Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents

Abstract

Accumulating evidence suggests an association between the SIRT1 gene and human psychiatric disorders. The aim of the study was to investigate the association between SIRT1 and predisposition to antisocial personality traits (ASP) in Chinese adolescents. Participants consisted of 327 controls and 261 juvenile offenders who were diagnosed with predisposition to ASP according to the Personality Diagnostic Questionnaire. Four tag single nucleotide polymorphisms (tagSNPs) of SIRT1, namely rs12778366, rs7896005, rs10823112, and rs4746720, were genotyped. Association analysis between individual SNPs and ASP risk revealed the CC genotype of rs4746720 to be significantly associated with reduced risk of ASP (OR = 0.51, 95% CI = 0.33–0.77, adjusted P = 0.007). Haplotype analysis showed the TAAC haplotype was associated with reduced susceptibility to ASP (OR = 0.72, 95% CI = 0.57–0.91, P = 0.005). Moreover, rs4746720 variants were found to not only have a direct impact on ASP susceptibility but also modulate the effect of alcohol consumption (Y = 0.022X + 0.431 vs. Y = −0.066X + 0.387). The present study is the first to report a significant association between SIRT1 polymorphisms and ASP in adolescents. This finding is expected to aid in the development of effective interventions for this socially and personally costly disorder.

SIRT1 accelerates the progression of activity-based anorexia

“…The consequences of SIRT1 activation that we describe here, and those established by others [7][8][9]11,12,14,16,48,67,68 , overlap closely with physiological changes associated with AN pathologies, which supports our hypothesis of AN development (Fig. 4g).…”

Biological Clocks and Rhythms of Anger and Aggression

“…More recent evidence has implicated the role of the nicotinamide adenine dinucleotide-dependent sirtuin proteins (SIRT)—specifically SIRT1—in both the regulation of the genetic circadian clock and the risk for diagnosis of antisocial personality disorder in humans (Chang et al, 2017 ). SIRT1 regulates the expression of bmal1 and per2 through deacetylation (Asher et al, 2008 ; Nakahata et al, 2008 ), and overexpression of sirt1 in rodents leads to elevated levels of bmal1 and per2 , and shortens the period of the circadian clocks in the brain controlling locomotor activity (Chang and Guarente, 2013 ).…”

Are Owls and Larks Different When it Comes to Aggression? Genetics, Neurobiology, and Behavior

“…This variant was also associated with eveningness when concomitant with the minor allele of Clock 1131T>C (TC or CC) single nucleotide polymorphism (SNP; Garaulet et al, 2012). In a Chinese population of male juveniles, Sirt1 polymorphisms were associated with a predisposition for ASPD (Chang et al, 2017). Chang et al (2017) suggest that altered SIRT1 expression disrupts circadian rhythms and that disruption contributes to the pathogenesis of ASPD.…”

“…Chang et al (2017) suggest that altered SIRT1 expression disrupts circadian rhythms and that disruption contributes to the pathogenesis of ASPD. The finding that Sirt1 polymorphisms have also been associated with a late chronotype type bolsters the argument (Garaulet et al, 2012;Chang et al, 2017).…”