Positron emission tomography for the detection of colorectal adenomas

Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography and computed tomography (FDG-PET/CT)

“…We demonstrated that the sensitivity of PET/CT for detecting colorectal lesions larger than 10 mm was approximately 85%, which was similar to the results shown in previous studies [13,23]. Although the size-and pathology-dependence (higher in high-grade and villous component, and malignancy) of PET/CT sensitivity had also been observed in previous reports [9,12,13], our large-scale study provided sufficient data for confirming the efficacy of PET/CT for detecting clinically relevant colorectal lesions. In contrast to previous reports, we calculated the specificity, PPV, NPV, and accuracy by dividing the total colon into six segments.…”

“…However, these studies had problems in precisely evaluating the ability of PET. Principally, these studies were small-scale and/or used a biased cohort [10,12,13], and not all patients underwent both PET and colonoscopy [11,[14][15][16][17]. In addition, no largescale studies have been conducted using PET/CT for detecting colorectal lesions according to morphology, pathology, and location.…”

Sensitivity of 2-[18F]fluoro-2-deoxyglucose positron emission tomography for advanced colorectal neoplasms: a large-scale analysis of 7505 asymptomatic screening individuals

“…FDG-PET is a noninvasive functional imaging modality that reflects the change in glucose metabolism in tumor cells, and has been applied in oncology [12]. With regard to colorectal tumors, previous studies have shown that FDG-PET can detect not only CRC but also colorectal adenomas, and the sensitivity of FDG-PET for colorectal tumors has been examined in several studies [13][14][15][16][17][18][19][20][21][22][23][24]. However, most members of the study population were not asymptomatic screening individuals.…”

Diagnostic accuracy of 18F-FDG PET/CT for detection of advanced colorectal adenoma

“…12 The present data once again challenge the concept that size is the only variable explaining adenoma detection. In another well-performed, large study, Ravizza et al 22 found by multiand univariate analyses that a villous component and highgrade dysplasia were independently associated with PET positivity. Nonetheless, advanced histology is not Table 3 Measures unequivocally more metabolically active 21 or detectable.…”

“…1,6,7,14,17 However, the present authors and others have shown the ability of PET to detect smaller adenomas, possibly due to more advanced histology (e.g., villous component or highgrade dysplasia) possibly due to greater metabolic activity. 9,12,14,22 Others report incidental detection of adenomas as small as 3e5 mm with high-grade dysplasia. 12 The present data once again challenge the concept that size is the only variable explaining adenoma detection.…”