Positive impact of an emergency department protocol on time to antimicrobial administration in dogs with septic peritonitis

Abelson, Amanda L.; Buckley, Gareth; Rozanski, Elizabeth A.

doi:10.1111/vec.12092

Cited by 24 publications

(26 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are also limitations in directly comparing the survival rates of the RSSP group in this study and the survival rate reported by Barfield et al 9 with the survival rates for the general canine population treated for SSP reported in the literature (50−70%) 2‐6 . Until a study is performed that includes a larger RSSP group to allow a direct comparison, the available data suggest that survival for dogs treated surgically for RSSP is worse than for dogs treated for an initial episode of SSP.…”

Section: Discussionmentioning

confidence: 80%

“…In comparing the survival rates of the RSSP and NoRSSP groups, it is also worth noting that the survival rate of the NoRSSP group in this study was calculated after the exclusion of cases of intraoperative euthanasia. Thus, it is not directly comparable to the survival rate reported in previous studies in which cases of intraoperative euthanasia were included.There are also limitations in directly comparing the survival rates of the RSSP group in this study and the survival rate reported by Barfield et al 9 with the survival rates for the general canine population treated for SSP reported in the literature (50−70%) [2][3][4][5][6]. Until a study is performed that includes a larger RSSP group to allow a direct comparison, the available data suggest that survival for dogs treated surgically…”

mentioning

confidence: 79%

“…SSP is a life‐threatening condition in dogs that requires both exploratory surgery and intensive medical treatment. Reported survival rates for dogs treated for SSP vary, with recent studies reporting survival rates between 50% and 70% 2‐6 . Nonsurvivors typically succumb to complications related to dysfunction of 1 or more organ systems in the immediate postoperative period 2,6 …”

Section: Introductionmentioning

confidence: 99%

“…Reported survival rates for dogs treated for SSP vary, with recent studies reporting survival rates between 50% and 70%. [2][3][4][5][6] Nonsurvivors typically succumb to complications related to dysfunction of 1 or more organ systems in the immediate postoperative period. 2,6 Although there are a number of studies examining risk factors for survival following surgery for septic peritonitis in dogs, few studies have reported on the specific complication of recurrence of peritonitis among dogs treated for septic peritonitis.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Identification of risk factors for recurrent secondary septic peritonitis following initial surgical treatment of secondary septic peritonitis in dogs

Fink

Buysse

Drobatz

et al. 2020

J Vet Emergen Crit Care

View full text Add to dashboard Cite

Objectives To report the incidence of and risk factors for development of recurrent secondary septic peritonitis (RSSP) in dogs. To report the outcome of dogs treated surgically for RSSP. Design Retrospective study. Setting University teaching hospital. Animals One hundred forty‐nine client‐owned dogs treated surgically for secondary septic peritonitis (SSP). Interventions None. Measurements and Results The medical records database was searched for dogs that underwent surgery to treat SSP. Of 149 dogs that met the inclusion criteria, 15 (10.1%) dogs developed RSSP following surgery and 134 (89.9%) did not. Dogs with RSSP had significantly lower albumin prior to the first surgery to treat secondary septic peritonitis (SPsx1) (median 18 g/L [1.8 g/dL] vs 22 g/L [2.2 g/dL], P = 0.005) and significantly higher PCV prior to SPsx1 (median 52% vs 45%, P = 0.028). Dogs with septic peritonitis of gastrointestinal (GI) origin were significantly more likely to develop recurrent peritonitis than those with sepsis from a non‐GI source (odds ratio [OR], 4.4, 95% CI: 0.95–20, P = 0.041). Of dogs with sepsis of GI origin, those with sepsis due to a foreign body were significantly more likely to develop RSSP than those with GI sepsis from a non‐foreign body cause (OR, 7.2, 95% CI: 1.6–43, P = 0.0018). Of the 15 dogs in the RSSP group, 8 were euthanized without further treatment. Relaparotomy was performed in the remaining 7 cases; 3 of these (42.9%) survived. Conclusions There was a 10.1% rate of RSSP following SPsx1. Preoperative albumin was significantly lower and preoperative PCV was significantly higher in dogs that developed recurrence. Dogs with GI sepsis were at increased risk of recurrence and, among dogs with GI sepsis, the presence of a foreign body was an additional risk factor for recurrence.

show abstract

Section: Discussionmentioning

confidence: 80%

mentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Identification of risk factors for recurrent secondary septic peritonitis following initial surgical treatment of secondary septic peritonitis in dogs

Fink

Buysse

Drobatz

et al. 2020

J Vet Emergen Crit Care

View full text Add to dashboard Cite

show abstract

“…1,2 Studies in humans and dogs suggest that early and aggressive treatment of sepsis might improve survival and it is well documented in humans that early intervention with appropriate antimicrobials decreases morbidity and case fatality rate. 3,4 However, it remains challenging to promptly and accurately diagnose sepsis, as other inflammatory disease states appear similar and can share clinical and laboratory findings, and standard microbiological testing takes days to perform. Biomarkers have been shown to assist in the rapid diagnosis of sepsis in humans.…”

Section: Introductionmentioning

confidence: 99%

Serum procalcitonin concentrations in dogs with induced endotoxemia

Easley

Holowaychuk²,

Lashnits

et al. 2020

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background Procalcitonin (PCT) is an important biomarker for sepsis in human medicine, but there is little information regarding PCT as a biomarker for sepsis in dogs. There are no controlled studies evaluating serial concentrations of PCT in dogs. Hypothesis/Objective That PCT would be rapidly detectable in serum after injection of LPS and would remain increased for at least 24 hours. Objective was to evaluate serial serum PCT concentrations in dogs after a single IV injection of LPS compared to placebo. Animals Six healthy mixed breed dogs. Methods A nonrandomized, placebo‐controlled, crossover study was performed. Dogs were initially injected with placebo (0.9% NaCl; 1 mL, IV) and then experimental endotoxemia was induced by injecting lipopolysaccharide (LPS; 2 μg/kg, IV, once) after a 5‐day washout period. Serial blood samples were collected for measurement of serum PCT after each injection. Difference in median PCT concentration between serial time points was assessed using a mixed effects model. Results After LPS administration, blood pressure decreased and body temperature increased along with the development of lethargy, vomiting, and diarrhea. Procalcitonin was significantly increased compared to baseline by 2 hours after injection of LPS (median = 67.9 versus 172.8, range = 46.0‐74.1 versus 99.5‐295.9, P = .0002) and remained significantly increased for 12 hours (median = 205.9, range = 119.9‐297.4) with return to baseline by 48 hours. Procalcitonin was significantly higher than placebo 2, 4, 6, 8, 10, 12, and 24 hours after injection. There were no significant differences in PCT between time 0 and any of the subsequent time points in the saline group. Conclusions and Clinical Importance Procalcitonin expression is likely to be a clinically useful biomarker for sepsis in dogs and might have an additional role in prognostication and therapeutic decision‐making.

show abstract

Systemic Inflammatory Response Syndrome, Sepsis, and Multiple Organ Dysfunction Syndrome

Sharp

2018

Textbook of Small Animal Emergency Medicine

View full text Add to dashboard Cite

Positive impact of an emergency department protocol on time to antimicrobial administration in dogs with septic peritonitis

Abstract: The development of an emergency department antimicrobial protocol significantly decreased time to antimicrobial administration following identification of septic peritonitis in dogs.

Cited by 24 publications

References 15 publications

Identification of risk factors for recurrent secondary septic peritonitis following initial surgical treatment of secondary septic peritonitis in dogs

Identification of risk factors for recurrent secondary septic peritonitis following initial surgical treatment of secondary septic peritonitis in dogs

Serum procalcitonin concentrations in dogs with induced endotoxemia

Systemic Inflammatory Response Syndrome, Sepsis, and Multiple Organ Dysfunction Syndrome

Contact Info

Product

Resources

About