Drug-Induced Urolithiasis in Pediatric Patients

Sighinolfi, Maria Chiara; Eissa, Ahmed; Bevilacqua, L.; Zoeir, Ahmed; Ciarlariello, S.; Morini, Elena; Puliatti, Stefano; Durante, Viviana; Ceccarelli, Pier Luca; Micali, Salvatore; Bianchi, Giampaolo

doi:10.1007/s40272-019-00355-5

Cited by 15 publications

(16 citation statements)

References 122 publications

(266 reference statements)

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“…From a general point of view, drugs may be divided into two different categories according to the mechanism involved in calculi formation [5,122]. The first one includes poorly soluble drugs that favor crystallization and calculi formation.…”

Section: Discussionmentioning

confidence: 99%

Drug-induced nephrolithiasis and crystalluria: the particular case of the sulfasalazine derivatives

Chebion¹,

Bugni²,

Gérin³

et al. 2022

Comptes Rendus. Chimie

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Introduction: Drug-induced calculi are rarely reported in literature but represent a seldom reported complication of long-term or high-dose prescription of certain medications. We review here some drugs involved in stone formation from first case reports of sulfonamides in the 1930s to protease inhibitors and sulfadiazine with more recent emergence of HIV and opportunistic infections. Finally, we will study in particular sulfasalazine and mesalazine, two different forms of a drug used for treatment of ulcerative colitis or Crohn's disease.Material and methods: Review of the literature and report of a series of ten new cases of mesalazineinduced nephrolithiasis.Results and discussion: Ten patients (eight women and two men) produced stones spontaneously passed (n = 9) or surgically removed (n = 1). Patients received mesalazine either for ulcerative colitis (n = 6) or Crohn's disease (n = 4). The daily oral dose was 4 g/d in nine patients and only 2 g/d in one subject. The duration of medication before stone episode ranged from one month up to 15 years with an average of four years. Stone analysis found pure mesalazine in all stones analyzed (n = 9). Rod-shaped crystals found in urine of one patient (stone unavailable) were identified as mesalazine by Fourier transform infrared spectroscopy.

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Section: Discussionmentioning

confidence: 99%

Drug-induced nephrolithiasis and crystalluria: the particular case of the sulfasalazine derivatives

Chebion¹,

Bugni²,

Gérin³

et al. 2022

Comptes Rendus. Chimie

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“…Drugs regarded as being associated with an increased risk of the ability to form intrarenal crystal deposition mostly include sulphonamides, triamterene, antiretroviral drugs used in HAART therapy (delavirdine, efavirenz, nevirapine, and rilpivirine), antacids (magnesium trisilicate, aluminum hydroxide), methotrexate, quinolones (ciprofloxacin, norfloxacin), and some antibiotics (e.g., ampicillin, amoxicillin) [ 10 , 17 , 18 , 19 , 20 , 21 ]. Detailed information on the etiopathogenesis of drug-related nephrolithiasis, with particular emphasis on the specific types of drug-induced stones, is beyond the scope of this study and can be found in the detailed reviews on this subject [ 59 , 60 , 61 ]. It should be emphasized that apart from drug-induced kidney stones, developing as a result of the direct precipitation of drugs and their metabolites in the urinary tract, other indirect “metabolic, drug-related stones” may be distinguished.…”

Section: Mechanisms Of Drug Nephrotoxicity and Examples Of Offending ...mentioning

confidence: 99%

A Synopsis of Current Theories on Drug-Induced Nephrotoxicity

Dobrek

2023

Life

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The overriding goal of the treatment of patients is its effectiveness and safety. However, all medications currently being used also exert some adverse pharmaceutical reactions, which may be regarded as an unintended but inevitable cost of pharmacotherapy. The kidney, as the main organ that eliminates xenobiotics, is an organ especially predisposed and vulnerable to the toxic effects of drugs and their metabolites during their excretion from the body. Moreover, some drugs (e.g., aminoglycosides, cyclosporin A, cisplatin, amphotericin B, and others) have a “preferential” nephrotoxicity potential, and their use is associated with an increased risk of kidney damage. Drug nephrotoxicity is, therefore, both a significant problem and a complication of pharmacotherapy. It should be noted that, currently, there is no generally recognized definition of drug-induced nephrotoxicity and no clear criteria for its diagnosis. This review briefly describes the epidemiology and diagnosis of drug-induced nephrotoxicity and characterizes its pathomechanisms, including immunological and inflammatory disturbances, altered kidney blood flow, tubulointerstitial injury, increased lithogenesis–crystal nephropathy, rhabdomyolysis, and thrombotic microangiopathy. The study also lists the basic drugs with nephrotoxicity potential and provides a short overview of the preventive methods for reducing the risk of drug-related kidney damage developing.

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“…), intestinal malabsorption, or infection. 73 , 74 Thorough medical history and clinical testing are the only means to identify the cause of secondary kidney stones. Treating the etiology and giving the above preventive measures can effectively reduce the recurrence of calculi.…”

Section: Prevention Of Hereditary and Secondary Calculimentioning

confidence: 99%

The current status of preventive measures for urinary calculi in children

Zhong

Huang

Yang

et al. 2021

Therapeutic Advances in Urology

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Urological calculus is a common disease in urology. Urological calculi are generally more common in adults but have become more common in children in recent years. Most existing studies focus on the prevention of urinary calculi in adults; there are relatively few articles on calculi in children. Reported preventive measures are not comprehensive enough, while the latest research progress has not been updated. The pathogenesis and preventive measures associated with urinary calculi have been the focus of research, but many preventive measures still need further clarification. This article reviews the progress on preventive measures for urinary calculi in children.

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Drug-Induced Urolithiasis in Pediatric Patients

Cited by 15 publications

References 122 publications

Drug-induced nephrolithiasis and crystalluria: the particular case of the sulfasalazine derivatives

Drug-induced nephrolithiasis and crystalluria: the particular case of the sulfasalazine derivatives

A Synopsis of Current Theories on Drug-Induced Nephrotoxicity

The current status of preventive measures for urinary calculi in children

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