2020
DOI: 10.1080/00016357.2020.1774076
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Possible association of periodontal disease with oral cancer and oral potentially malignant disorders: a systematic review

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Cited by 15 publications
(4 citation statements)
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“…Risulta difficile identificare questa condizione come fattore di rischio indipendente in quanto, spesso, pazienti con parodontite e numerose lesioni cariose sono anche pazienti fumatori e bevitori. Tuttavia la malattia parodontale potrebbe rappresentare un significativo fattore di rischio per il cancro orale anche in pazienti che non presentano gli altri fattori di rischio (31,32). È stata infatti osservata un'alterazione del microbioma orale dei pazienti con cancro orale con un aumento della presenza dei batteri parodontopatogeni (prevotella, fusobacterium, alloprevotella…), presenti in concentrazione aumentata fino a 3 volte rispetto ai controlli (33).…”
Section: Igiene Orale E Malattia Parodontaleunclassified
“…Risulta difficile identificare questa condizione come fattore di rischio indipendente in quanto, spesso, pazienti con parodontite e numerose lesioni cariose sono anche pazienti fumatori e bevitori. Tuttavia la malattia parodontale potrebbe rappresentare un significativo fattore di rischio per il cancro orale anche in pazienti che non presentano gli altri fattori di rischio (31,32). È stata infatti osservata un'alterazione del microbioma orale dei pazienti con cancro orale con un aumento della presenza dei batteri parodontopatogeni (prevotella, fusobacterium, alloprevotella…), presenti in concentrazione aumentata fino a 3 volte rispetto ai controlli (33).…”
Section: Igiene Orale E Malattia Parodontaleunclassified
“…In the same year, a meta‐analysis of 11 case‐control studies also indicated a two‐ to fourfold higher oral cancer risk among those with PD; however, authors reported high heterogeneity in included studies ( P <.05) 12 . A recent systematic review by Colonia‐García et al also reported an association between PD and oral malignancies, although concluded that available evidence is insufficient to draw solid conclusions due to differences in methods, case definition of PD and oral cancer location 13 …”
Section: Introductionmentioning
confidence: 99%
“…12 A recent systematic review by Colonia-García et al also reported an association between PD and oral malignancies, although concluded that available evidence is insufficient to draw solid conclusions due to differences in methods, case definition of PD and oral cancer location. 13 Early diagnosis of oral cancer is highly desirable as it can impact prognosis, healthcare costs and significantly increase 5-year survival rates from 40.1% (metastatic stage) to 85.1% (localized stage). 2 According to the 2010-2016 National Cancer Institute data, only 29% of oral cancers are diagnosed in the localized stage, 2 much lower than the Healthy People 2020 target goal of 35.9%.…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, chronic inflammatory processes were first linked to the development of cancer by Virchow in the 19th century. To date, 15–20% of human cancers are estimated to originate from an inflammatory process that promotes cell proliferation and malignant transformation [ 21 ]. Specifically, in animal models of periodontal biofilm-induced oral carcinogenesis, a higher incidence of epithelial dysplasia and oral carcinoma was found than in tobacco surrogate-induced carcinogenesis; a larger tumor size and a more marked reduction in the protective mechanisms of epithelial cell differentiation were also observed [ 6 ].…”
mentioning
confidence: 99%