“…33, 41, 42], IDDM seems to alter TSH and PRL secre tion simultaneously in euthyroid subjects; modifications of these hormones have been studied as an associated phenomenon and an altered dopaminergic control of pituitary function has been proposed as the likely cause of their disorder [18]. TSH and PRL responses to metoclopramide, an antidopaminergic agent, have been tested to prove this hypothesis [ 18], However, because of its interactions with other ncurotransmitters such as serotonin [20,21,26,34] or acetyl choline [3,12,19,25,26,43], mctoclopramide does not seem to be just an antagonist of dopamine. Furthermore, data in the litera ture describing TSH and PRL alterations in IDDM are scant and often contradictory, since decreased [9,18], increased [1,22] or unchanged [6,10,13,15,24,30,32,33,38,40,42] circulating levels of these hormones have been reported.…”