Possibilities of using branched-chain amino acids for the treatment and prevention of sarcopenia in elderly and old patients (literature review)

Kurmaev, D P; Bulgakova, S.; Treneva, E V; Chetverikova, I S; Kosareva, O.G.; Шаронова, Л. А.; Dolgikh, Yu.A. Dolgikh

doi:10.29413/abs.2023-8.3.11

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Помимо очевидной роли в построении молекул белков, аминокислоты c разветвлёнными боковыми цепями имеют множество других функций. Считается, что при мышечной работе они могут использоваться для синтеза промежуточных соединений цикла трикарбоновых кислот и глюконеогенеза, то есть выступают в качестве источников энергии [48].…”

Section: возможные стратегии профилактики и леченияunclassified

Insulin resistance, type 2 diabetes mellitus and sarcopenia

Kurmaev,

Bulgakova,

Treneva

2024

ECG

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Sarcopenia is a chronic age-associated disease, the prevalence of which increases with aging. The primary form is associated with aging, when no other causes have been identified, the cause of secondary sarcopenia may be various diseases, including type 2 diabetes mellitus (DM2). One of the common links in the pathogenesis of DM2 and sarcopenia is insulin resistance. A combination of sarcopenia and obesity is often observed. The interrelation of these pathological processes, etiology and pathogenesis are presented in this literature review.

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Section: возможные стратегии профилактики и леченияunclassified

Insulin resistance, type 2 diabetes mellitus and sarcopenia

Kurmaev,

Bulgakova,

Treneva

2024

ECG

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Clinical calculator for calculating appendicular musculoskeletal mass of elderly patients according to anthropometry and bioimpedance analysis

Pervyshin,

Bulgakova,

Kurmaev

et al. 2023

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Objective: development of an applied clinical calculator for calculating the appendicular mass of skeletal muscles (ASMM Calculator) in elderly patients based on bioimpedance analysis of body composition and anthropometry.Material and methods: the algorithm of the ASMM Calculator was developed based on the analysis of the results of a single-stage crosssectional study of G. Sergi (Department of Geriatrics, University of Padua, Italy); the calculation of appendicular musculoskeletal mass and its index is based on the values of anthropometry and bioimpedance analysis of body composition.Results:the matrix of the ASMM Calculator allows you to determine objective quantitative criteria for sarcopenia (appendicular musculoskeletal mass and its index) based on the values of five independent variables: the patient’s gender; height and body weight, electrical and reactive esistance of the body, the program provides for use directly in outpatient admission, has a volume of 12 kB, does not require specific hardware and software means, can be installed on a mobile device.Conclusions: the use of the ASMM calculator in clinical practice allows the doctor to establish diagnostic criteria for sarcopenia in a timely manner, does not require significant professional time, provides grounds for verifying the diagnosis in accordance with the principles of evidence-based medicine; the program can be integrated into various medical information systems as a module of the medical decision support system.

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Production Technology Optimization for the Functional Milk Drink Enriched with the Essential Nutrient Zinc

Kostenko,

Blinov,

Poydun

et al. 2024

Food Industry

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Whey is a secondary dairy raw material and contains easily digestible proteins, vitamins, minerals. It has a rich nutrient composition and can serve as the basis for functional drinks. In this work, a man optimized the production technology for functional milk drink based on molasses and whey enriched with the essential trace element zinc. The first stage consists of the quantum chemical modeling of the chelate complex of L-leucine, nicotinic acid and the essential trace element zinc. As a result, this interaction is energetically advantageous (∆E = 1774.380 kcal/mol) and chemically stable (η = 0.031 eV). At the next stage, the researchers studied the technological parameters impact on the complex stability. As a result, the optical density is in the optimal range from 2.45 to 2.84 rel. units for all values of the varied parameters. A man generated functional milk drink samples consisting of whey powder, molasses and the developed complex, subjected to the ultrasonic treatment subsequently. The authors scrutinize physicochemical properties of the obtained samples, determining, as a result, the positive impact of ultrasonic treatment on the sample properties. At the last stage, a man run an organoleptic evaluation of dairy drinks. The complex introduction into the functional milk drink composition and treating it with ultrasonic with maximum amplitude is the optimal solution for the of this drink implementation to dairy enterprises. Thus, the milk and dairy products enrichment with an additive based on a chelated complex of the trace element zinc is a very appropriate and promising solution.

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Possibilities of using branched-chain amino acids for the treatment and prevention of sarcopenia in elderly and old patients (literature review)

Cited by 3 publications

References 52 publications

Insulin resistance, type 2 diabetes mellitus and sarcopenia

Insulin resistance, type 2 diabetes mellitus and sarcopenia

Clinical calculator for calculating appendicular musculoskeletal mass of elderly patients according to anthropometry and bioimpedance analysis

Production Technology Optimization for the Functional Milk Drink Enriched with the Essential Nutrient Zinc

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