Positividade sorológica antiPGL-I em contatos domiciliares e peridomiciliares de hanseníase em área urbana

Leprosy is a public health problem in Brazil. Epidemiological control actions are based on the diagnosis and treatment of leprosy patients and household contact surveillance. Serological tests for leprosy could identify from among the contacts those at greater risk of developing leprosy in the future. ML Flow was administered to 2,840 household contacts of new leprosy cases diagnosed from October 2002 to March 2004, in State of Minas Gerais. ML Flow was positive in 20.5% of leprosy contacts, with high seropositivity among males (22.4%), individuals aged over 15 years-old (21.7%) and individuals in contact with multibacillary cases (23.9%). The chances of a household contact presenting a seropositive test was related to household contact with a multibacillary index case (OR=1.75), age over 15 years-old (OR=1.38) and male gender (OR=1.25). Follow-up of these contacts is necessary to evaluate the real role of seropositivity in the development of leprosy disease.

Section: Resultssupporting

confidence: 94%

Section: Resultsmentioning

confidence: 96%

Soroprevalência do teste ML Flow em contatos de hanseníase de Minas Gerais

Andrade

Grossi

Bührer-Sékula

et al. 2008

“…The proportion of seropositivity among contacts with a MB index case (22.6%) in this study was higher than that (18.4%) shown by Calado et al 4 . A study of the ML Flow test that included contacts conducted by Bührer-Sékula et al 3 made no mention of index cases.…”

contrasting

confidence: 83%

“…The majority of cases were PB, which is typical for this age group 5 7 12 18 . The percentage of seropositivity (19.7%) observed among the contacts of this study falls between those obtained in Bührer-Sékula et al 3 and Calado et al 4 , which were 28.6% and 15.6%, respectively. The Bührer-Sékula et al 3 study involved 42 household contacts and made no reference to the age of the individuals.…”

supporting

confidence: 72%

Fatores associados à soropositividade do teste ML Flow em pacientes e contatos de pacientes com hanseníase menores de 18 anos

Ferreira

Antunes

2008

This article presents the results of a cross-sectional study involving 115 newly-diagnosed leprosy patients and 1,011 household contacts, all under the age of 18. Seropositivity ratios and factors associated with a positive ML Flow were determined. The test was positive in 21.7% of patients and in 19.7% of contacts. Among patients, logistic regression indicated the association of seropositivity with positive slit skin smear and having more than five skin lesions. The tree method analysis indicated associations with skin smear, Madrid classification, number of nerves affected and age. In the contact group, index case classification, age and type of health service were associated with seropositivity in both analyses. The variables that best explained seropositivity are those associated with higher bacterial load. Therefore, the ML Flow test could be used in children to aid correct classification of patients for treatment and to identify contacts at greater risk of developing leprosy.

“…10 Another important indicator among the patients was the percentage of leprosy cases with household contacts (46.4%), 44.9% of them presenting a seropositive ML Flow test result. Other authors reinforce the necessity of detailed dermatoneurological examination of household contacts 5 , since, in Brazil, only a part of these contacts are examined 2 6 . Use of the ML Flow test helped the improve the diagnosis of suspected leprosy cases, since it is not yet part of the service routine, rather it provides support in the operational process of diagnosis aimed at reducing endemy in the district.…”

Section: Discussionmentioning

confidence: 91%

Uso do teste ML Flow em escolares diagnosticados com hanseníase no município de Paracatu, Minas Gerais

Ferreira

Evangelista

et al. 2008

The detection rate of leprosy in the district of Paracatu is high in the age group under 15 years-old, including about 6.8/10,000 inhabitants in 2003, and classified as hyperendemic. The study aimed to analyze the application of the PGL-1 (ML Flow) serological test in 56 of 68 school-age patients of the public school system, diagnosed with leprosy through active case finding in Paracatu, Minas Gerais State (2004State ( to 2006, with 71% classified as paucibacillary. Of these, 85.2% lived in urban areas, 55.8% were female and the disease was predominant in the 10 to 14 year-old age group (95%CI: 0.49-0.89; c