Posner-Schlossman syndrome in Wenzhou, China: a retrospective review study

Abstract

Our results suggest a relatively high incidence of PSS in Wenzhou, a southeastern city in China. Young, male adults are prone to be affected in spring. However, the aetiology and other risk factors are still waited to be clarified.

CFH I62V as a Putative Genetic Marker for Posner-Schlossman Syndrome

“…Fifty-six PSS patients were recruited for this study. The diagnosis of PSS was based on the following clinical features: repeated episodes of unilateral moderate to high elevation of IOP with blurred vision, mild anterior chamber inflammation and mutton-fat-like keratic precipitates (KPs), open anterior chamber angles under high IOP, and no obvious posterior synechiae of the iris (20). For each patient, the clinical course of ocular inflammation was documented, including visual acuity, slit-lamp biomicroscopy, IOP, age at onset, clinical features (KPs, posterior synechiae, and anterior chamber cells), laterality, frequency of recurrence, and complications of PSS.…”

The genetic contribution of HLA-E*01:03 and HLA-E*01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese

“…Between December 2015 and December 2018, a total of 97 unrelated PSS patients were recruited from patients attending the Shenzhen Eye Hospital Clinic. The diagnosis of PSS was based on the following criteria (1)(2)(3)(4)12,13): (I) single-eye onset in young adults, mild discomfort in the eye, and no significant decrease or slight decrease in visual acuity; (II) elevated IOP with recurrent episodes and mutton-fat KPs; (III) open iridocorneal angle under high IOP without peripheral anterior synechia; (IV) no visual field loss and optic nerve damage in patients with shorter course of disease; and (V) no history of other eye diseases except for refractive error. Ninety unrelated subjects were recruited at the Shenzhen Blood Center from healthy volunteer blood donors with normal IOP and optic discs.…”

“…PSS is a secondary glaucoma, which occurs in young adults. PSS is a self-limiting and recurrent eye disorder, and 24.3% of patients have more than 2 episodes per year, up to 12 episodes in some cases (2). The main clinical manifestations of PSS are the elevated intraocular pressure (IOP) in one eye with keratic precipitates (KPs).…”

Metabolomic Profile of Posner–Schlossman Syndrome: A Gas Chromatography Time-of-Flight Mass Spectrometry-Based Approach Using Aqueous Humor

“…Posner–Schlossman syndrome (PSS), also called glaucomatocyclitic crisis (GCC), is a disease with clinically recurrent unilateral anterior uveitis with markedly elevated intraocular pressure (IOP) and subsequent progression to optic neuropathy (Eissler, 1948; Moorthy et al, 1997). Retrospective studies have reported increased annual incidence of PSS, especially in China (Jiang et al, 2017). The clinical management of PSS is still challenging.…”

“…Long-term administration of ganciclovir may control the symptoms of certain types of PSS (Miyanaga et al, 2010; Sobolewska et al, 2014; Su et al, 2014). However, the patients still experience progressive endothelium loss and a high relapse rate after the withdrawal of the drug (Moorthy et al, 1997; Chee and Jap, 2010; Miyanaga et al, 2010; Sobolewska et al, 2014; Su et al, 2014; Jiang et al, 2017). Eventually, repeated uncontrolled elevation of IOP can result in irreversible optic neuropathy and vision loss.…”