Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography and computed tomography (FDG-PET/CT)

Hirakawa, Tomoko; Kato, Jun; Okumura, Yoshihiro; Takahashi, Sakuma; Suzuki, Hideyuki; Akita, Mitsuhiro; Higashi, Reiji; Saito, Shunsuke; Kaji, Eisuke; Uraoka, Toshio; Hiraoka, Sakiko; Yamamoto, Kazuhide

doi:10.1007/s00535-011-0473-z

Cited by 10 publications

(5 citation statements)

References 30 publications

(36 reference statements)

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“…These results are in accordance with those of two previous studies showing that the detection rates of FDG PET/CT are positively correlated with the size of advanced colorectal neoplasms and the degree of dysplasia [18], [19]. In general, the detection rates of FDG PET/CT imaging in the screening of colorectal lesions depend on size of lesions [18]–[20]. In the present study, we found that 30 of the 32 lesions missed on FDG PET/CT scans had a longest axis ≤1.5 cm according to the colonoscopy results.…”

Section: Discussionsupporting

confidence: 93%

“…In this study, we found that an endoscopic size ≤1.5 cm and the presence of low-grade dysplasia were unfavorably associated with the likelihood of having positive FDG-PET/CT findings. These results are in accordance with those of two previous studies showing that the detection rates of FDG PET/CT are positively correlated with the size of advanced colorectal neoplasms and the degree of dysplasia [18], [19]. In general, the detection rates of FDG PET/CT imaging in the screening of colorectal lesions depend on size of lesions [18]–[20].…”

Section: Discussionsupporting

confidence: 92%

“…These prevalence figures are in accordance with those previously reported in the literature [25]. Differently from previous studies which were focused on high-risk groups with advanced neoplasms or CRCs [18]–[20], we specifically investigated a general population sample. The inclusion of average-risk subjects may thus explain the lower detection rate of advanced neoplasms on FDG PET/CT scans observed in this report.…”

Section: Discussionsupporting

confidence: 83%

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A Comparison of Positron Emission Tomography and Colonoscopy for the Detection of Advanced Colorectal Neoplasms in Subjects Undergoing a Health Check-Up

et al. 2013

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Background & AimsThere is no agreement as to whether F-18 fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET/CT) screening for advanced colorectal neoplasms is meaningful. This retrospective study was undertaken to determine whether FDG PET/CT may be a valuable screening tool for the detection of advanced colorectal neoplasms.MethodsA retrospective review of the records of 1,109 FDG PET/CT scans acquired from January 2007 to December 2011 was performed. Colonoscopy and FDG PET/CT imaging were performed within two days of each other. The results of colonoscopy were taken as the gold standard, either with or without the results of the histopathological examination. An advanced neoplasm was defined as the presence of a malignant tumor, an adenoma ≥1 cm, or histological evidence of high-grade dysplasia or significant villous components.ResultsA total of 36 subjects had advanced colorectal neoplasms detected by colonoscopy (totaling 38 neoplasms). Six of the 38 neoplasms were also detected by FDG PET/CT. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of FDG PET/CT in the detection of advanced colorectal neoplasms were 15.8% (6/38), 99.1% (1063/1073), 37.5% (6/16), 97.1% (1063/1095), and 96.2% (1069/1111) respectively. The presence of lesions with an endoscopic size ≤1.5 cm (P<0.001) and low-grade dysplasia (P<0.001) were the main predictors of false-negative FDG PET/CT findings.ConclusionsWe conclude that FDG PET/CT screening of advanced colorectal neoplasms is unwarranted, especially in the presence of lesions with an endoscopic size ≤1.5 cm or low-grade dysplasia.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 83%

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A Comparison of Positron Emission Tomography and Colonoscopy for the Detection of Advanced Colorectal Neoplasms in Subjects Undergoing a Health Check-Up

et al. 2013

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“…By contrast, esophagogastroscopy could detect cases of cancer that were overlooked by PET/CT [46]. Furthermore, small-sized colorectal lesions were significantly missed by PET/CT based on 492 patients who underwent both PET/CT and CS [48]. Further, the physiological uptake on the intestine masks colorectal lesions [49].…”

Section: Discussionmentioning

confidence: 99%

Quadruple Multiple Primary Malignancies: Early Detection of Second Primary Malignancy by Esophagogastroduodenoscopy/Colonoscopy Is Crucial for Patients with Classic Kaposi’s Sarcoma

et al. 2020

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Currently, Kaposi’s sarcoma (KS) is treated following the recommendations of international guidelines. These guidelines recommend esophagogastroduodenoscopy/colonoscopy for detecting multicentric KS of visceral lesions. Second primary malignancies (SPMs) are also a common KS complication; however, information on their detection and treatment is unfortunately not yet indicated in these guidelines. This paper reports on an 86-year-old man who suffered from quadruple primary malignancies: skin classic KS with colon adenocarcinoma, oral squamous cell carcinoma (maxilla), and well-differentiated stomach adenocarcinoma. Gastric cancer was incidentally detected during esophagogastroduodenoscopy, which was performed to detect visceral KS. We suggest that esophagogastroduodenoscopy/colonoscopy be routinely performed during the follow-up of patients with KS. As SPMs are crucial complications in patients with KS, these malignancies should be detected as early as possible.

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“…Recent noninvasive diagnosing modalities, such as positron emission tomography or diffusionweighted imaging MRI, have a good sensitivity, but their space resolution is limited in tumors of small size. 5,6 Therefore, these modalities are still diagnostic assistance, and the ''gold standard'' of differential diagnosis of pulmonary mass is still a histopathological examination. Formerly, obtaining tissues by open thoracotomy was very invasive, and therefore an exploratory resection or biopsy of the pulmonary lesions that are strongly suspicious for the metastasis of pancreatic cancer has not been agreeably accepted in a balance of its diagnostic merit and surgical risk.…”

Section: Discussionmentioning

confidence: 99%

Appraisal of Aggressive Excisional Biopsy for a Possible Isolated Lung Metastasis of Pancreatic Cancer: Repeated Extirpation Contributes to Long Survival

Takahashi

Yoshioka

Uchinami

et al. 2016

International Surgery

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Although rare, there is a group of patients in whom lung metastases of pancreatic cancer develop isolatedly. We here report two cases of isolated lung metastasis of pancreatic cancer who gained long survival by repeated surgical resections of the nodules. Case 1: A 63-year-old man developed a 5-mm isolated lung metastasis 25 months after distal pancreatectomy for the primary cancer. He underwent an excisional biopsy for diagnosis and treatment. Although new lesions developed after this excision, additional extirpation of the chemotherapy-resistant tumor nodule realized a tumor-free survival for 15 months and total 74 months survival since pancreatectomy. Case 2: A 75-year-old man developed a 10-mm isolated lung metastasis of pancreatic cancer 13 months after distal pancreatectomy and underwent an excisional biopsy. In spite of adjuvant chemotherapy, 18 months later, a new lesion developed in the lung field neighboring the site of the first metastasis. He received a redo resection and has had a tumor-free period for 20 months until now. He has survived for 55 months since distal pancreatectomy. Aggressive excisional biopsy and repeated surgical resection could be recommended as a treatment option for isolated lung metastasis of pancreatic cancer.

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Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography and computed tomography (FDG-PET/CT)

Cited by 10 publications

References 30 publications

A Comparison of Positron Emission Tomography and Colonoscopy for the Detection of Advanced Colorectal Neoplasms in Subjects Undergoing a Health Check-Up

A Comparison of Positron Emission Tomography and Colonoscopy for the Detection of Advanced Colorectal Neoplasms in Subjects Undergoing a Health Check-Up

Quadruple Multiple Primary Malignancies: Early Detection of Second Primary Malignancy by Esophagogastroduodenoscopy/Colonoscopy Is Crucial for Patients with Classic Kaposi’s Sarcoma

Appraisal of Aggressive Excisional Biopsy for a Possible Isolated Lung Metastasis of Pancreatic Cancer: Repeated Extirpation Contributes to Long Survival

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