Possible Function of Urinary pH and Citrate on the Ceftriaxone-induced Nephrolithiasis

Cong, Xiaoming; Gu, Xiaoqing; Sun, Xu; Ning, Benxiang; Shen, Lan

doi:10.1016/j.urology.2013.09.029

Cited by 11 publications

(12 citation statements)

References 13 publications

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“…A recent study has suggested that urinary pH and citrate are probable factors for Ceftriaxone‐induced nephrolithiasis. Alkaline urine and hypocitraturia predispose ceftriaxone nephrolithiasis, and in line with this, acidifying urine could dissolve ceftriaxone‐induced stones …”

Section: Resultsmentioning

confidence: 87%

“…While, one stone persisted up to 9 months after treatment. The time for spontaneous elimination of ceftriaxone associated renal stones ranged from 5 days to 3 weeks in previously reported cases . In 2004 Avci et al observed that the times for spontaneous elimination of calculi in their study were longer than those of previously reported cases.…”

Section: Resultsmentioning

confidence: 88%

“…The time for spontaneous elimination of ceftriaxone associated renal stones ranged from 5 days to 3 weeks in previously reported cases. [12][13][14][15][16][17][18][19][20] In 2004 Avci et al 1 observed that the times for spontaneous elimination of calculi in their study were longer than those of previously reported cases. This was explained by the location of the stones that may have been responsible for this observation, as in three cases calculi were located in the lower pole of the kidney.…”

Section: Nephrolithiasis In Children Receiving Cefotri Ceftriaxone Axonementioning

confidence: 99%

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Prospective study of nephrolithiasis occurrence in children receiving cefotriaxone

et al. 2016

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Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 88%

Section: Nephrolithiasis In Children Receiving Cefotri Ceftriaxone Axonementioning

confidence: 99%

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Prospective study of nephrolithiasis occurrence in children receiving cefotriaxone

et al. 2016

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“…It is assumed that the mechanism of formation of pulp stones is similar to that of calcifications occurring in other organs in the body (Carson, 1998). A study showed that kidney stones may form due to an increase in urinary pH, and high alkalinity of urine is a strong indicator of urolithiasis (Cong et al, 2014). Interestingly, a recent meta-analysis reported an association between pulp and kidney stones (Gabardo et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Sialometric and Sialochemical Analysis in Individuals With Pulp Stones

Gabardo

Kublitski

Sette

et al. 2020

Front. Cell Dev. Biol.

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The aim of this study was to analyze the saliva of patients with pulp stones, with sialometric and sialochemical tests. Eighty individuals, aged between18 and 65 years, of both sexes, were investigated. Patients were included in the pulp stone group when radiographic examination was suggestive of pulp stones in at least one permanent tooth, whereas those without this alteration were considered controls. Saliva was collected by stimulation, followed by salivary flowrate (SFR) and pH analysis tests. The organic components, such as urea (URE), glucose (GLU), total proteins (TPTs), alkaline phosphatase, creatinine (CRE), salivary amylase (SAM), and uric acid (URA), and the inorganic components, such as calcium, iron, and phosphorus, were evaluated by colorimetric techniques in an ultraviolet-visible (UV-vis) spectrophotometer. Differences among pulp stones and control groups were compared using Student's t-test, with a significance level of p < 0.05. In both groups prevailed the female. Statistically significant differences between groups were observed for pH (p = 0.027), SFR (p = 0.002), alkaline phosphatase (p = 0.008), and URA (p = 0.005). None of the inorganic components showed significant difference (p > 0.05). In the analyses stratified by sex, difference between groups was observed for pH (p = 0.007) and URA (p = 0.003) in women. In conclusion, sialometric and sialochemical alterations occurred in patients with pulp stones, with significantly higher levels of pH, SFR, alkaline phosphatase, and URA.

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“…Several risk factors for ceftriaxone-induced nephrolithiasis have been discussed in the literature, including a positive family history of stones, high dosage (> 100 mg/kg/ day), rapid infusion rates (< 30 min), and dehydration [27]. Furthermore, Cong et al [47] used an in vitro crystallization model to illustrate that ceftriaxone-induced crystallization was significantly decreased by lowering the urinary pH or increasing the urinary citrate level. In this setting, the dosage of ceftriaxone ranged from 50 to 100 mg/kg/day in the included studies, while the ceftriaxone-induced stone developed after 2 [28] to 16 [41] days.…”

Section: Pathophysiologymentioning

confidence: 99%

Drug-Induced Urolithiasis in Pediatric Patients

et al. 2019

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Drug-induced nephrolithiasis is a rare condition in children. The involved drugs may be divided into two different categories according to the mechanism involved in calculi formation. The first one includes poorly soluble drugs that favor the crystallization and calculi formation. The second category includes drugs that enhance calculi formation through their metabolic effects. The diagnosis of these specific calculi depends on a detailed medical history, associated comorbidities and the patient's history of drug consumption. There are several risk factors associated with drug-induced stones, such as high dose of consumed drugs and long duration of treatment. Moreover, there are some specific risk factors, including urinary pH and the amount of fluid consumed by children. There are limited data regarding pediatric lithogenic drugs, and hence, our aim was to perform a comprehensive review of the literature to summarize these drugs and identify the possible mechanisms involved in calculi formation and discuss the management and preventive measures for these calculi.

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Possible Function of Urinary pH and Citrate on the Ceftriaxone-induced Nephrolithiasis

Cited by 11 publications

References 13 publications

Prospective study of nephrolithiasis occurrence in children receiving cefotriaxone

Prospective study of nephrolithiasis occurrence in children receiving cefotriaxone

Sialometric and Sialochemical Analysis in Individuals With Pulp Stones

Drug-Induced Urolithiasis in Pediatric Patients

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