Possible deterioration of Apolipoproteins expression by HTLV-1 infection in favor of infected leukemic cells in adult T-cell leukemia/lymphoma (ATLL)

Javadifar, Amin; Ghezeldasht, Sanaz Ahmadi; Rahimi, Hossein; Valizadeh, Narges; Borojerdi, Zahra Rezaei; Vahidi, Zohreh; Rezaee, Seyed Abdolrahim

doi:10.1016/j.genrep.2022.101531

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Oncogenic Viruses and Host Lipid Metabolismdur1

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2023

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“…Javadifar et al . [174] found that the ATP-binding cassette sub-family A member 1 (ABCA1) expression levels in patients with ATLL were significantly higher than those in asymptomatic carriers, and that HAM/TSP and apolipoprotein E (ApoE) expression were higher in patients who were asymptomatic carriers than in patients with ATLL and HAM/TSP. This may be due to the need for leukaemia cells from patients with ATLL to synthesize more cholesterol to maintain cell membrane mobility.…”

Section: Oncogenic Viruses and Host Lipid Metabolismdurmentioning

confidence: 99%

Oncogenic viruses and host lipid metabolism: a new perspective

Gong

Zhang

Wen

et al. 2023

Journal of General Virology

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As noncellular organisms, viruses do not have their own metabolism and rely on the metabolism of host cells to provide energy and metabolic substances for their life cycles. Increasing evidence suggests that host cells infected with oncogenic viruses have dramatically altered metabolic requirements and that oncogenic viruses produce substances used for viral replication and virion production by altering host cell metabolism. We focused on the processes by which oncogenic viruses manipulate host lipid metabolism and the lipid metabolism disorders that occur in oncogenic virus-associated diseases. A deeper understanding of viral infections that cause changes in host lipid metabolism could help with the development of new antiviral agents as well as potential new therapeutic targets.

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Section: Oncogenic Viruses and Host Lipid Metabolismdurmentioning

confidence: 99%