Positive Role of Chinese Herbal Medicine in Cancer Immune Regulation

Wang, Sumei; Long, Shunqin; Deng, Zhiyin; Wu, Wanyin

doi:10.1142/s0192415x20500780

Cited by 144 publications

(94 citation statements)

References 76 publications

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“…In this study, the majority of participants reported the same purpose before (69.7%) / after (71.8%) the epidemic of COVID-19, as immune system has a close interaction with COVID-19 infection and cancer progression [22,23]. CAM was quite famous for its regulating immune system effect in cancer patients and fighting against COVID-19 [24,25], and cancer patients seemed to show more interest (70.2%) and confidence (79.4%) in CAM treatment during the COVID-19 though their frequency of CAM clinic visit dropped significantly.…”

Section: Discussionmentioning

confidence: 65%

The Changes of Cancer Patients' Perception, Attitude and Clinical Practice in Complementary and Alternative Medicine during COVID-19: A Multicenter Before-After Cross-Sectional Study

Wang

Yang

Zhan

et al. 2021

Preprint

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Background: With the rapid spread of COVID-19 worldwide, the clinical practice in cancer treatment of complementary and alternative medicine (CAM) becomes significantly different. This study was designed to explore the changes of China’s cancer patients’ perception, attitude and clinical practice in CAM after the pandemic of COVID-19. Methods: A multicenter before-after cross-sectional study was conducted, including 448 cancer patients by a survey. Results: For perception, half of the cancer patients (51.2%) reported they had received adequate information in CAM cancer treatment and had a great expectation in medical appointment pattern (40.2%). For attitudes, most of the cancer patients (79.4%) had full of confidence in CAM cancer treatment and showed a strong desire to learn more about CAM (70.2%). Nearly half of the cancer patients (44.0%) presented their oncology clinics had been greatly affected by COVID-19, however, most (82.8%) refused to the online medical service pattern. For clinical practice, Chinese herbal medicine was widely used before (89.5%) / after (90.3%) the epidemic of COVID-19 and the main purpose of receiving CAM therapy was to improve immune system (71.8%). The frequency of patients’ visiting the clinic decreased significantly (P < 0.001), and most (90.0%) didn’t change their follow-up pattern. The majority of the cancer patients (83.3%) were identified as CAM users and the only predictive factor was national health insurance in the multivariable logistic regression model. Conclusion: China’s cancer patients show more interest and confidence in treating cancer by CAM, and the new medical pattern such as medical appointment, has been gradually accepted during the COVID-19 pandemic. However, the cancer patients’ perception in CAM and online medical service pattern still need to be improved.

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Section: Discussionmentioning

confidence: 65%

The Changes of Cancer Patients' Perception, Attitude and Clinical Practice in Complementary and Alternative Medicine during COVID-19: A Multicenter Before-After Cross-Sectional Study

Wang

Yang

Zhan

et al. 2021

Preprint

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“…In the first study [30], there is significant improvement in chest discomfort, fullness and distension and shortness of breath, but not for palpitations and pain. Moreover, other authors consider the use of traditional Chinese medicine in the decrease of side effects caused by cancer treatments such as chemotherapy or radiotherapy [49]. In the second [39], there is a greater reduction in perioperative anxiety in both intervention groups, but not in the other factors to be studied.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Complementary Therapies in Cancer Patients: A Systematic Review

Guerra-Martín

Tejedor-Bueno

Correa-Casado

2021

IJERPH

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According to the World Health Organization, cancer is the second leading cause of death in the world. In Spain, about a quarter of a million cases were diagnosed in 2017, and 81% of the Spanish population has used, at least once, some kind of complementary therapy. Said therapies are increasingly being used by cancer patients. The purpose of the study is to analyse the effectiveness of complementary therapies among cancer patients. A systematic peer review was conducted following the PRISMA-ScR guide in four databases (PubMed, CINAHL, Scopus and WOS). The inclusion criteria were Randomised Clinical Trials, published between 2013 and 2018, with a value of 3 or more on the Jadad Scale. The protocol was registered in PROSPERO (CRD42019127593). The study sample amounted to 1845 patients (64.55% women), the most common being breast cancer patients (794), followed by lung cancer patients (341). Fifteen complementary therapies were identified. We found two studies for each of the following: electroacupuncture, phytotherapy, hypnotherapy, guided imagery and progressive muscle relaxation. From the remaining ones, we identified a study on each therapy. The findings reveal some effective complementary therapies: auriculotherapy and acupuncture, laser moxibustion, hypnosis, Ayurveda, electroacupuncture, progressive muscle relaxation and guided imagery, yoga, phytotherapy, music therapy and traditional Chinese medicine. On the other hand, electroacupuncture, laser moxibustion and traditional Chinese medicine presented adverse effects, and kinesiology did not show effectiveness.

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“…The same as below. 10 Oxidative Medicine and Cellular Longevity the concentration of serum CCL4 showed a marked decline in the G+F group, compared with the control group (Figure 3(g)). These results confirmed that MDSCs were one of the critical cell populations for the FZQX prescription to prevent the recurrence and metastasis of lung cancer.…”

Section: Mdscs Played a Key Role In The Inhibition Of Tumormentioning

confidence: 94%

“…In addition to surgery and chemotherapy, most Chinese patients seek help from traditional Chinese medicine (TCM) during or after standard first-line therapy. Numerous clinical trials have proved that TCM has its advantages in antitumors [ 9 , 10 ]. The effects of TCM in alleviating symptoms, reducing side-effects, and improving quality of life and adverse events caused by chemotherapy have been confirmed [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Chinese Herbal Prescription Fu‐Zheng‐Qu‐Xie Prevents Recurrence and Metastasis of Postoperative Early‐Stage Lung Adenocarcinoma: A Prospective Cohort Study Followed with Potential Mechanism Exploration

Zhang

Chen

Wang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Chinese herbal Fu-Zheng-Qu-Xie (FZQX) prescription has been found to improve the immune function and survival of patients with early-stage lung cancer. However, the therapeutic efficacy needs to be evaluated objectively, and the precise mechanism remains unclear. In the present study, a double-center, prospective cohort study was carried out to assess the clinical efficacy of the FZQX prescription in preventing the recurrence and metastasis of postoperative early-stage lung adenocarcinoma. Our results indicated that the FZQX prescription could significantly reduce the 3-year postoperative recurrence rate and improve the life quality. Moreover, the peripheral blood indices showed that the positive immune index (CD4+T/CD8+T) increased and the negative immune indices (CD8+T, Myeloid-derived suppressor cells (MDSCs), Treg) decreased after treatment with the FZQX prescription. Since the positive regulatory effect of the FZQX prescription on immune function, a series of experiments were conducted to verify the tumor-suppressive effect and elucidate the underlying mechanisms. Through the MDSC clearance xenograft model, we confirmed that the FZQX prescription could effectively suppress tumor growth with lesser side effects in vivo, and MDSCs may be involved in the biological process of the FZQX prescription’s intervention in lung cancer progression. By establishing the coculture system of MDSCs/LLC to simulate the immune microenvironment of lung cancer, the tumor suppression effect of the FZQX prescription was further validated by in vitro experiments. Besides, it was confirmed that the FZQX prescription could regulate MDSCs to remodel the immunosuppressive tumor microenvironment, thus exerting its preventive effect on relapse of lung cancer. Finally, the pathway activator and inhibitor were further used to explore the potential molecular mechanism. Results demonstrated that the IL-1β/NF-κB signaling pathway was one of the critical signaling pathways of FZQX prescription regulating MDSCs to prevent the recurrence and metastasis of lung adenocarcinoma.

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Positive Role of Chinese Herbal Medicine in Cancer Immune Regulation

Cited by 144 publications

References 76 publications

The Changes of Cancer Patients' Perception, Attitude and Clinical Practice in Complementary and Alternative Medicine during COVID-19: A Multicenter Before-After Cross-Sectional Study

The Changes of Cancer Patients' Perception, Attitude and Clinical Practice in Complementary and Alternative Medicine during COVID-19: A Multicenter Before-After Cross-Sectional Study

Effectiveness of Complementary Therapies in Cancer Patients: A Systematic Review

Chinese Herbal Prescription Fu‐Zheng‐Qu‐Xie Prevents Recurrence and Metastasis of Postoperative Early‐Stage Lung Adenocarcinoma: A Prospective Cohort Study Followed with Potential Mechanism Exploration

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