Periodontitis and Cancer: Beyond the Boundaries of Oral Cavity

Amato, Alessandra

doi:10.3390/cancers15061736

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…Notably, significant differences in the oral flora of periodontitis patients have been observed between DKD patients and diabetics without DKD [26]. The influence of oral and periodontal microflora on systemic diseases extends beyond local inflammatory reactions, involving the dissemination of oral microbial virulence through the bloodstream, oropharynx, and respiratory tract [27]. This increasing prevalence of DKD necessitates deeper investigation into its association with periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Deciphering the molecular nexus of BTG2 in periodontitis and diabetic kidney disease

Pan,

Teng,

Wang

et al. 2024

BMC Med Genomics

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Objective To investigate the role of BTG2 in periodontitis and diabetic kidney disease (DKD) and its potential underlying mechanism. Methods Gene expression data for periodontitis and DKD were acquired from the Gene Expression Omnibus (GEO) database. Differential expression analysis identified co-expressed genes between these conditions. The Nephroseq V5 online nephropathy database validated the role of these genes in DKD. Pearson correlation analysis identified genes associated with our target gene. We employed Gene Set Enrichment Analysis (GSEA) and Protein-Protein Interaction (PPI) networks to elucidate potential mechanisms. Expression levels of BTG2 mRNA were examined using quantitative polymerase Chain Reaction (qPCR) and immunofluorescence assays. Western blotting quantified proteins involved in epithelial-to-mesenchymal transition (EMT), apoptosis, mTORC1 signaling, and autophagy. Additionally, wound healing and flow cytometric apoptosis assays evaluated podocyte migration and apoptosis, respectively. Results Analysis of GEO database data revealed BTG2 as a commonly differentially expressed gene in both DKD and periodontitis. BTG2 expression was reduced in DKD compared to normal conditions and correlated with proteinuria. GSEA indicated enrichment of BTG2 in the EMT and mTORC1 signaling pathways. The PPI network highlighted BTG2’s relevance to S100A9, S100A12, and FPR1. Immunofluorescence assays demonstrated significantly lower BTG2 expression in podocytes under high glucose (HG) conditions. Reduced BTG2 expression in HG-treated podocytes led to increased levels of EMT markers (α-SMA, vimentin) and the apoptotic protein Bim, alongside a decrease in nephrin. Lower BTG2 levels were associated with increased podocyte mobility and apoptosis, as well as elevated RPS6KB1 and mTOR levels, but reduced autophagy marker LC3. Conclusion Our findings suggest that BTG2 is a crucial intermediary gene linking DKD and periodontitis. Modulating autophagy via inhibition of the mTORC1 signaling pathway, and consequently suppressing EMT, may be pivotal in the interplay between periodontitis and DKD.

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Section: Discussionmentioning

confidence: 99%

Deciphering the molecular nexus of BTG2 in periodontitis and diabetic kidney disease

Pan,

Teng,

Wang

et al. 2024

BMC Med Genomics

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“…The plaque index (PI) is a commonly used clinical index to assess oral hygiene status based on the accumulation of gingival biofilm around the teeth, gingiva, and gingival sulcus or periodontal pockets [43]. Gingival biofilm is a polymicrobial biofilm composed of diverse bacterial complexes that mutually benefit from coaggregation, adhesion, and metabolic interactions [44,45] and is the primary etiologic factor in the development, progression, and recurrences of periodontal inflammation [46][47][48]. The main biofilm-induced periodontal diseases are gingivitis, a non-destructive inflammation of the gingiva that is reversible by controlling the biofilm, and periodontitis, which instead leads to the irreversible loss of attachment, periodontal ligament, and alveolar bone [49][50][51] and is also dependent on the individual's susceptibility and responsiveness to the inflammatory insult [52][53][54].…”

Section: Impact Of Clear Aligners Versus Fixed Appliances On Periodon...mentioning

confidence: 99%

Impact of Clear Aligners versus Fixed Appliances on Periodontal Status of Patients Undergoing Orthodontic Treatment: A Systematic Review of Systematic Reviews

et al. 2023

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The present umbrella review of four systematic reviews with meta-analysis aimed to assess whether clear aligners are associated with better periodontal conditions compared with fixed appliances in patients undergoing orthodontic treatment. The present study protocol was developed in accordance with the PRISMA statement before the literature search, data extraction, and analysis and was registered on PROSPERO (CRD42023401808). The question formulation, search, and study selection strategies were developed according to the PICO model. Systematic reviews with a meta-analysis published in English without date restriction were electronically searched across the Cochrane Library, Web of Science (Core Collection), Scopus, EMBASE, and MEDLINE/PubMed databases until 10 February 2023. An assessment of study quality was performed using the AMSTAR 2 tool. Differences in the PI, GI, and BOP in the short- and medium-term follow-ups, in the PPD in long-term follow-up, and the gingival recessions in the short-term follow-up were found between subjects with clear aligners and fixed appliances, revealing a slight tendency for clear aligners to be associated with healthier periodontal conditions. However, even if statistically significant, such differences would be negligible in a clinical environment. Therefore, the impact of orthodontic treatment with clear aligners and fixed appliances on periodontal health status should be considered comparable.

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“…In the United States, HPV vaccine administration is currently recommended for girls aged 11-12 years, which was extended to 26 years in 2019, according to the Advisory Committee on Immunization Practices (ACIP), and for boys up to 21 years [68]. Nevertheless, HPV vaccination may also benefit individuals at high risk for new viral infection between the ages of 27 and 45 [6,27,69]. However, according to the American Cancer Society (ACS), HPV vaccines should be administered between the ages of 9 and 12 years for optimal efficacy [18], as administration at an older age seems less effective for cancer prevention [18,20,70].…”

Section: Youtube Videos On Hpv Infection Oral Lesions and Vaccination...mentioning

confidence: 99%

HPV-Related Oral Lesions: YouTube Videos Suitability for Preventive Interventions including Mass-Reach Health Communication and Promotion of HPV Vaccination

Spirito

Amato

D'Ambrosio

et al. 2023

IJERPH

Self Cite

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Given the need to improve patient knowledge about HPV-related oral lesions, awareness of HPV infection prevention measures, and compliance with vaccination, as well as patient demand for free and easy access to well-tailored and time-saving health information, the present cross-sectional study examined the accuracy of relevant YouTube videos and their suitability for mass-reach health communication and HPV vaccination promotion. A video search was performed, using keywords obtained from the Google Trends website, until 9 January 2023. Video selection and data collection were performed by independent, pre-calibrated examiners. Descriptive statistics were performed on videos’ general characteristics, source reliability, popularity, information and quality, content topics, vaccination-encouraging/discouraging messages, and educational value. Pearson’s correlation was calculated between educational value and all parameters. Mann–Whitney U test compared very low/low vs. medium/good/excellent educational value and HPV vaccination-encouraging vs. -discouraging videos. Most of the 97 YouTube videos analyzed were moderately accurate and reliable, 53% had moderate/good/excellent educational value, and 80% encouraged HPV vaccination, making them suitable for mass-reach communication. The limited role of oral healthcare providers in uploading relevant content, with the poor dissemination of information about HPV-related benign and malignant oral lesions, may be expanded by purposefully using YouTube and other mass media to improve patient knowledge of HPV-related oral lesions and promote HPV vaccination, which also underscores its potential beneficial oral effects.

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Periodontitis and Cancer: Beyond the Boundaries of Oral Cavity

Abstract: Oral squamous cell carcinoma (OSCC) is the 16th most common cancer and the 15th leading cause of death worldwide, with an incidence of 4 cases per 100,000 people [...]

Cited by 7 publications

References 33 publications

Deciphering the molecular nexus of BTG2 in periodontitis and diabetic kidney disease

Deciphering the molecular nexus of BTG2 in periodontitis and diabetic kidney disease

Impact of Clear Aligners versus Fixed Appliances on Periodontal Status of Patients Undergoing Orthodontic Treatment: A Systematic Review of Systematic Reviews

HPV-Related Oral Lesions: YouTube Videos Suitability for Preventive Interventions including Mass-Reach Health Communication and Promotion of HPV Vaccination

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