Possible Effect of Pigment on the Pharmacokinetics of Ofloxacin and Its Excretion in Hair

Uematsu, Toshihiko; Miyazawa, Norio; Okazaki, Osamu; Nakashima, Mitsuyoshi

doi:10.1002/jps.2600810109

Cited by 61 publications

(26 citation statements)

References 12 publications

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“…Numerous studies have confirmed that melanin pigments play an important role in the incorporation of drugs into hair (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). This may lead to a hair color bias in the interpretation of hair testing results.…”

mentioning

confidence: 92%

Relationship of Melanin Degradation Products to Actual Melanin Content: Application to Human Hair

Borges

Roberts

Wilkins

et al. 2001

Analytical Biochemistry

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mentioning

confidence: 92%

Relationship of Melanin Degradation Products to Actual Melanin Content: Application to Human Hair

Borges

Roberts

Wilkins

et al. 2001

Analytical Biochemistry

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“…Concentrations of haloperidol found in human hair are in proportion to the daily dose and plasma AUC (Matsuno et al, 1990;Uematsu et al, 1988Uematsu et al, , 1992b. In contrast, the concentration of ofloxacin in rat hair was correlated more closely with plasma Cmax than dose or AUC partly because ofloxacin exhibits non-linear pharmocokinetics in rats (Uematsu et al, 1992a). From this finding, we suggest that ofloxacin which has a high affinity for melanin, might be incorporated into hair bulb cells in proportion to maximum blood drug concentration.…”

Section: Discussionmentioning

confidence: 74%

The measurement of a new antimicrobial quinolone in hair as an index of drug exposure.

Nakano

Akiyama

Nakashima

1993

Brit J Clinical Pharma

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1. Scalp hair samples were obtained at 1 month intervals up to 5 months from healthy male volunteers participating in a phase I study of a new antimicrobial quinolone, OPC‐17116. 2. Hair was sectioned into 1 cm lengths from the scalp end. Corresponding portions from five pieces of hair were dissolved in 1 N NaOH and assayed for OPC‐17116 by h.p.l.c. 3. In all subjects taking a single dose (400 mg, n = 5) or repeated doses (400 mg day‐1, twice daily, for 6.5 days, n = 6), the drug was detected in the portions of hair corresponding to the administration period, assuming a hair growth rate of 1 cm/month. 4. OPC‐17116 (300 mg day‐1, three times daily, for 2 days) was given to four healthy male volunteers, from whom hair samples were obtained at 1 month and 3 months. The drug was detected in 1 to 4 consecutive 2.5‐mm long portions of a single hair and there was no significant axial diffusion of the agent along the hair shaft with time. 5. These findings indicate the utility of measuring this quinolone derivative in hair as an index of exposure, and as a time‐marker for the hair analysis of other drugs.

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“…The concentrations of haloperidol and ofloxacin in black hairs were different from those in white hairs (Uematsu et al, 1990(Uematsu et al, , 1992. Different concentrations of nicotine in black, brown and blond hairs were also reported (Gerstenberg et al, 1995).…”

Section: Distribution Of Ma and Ap In Hairmentioning

confidence: 82%

Analysis of methamphetamine and its metabolites in hair

Takayama

Iio

Tanaka

et al. 2003

Biomedical Chromatography

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Methamphetamine (MA) is a sympathomimetic amine whose abuse has become a serious problem in Japan, Korea, Taiwan and other Southeast Asian countries. The use of hair for the determination of MA use has become more commonplace. The maximum period in which MA and its main metabolites (amphetamine and p-hydroxymethamphetamine) can be detected in urine is about 10 days after its use. However, proof of MA use is possible in hair even several years after its use if the part of the hair that grew in the period of its use is available. In addition, segmental analysis of hair is capable of clarifying the history of MA abuse. This paper reviews the clean-up, extraction, analytical method and distribution of MA and its metabolites in hair from reports published in the last 20 years.

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Possible Effect of Pigment on the Pharmacokinetics of Ofloxacin and Its Excretion in Hair

Cited by 61 publications

References 12 publications

Relationship of Melanin Degradation Products to Actual Melanin Content: Application to Human Hair

Relationship of Melanin Degradation Products to Actual Melanin Content: Application to Human Hair

The measurement of a new antimicrobial quinolone in hair as an index of drug exposure.

Analysis of methamphetamine and its metabolites in hair

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