Positron Emission Tomography of the Reward System

Romero-Miguel, Diego; Lamanna-Rama, Nicolás; Casquero-Veiga, Marta; Gómez‐Rangel, Vanessa; Desco, Manuel

doi:10.1007/978-1-0716-1146-3_14

Cited by 2 publications

(3 citation statements)

References 199 publications

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Section: Discussionmentioning

confidence: 92%

“…Other animal models of memory impairments have shown that therapy with minocycline improves recognition memory (40). Similarly, previous studies elaborated on minocycline's anti-amyloid and antiinflammatory roles in various neurodegenerative diseases (40)(41). The inhibitory effects of minocycline on amyloidogenic and inflammatory pathways explained its beneficial role to act as neuroprotection, preserve the neuronal structure and improve memory deficits-induced AD (41).…”

Section: Discussionmentioning

confidence: 92%

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Minocycline Protects Against LPS-induced Neuronal Death and Memory Impairment in the Rat

Qaid¹,

Abdullah²,

Zakaria³

et al. 2022

MJMHS

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Introduction: Minocycline has been demonstrated to have potent effects on neurologic structures and functions in several animal models. However, its neuroprotective properties following a single injection of lipopolysaccharide (LPS) in an adult rat model have not been clearly elucidated. This study investigated minocycline’s neuroprotective effects in the LPS-induced neuroinflammation rat model. Methods: Fifty adult male Sprague Dawley rats were split into five groups at random: (i) control, (ii) distilled water-treated LPS, (iii) 25 mg/kg minocycline-treated LPS, (iv) 50 mg/kg minocycline-treated LPS, and (v) 10 mg/kg memantine-treated LPS. On day 5, LPS (5 mg/kg) was given intraperitoneally once, whereas minocycline and memantine were given once daily for 14 days. Results: LPS was found to significantly induce β-amyloid peptide deposition and neuronal damage, and impair recognition memory, while administration of minocycline dose-dependently reversed these effects. These data suggest that LPS-induced recognition memory impairment by inducing β-amyloid peptide deposition and neuronal damage in the cortical and hippocampal areas. Furthermore, we compared minocycline with memantine administration, and these data suggested better effects in minocycline (50 mg/kg) and comparable effects between minocycline (25 mg/kg) and memantine (10 mg/kg) treatments in reducing β-amyloid peptide deposition, neuronal damage and recognition memory impairment induced by LPS. Conclusion: Minocycline may be a strong contender as an effective preventive-therapeutic drug for neuroinflammatory diseases such as Alzheimer’s disease (AD) based on these findings.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 92%

Minocycline Protects Against LPS-induced Neuronal Death and Memory Impairment in the Rat

Qaid¹,

Abdullah²,

Zakaria³

et al. 2022

MJMHS

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“…It is mainly due to the different doses of the drug used in both types of studies, difficulty in selecting patients at the same stage of the disease. Furthermore, some of the symptoms of these diseases are impossible to reproduce in an animal model [39].…”

Section: Anti-apoptic Effectmentioning

confidence: 99%

Tetracyclines - An Important Therapeutic Tool for Dermatologist

Orylska-Ratyńska¹,

Placek²,

Owczarczyk‐Saczonek³

2022

Preprint

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Tetracyclines are a group of antibiotics whose first representative was discovered over 70 years ago. Since then, they have been of great interest in dermatology. In addition to their antibacterial activity, they are able to inhibit metalloproteinases and exhibit anti-inflammatory, anti-apoptotic and antioxidant effects. The side effects have been thoroughly studied over the years. The most characteristic and important in daily dermatolgical practice are: phototoxicity, hyperpigmentation, onycholysis, photoonycholysis, induced lupus erythematosus, idiopathic intracranial hypertension. In this article, we summarize the use of tetracyclines in infectious diseases and inflammatory dermatoses, and further discuss indications where the efficacy and safety of tetracyclines have been highlighted over the past few years.

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Positron Emission Tomography of the Reward System

Cited by 2 publications

References 199 publications

Minocycline Protects Against LPS-induced Neuronal Death and Memory Impairment in the Rat

Minocycline Protects Against LPS-induced Neuronal Death and Memory Impairment in the Rat

Tetracyclines - An Important Therapeutic Tool for Dermatologist

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