Oncogenic viruses and host lipid metabolism: a new perspective

Abstract

As noncellular organisms, viruses do not have their own metabolism and rely on the metabolism of host cells to provide energy and metabolic substances for their life cycles. Increasing evidence suggests that host cells infected with oncogenic viruses have dramatically altered metabolic requirements and that oncogenic viruses produce substances used for viral replication and virion production by altering host cell metabolism. We focused on the processes by which oncogenic viruses manipulate host lipid metabolism and the lipid metabolism disorders that occur in oncogenic virus-associated diseases. A deeper understanding of viral infections that cause changes in host lipid metabolism could help with the development of new antiviral agents as well as potential new therapeutic targets.

Host mitochondria: more than an organelle in SARS-CoV-2 infection

“…Arginine (Arg) has been proposed to be a key amino acid for viral replication of many DNA and RNA viruses (Tome, 2021). Hijacking of host lipid metabolism by some viruses to improve viral replication has also been suggested (Gong et al, 2023).…”