and anesthesia-induced differentially expressed genes (DEGs) were identified Weighted gene co-expression network analysis (WGCNA) was used to screen hub genes, and three machine learning algorithms were used to further screen for cardiovascular biomarkers. Diagnostic accuracy was evaluated using a nomogram model. Gene set enrichment analysis was used to analyze the pathways enriched by the biomarkers. A microRNA (miRNA)-mRNA-transcription factor (TF) regulatory network was established to explore the potential regulatory mechanisms of these biomarkers. Disease-related drugs were predicted using the Comparative Toxicogenomics Database (CTD). Results: A total of 1102 cardioprotection-related DEGs were selected between the pre- and post-anesthesia groups. Additionally, 1095 hub genes were obtained based on WGCNA, and 2274 ZFPRGs were downloaded from the UniProt database. After Venn analysis and machine learning, ZNF420, RNF135, and BNC2 were selected as cardioprotection-related zinc finger biomarkers during OPCABG. Receiver operating characteristic (ROC) curves and nomogram models confirmed the diagnostic value and accuracy of the three cardioprotective biomarkers. Pathway enrichment analysis revealed that ZNF420 is involved in the cell cycle and the tricarboxylic acid cycle. RNF135 and BNC2 were enriched in the oxidative phosphorylation pathway. In the constructed miRNA-mRNA-TF network, miR-182-5p and miR-16-5p simultaneously regulated three cardioprotective biomarkers. Conclusion: Three cardioprotection-related zinc finger protein biomarkers (ZNF420, RNF135, and BNC2) were identified using OPCABG samples.

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Section: Discussionmentioning

confidence: 99%

Identification of Anesthetic-Induced Cardiovascular Biomarkers in Off-Pump Coronary Artery Bypass Grafting Surgery Using Weighted Gene Co-Expression Network Analysis and Machine Learning

Hou,

2023

HSF

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“…Chen et al have found that miR-200a-3p decreases after CME; consequently, myocardial injury induced by CME is ameliorated through inhibition of the TXNIP/ NLRP3 axis, the inflammatory response, and oxidative stress [19]. Xu et al have found that overexpression of miR-142-3p targets ATXN1L, thus decreasing myocardial injury after CME, and that ATXN1L binds HDAC3, thus promoting histone 3 deacetylation and consequently inhibiting NOL3 expression, promoting caspase-1/IL-1β/IL-18 signaling, and inducing myocardial injury [15]. Kong et al have found that miR-26a-5p is downregulated after CME; this miRNA binds HMGA1 mRNA and regulates the HMGA1/nuclear factor kappa-B (NF-κB)/TNF-α pathway, thus ameliorating myocardial inflammation and injury after CME as Bcl-2, B-cell lymphoma-extra-large (Bcl-xl), and Bcl-2-like protein 2 (Bcl-w), inhibit the activity of pro-apoptotic factors by binding Bcl-2 homology motif (BH3)-only and Bak proteins.…”

Section: Roles Of Mirnas In the Inflammatory Response After Cmementioning

confidence: 99%

Advances in MicroRNA-Mediated Regulation of Cardiomyocyte Injury After Coronary Microembolization

Li,

Zheng,

et al. 2024

CVIA

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Coronary microembolization (CME) occurs in patients with acute coronary syndrome and is caused primarily by atherosclerotic plaque rupture associated with surgery. CME can lead to arrhythmias, decreased coronary blood flow reserve, and cardiac systolic dysfunction. The clinical efficacy of conventional coronary artery dilation, antiplatelet agents, and direct thrombus aspiration after CME is not satisfactory. Studies have indicated that microRNAs (miRNAs) specifically bind the 3′ untranslated regions (UTRs) of inflammatory response-, apoptosis-, and autophagy-related mRNAs, and ultimately affect CME prognosis. In-depth studies of the roles of miRNAs in CME occurrence and development would not only advance understanding of the mechanisms underlying poor prognosis after CME but also aid in identifying new targets for drug treatment. Here, we review the regulatory effects of miRNAs on myocardial cell injury after CME in terms of the inflammatory response, apoptosis, and autophagy. Overall, changes in miRNA levels after CME decrease myocardial autophagy and worsen cardiac prognosis. Current evidence suggests a potential strategic pathway for therapeutic intervention in CME management.

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“… 20 Among them, miR-142-3p was involved in the occurrences and progression of various cardiovascular diseases. 21 , 22 , 23 Previous studies found that miR-142-3p upregulation could ameliorate myocardial ischemia/reperfusion (I/R)-induced transdifferentiation of fibroblasts to myofibroblasts and collagen deposition. 24 , 25 Also, in addition to playing a role in the development of various cancers, 22 , 26 miR-142-3p-mediated autophagy was reported as a novel mechanism toward I/R-induced cardiac injure.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy

Li,

Zhao,

et al. 2024

iScience

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Possible implication of miR-142-3p in coronary microembolization induced myocardial injury via ATXN1L/HDAC3/NOL3 axis

Cited by 10 publications

References 44 publications

Identification of Anesthetic-Induced Cardiovascular Biomarkers in Off-Pump Coronary Artery Bypass Grafting Surgery Using Weighted Gene Co-Expression Network Analysis and Machine Learning

Identification of Anesthetic-Induced Cardiovascular Biomarkers in Off-Pump Coronary Artery Bypass Grafting Surgery Using Weighted Gene Co-Expression Network Analysis and Machine Learning

Advances in MicroRNA-Mediated Regulation of Cardiomyocyte Injury After Coronary Microembolization

MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy

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