Possibilities of modern echocardiographic technologies in the early diagnosis of the cardiotoxic effect of chemotherapy drugs anthracycline series in cancer patients

Nedogoda, S V; Конради, А.; Звартау, Н. Э.; Чумачек, Е. В.; Ledyaeva, A. A.; Tsoma, V. V.; Salasyuk, A. S.; Judina, J S; Смирнова, В. О.; Khripaeva, V J; Палашкин, Р. В.

doi:10.18087/cardio.2417

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…ОРИГИНАЛЬНЫЕ СТАТЬИ § В связи с достигнутыми успехами в лечении рака молочной железы, с увеличением периода ремиссии и продолжительности жизни больных в настоящее время все больше внимания уделяется проблеме кардиотоксичности, развивающейся на фоне проведения противоопухолевой терапии [1][2][3][4][5]. Одним из наиболее серьезных осложнений химиотерапии является формирование систолической и диастолической дисфункции миокарда, развитие и быстрое прогрессирование ХСН [6,7]. Несмотря на то, что кардиотоксичность как следствие химиолучевой терапии изучена достаточно хорошо, до настоящего времени нет достаточной доказательной базы, отсутствуют общепринятые рекомендации и стандарты лечения этого осложнения у больных раком молочной железы.…”

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Age characteristics of risk cardiovascular complications in women with left breast cancer with preserved ejection fraction at the stage of chemotherapy and radiotherapy

Вологдина

Жабина

2019

Kardiologiia

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Aim. A study of the risk factors for middle-aged and elderly women HER2neu with negative left breast cancer and a normal ejection fraction at the stage of chemoradiotherapy in everyday clinical practice. Matherial and methods. 61 women with left breast cancer without severe cardiovascular pathology were examined at the stage of doxorubicin therapy and 3D conformal radiation therapy. Group 1 comprised 32 patients of middle age (49.8 ± 4.5 years). Group 2 comprised 29 elderly patients (68.3 ± 3.6 years). In addition to Score risk assessment, additional factors, including psychosocial factors, were studied. All patients underwent ECG, echocardiography and 24-hour ECG monitoring. Anxiety levels were assessed using the HADS scale and scale CH. D. Spielberger –Yu.L. Khanin. The study was conducted before the start of treatment, after the completion of the doxorubicin course and after the completion of the course of radiotherapy. Results with discussion. In middle-aged patients, moderate Score risk was found in 21.9%, in the elderly at 58.6% (p = 0.0043, RR 2.68, 95% CI 1.301–5.520). A high Score risk was found in 15.6% of middle-aged patients and 41.4% of elderly patients (p = 0.0438, RR 2.648, 95% CI 1061–6.607). The most common risk factors in the patients studied in addition to age were heredity, overweight, hypercholesterolemia and diabetes mellitus. All examined patients had moderate reactive anxiety. Patients of middle age have moderate personal anxiety, in elderly patients high personal anxiety. After treatment with doxorubicin in a cumulative dose not exceeding 360 mg/m2 , a reduction in the ejection fraction below 50% was found in 6 middle-aged patients and 17.2% in elderly patients. Asymptomatic diastolic dysfunction was detected in 31.3% of middle-aged patients and 55.2% of the elderly. In patients of both groups, after arranging treatment, arrhythmia was detected. Conclusions. The obtained data indicate to the need for in-depth examination of middle-aged and especially elderly patients with left breast cancer with an assessment of risk factors and conducting an in-depth examination using Echocardiography, 24-hour ECG monitoring and psychological testing to prevent and early detection of cardiovascular complications.

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Age characteristics of risk cardiovascular complications in women with left breast cancer with preserved ejection fraction at the stage of chemotherapy and radiotherapy

Вологдина

Жабина

2019

Kardiologiia

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Strategies of early diagnosis and management of chemotherapy cardiotoxicity in elderly patients

Oynotkinova¹,

Matskeplishvili²,

Potievskaya³

et al. 2022

Profil. med.

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Immune checkpoint inhibitors related cardiovascular toxicity: 3‑mounth follow-up

et al. 2023

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Aim. To analyze the condition of the cardiovascular system in oncological patients receiving immune antitumor therapy with immune checkpoint inhibitors (CPIs) based on results of laboratory and instrumental examinations during a 3-month follow-up.Material and methods. This multicenter prospective observational study included 49 patients (25 men and 24 women aged 65.6±8.7 and 64.3±9.6 years, respectively). A laboratory screening (C-reactive proteins, troponin I, N-terminal pro-brain natriuretic peptide), EchoCG, and carotid ultrasound were performed for all patients. 27 patients were followed up at 3 months after the antitumor therapy initiation. Statistical analysis was performed with the StatPlus 8.0.3 software.Results. Incidence of cardiovascular complications was 16.3 %. The following significant changes in EchoCG parameters were observed: LV EF; (p=0.017), increased LV end-systolic volume (ESV) (р=0.023), and increased LV index of myocardial performance (LIMP; р=0.016). The degree of changes in ESV (ΔESV) depended on a history of chronic heart failure (р=0.03), whereas the degree of changes in EF (ΔEF) depended on the patient’s age at the initiation of antitumor therapy (р=0.006). Ultrasound showed an increase in maximum carotid stenosis (р=0.018).Conclusion. The study showed a high incidence of newly developed cardiovascular complications associated with the CPI treatment as well as the presence of changes in EchoCG parameters and data of carotid ultrasound.

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Possibilities of modern echocardiographic technologies in the early diagnosis of the cardiotoxic effect of chemotherapy drugs anthracycline series in cancer patients

Cited by 5 publications

References 37 publications

Age characteristics of risk cardiovascular complications in women with left breast cancer with preserved ejection fraction at the stage of chemotherapy and radiotherapy

Age characteristics of risk cardiovascular complications in women with left breast cancer with preserved ejection fraction at the stage of chemotherapy and radiotherapy

Strategies of early diagnosis and management of chemotherapy cardiotoxicity in elderly patients

Immune checkpoint inhibitors related cardiovascular toxicity: 3‑mounth follow-up

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