Positive Serum Ethanol Level and Mortality in Moderate to Severe Traumatic Brain Injury

Salim, Ali

doi:10.1001/archsurg.2009.158

Cited by 87 publications

(85 citation statements)

References 31 publications

(37 reference statements)

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“…The highest heterogeneity was noted between the studies by Chen et al 7 and Salim et al, 37 with an interstudy I 2 of 88% (c 2 = 8.54, p = 0.003). Two other studies that notably increased the heterogeneity were those by Talving et al 45 and Tien et al 47 These studies were excluded from the sensitivity analyses.…”

Section: Resultsmentioning

confidence: 87%

“…From the chosen abstracts a total of 11 full-text articles were fully reviewed. 1,3,4,6,7,22,37,38,41,45,47 Individual study characteristics are shown in Table 1. All studies included were considered to be of high quality by the Newcastle-Ottawa quality assessment scale ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Two other studies that notably increased the heterogeneity were those by Talving et al 45 and Tien et al 47 These studies were excluded from the sensitivity analyses. In the first sensitivity analysis the studies by Talving et al, 45 Tien et al, 47 and Salim et al 37 were excluded, resulting in a total of 55,949 patients, with an overall crude hospital mortality rate of 13.2% (BAC positive 12.2% vs BAC negative 14.0%). The pooled odds ratio was 0.87 (95% CI 0.83-0.92), with good study homogeneity (c 2 = 10.97, p = 0.14, I 2 = 36%).…”

Section: Resultsmentioning

confidence: 99%

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Alcohol and mortality after moderate to severe traumatic brain injury: a meta-analysis of observational studies

Raj¹,

Mikkonen

Siironen³

et al. 2016

JNS

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T raumaTic brain injury (TBI) is defined as an alteration of brain function, or other evidence of brain pathology, caused by an external force.28 Moderate to severe TBI is a major cause of mortality and morbidity in the world. 27 Every year approximately 1.5 million people die and 10 million people are hospitalized due to TBI. 18 This leads to great suffering for patients and their relatives, with huge direct and indirect costs to society. 10,32 It has been estimated that the annual costs of TBI in the US are more than $76.5 billion.9 Numerous clinical trials have failed to demonstrate the efficacy of promising experimental neuroprotective agents despite convincing preclinical data. Over the past 2 decades there have not been clear improvements in the prognosis of patients with TBI. 24,25 Description of the interventionUp to half of all patients with TBI are under the influence of alcohol at the time of injury. 44,49 Clinical studies investigating the role of alcohol (ethanol, CH 3 CH 2 OH, referred to as alcohol in the present study) on the outcome of TBI have been either retrospective or observational, as it probably would be unethical, unless strong evidence can be laid out, to administer alcohol to patients presenting with TBI. This meta-analysis investigates the impact of the presence of blood alcohol concentration (BAC) on outcome after TBI. How Might alcohol work as a Neuroprotective agent?The neuroprotective properties of alcohol have been abbreviatioNs AIS = Abbreviated Injury Scale; BAC = blood alcohol concentration; GCS = Glasgow Coma Scale; NMDAR = N-methyl-d-aspartate receptor; TBI = traumatic brain injury. but with good study homogeneity (I 2 = 36% and 14%). coNclusioNs Positive BAC was significantly associated with lower mortality rates in moderate to severe TBI. Whether this observation is due to selection bias or neuroprotective effects of alcohol remains unknown. Future prospective studies adjusting for TBI heterogeneity is advocated to establish the potential favorable effects of alcohol on outcome after TBI.

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Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Alcohol and mortality after moderate to severe traumatic brain injury: a meta-analysis of observational studies

Raj¹,

Mikkonen

Siironen³

et al. 2016

JNS

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“…Intoxicated people with isolated head injuries, alcohol may improve prognosis and mortality rate by its neuroprotective feature, even though the severity of such injuries is much higher than in sober people [23][24][25][26][27][28][29]. In cases of polytrauma injuries, their effect proved to be negative [30][31][32], and also increased the number of complications [25,26,32]. Moreover, it impairs psychomotor performance and concentration, causing a decrease in criticism and the ability of perception as well as proper judgement.…”

Section: Discussionmentioning

confidence: 99%

Are animal-related injuries in rural areas a social problem? A survey from Poland

Neskoromna-Jędrzejczak

Bogusiak

Kasielska‐Trojan

et al. 2017

Ann Agric Environ Med.

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Objective. The aim of this study was to analyze the mechanisms of animal-related injuries in Polish rural areas, and to evaluate the effects of such injuries on subjects' health and social life. Materials and method. Data concerning animal-related injuries were collected from 102 patients (45 females and 57 males, mean age 45.01±11.4 years) on the basis of a questionnaire. The study was conducted in the rural area of central Poland. Moreover, to assess the severity of injuries to the head and neck region, the Facial Injury Severity Scale (FISS) was applied. Results. The most commonly affected body areas are the upper and lower limbs, which explains the fact that most subjects do not recognize the injury-related deformity as an aesthetic defect.Statistical correlations were observed in several aspects, amongst others: -women were significantly more likely than men to consider undergoing surgical procedures to eliminate/reduce posttraumatic deformities and scars (p<0.05); -injury-related deterioration in appearance resulted in limitations of patients' social life (p<0.0001).

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“…1). Severe traumatic brain injuries were categorised according to the Glasgow Coma Scale (GCS) on mild TBI (13-15 GCS), moderate TBI (9-12 GCS) and severe TBI (3)(4)(5)(6)(7)(8). Most studies consider patients of moderate and/or severe TBI (3-12 GCS).…”

Section: Objectivementioning

confidence: 99%

Early Indicators of Prognosis in Traumatic Brain Injury and their Association with Outcome

Verma¹,

Gupta²,

Rappai³

et al. 2017

IOSR JDMS

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Positive Serum Ethanol Level and Mortality in Moderate to Severe Traumatic Brain Injury

Abstract: Serum ethanol is independently associated with decreased mortality in patients with moderate to severe head injuries. Additional research is warranted to investigate the potential therapeutic implications of this association.

Cited by 87 publications

References 31 publications

Alcohol and mortality after moderate to severe traumatic brain injury: a meta-analysis of observational studies

Alcohol and mortality after moderate to severe traumatic brain injury: a meta-analysis of observational studies

Are animal-related injuries in rural areas a social problem? A survey from Poland

Early Indicators of Prognosis in Traumatic Brain Injury and their Association with Outcome

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