2020
DOI: 10.14309/ajg.0000000000000588
|View full text |Cite
|
Sign up to set email alerts
|

Positive Hepatitis B Core Antibody Is Associated With Cirrhosis and Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

Abstract: OBJECTIVES: Previous exposure to hepatitis B virus (HBV) may increase the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C. We aim to study the impact of previous HBV infection on the severity and outcomes of patients with nonalcoholic fatty liver disease (NAFLD). METHODS: This was a multicenter study of 489 patients with biopsy-proven NAFLD and 69 patients with NAFLD-related or cryptogenic HCC. Antihepatitis B core antibody (… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

2
40
3
3

Year Published

2020
2020
2024
2024

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 46 publications
(50 citation statements)
references
References 44 publications
2
40
3
3
Order By: Relevance
“…[13,14] Recently, a study highlighted the importance of anti-HBc in the progression of NAFLD to cirrhosis and HCC. [8] They found a higher incidence of cirrhosis, HCC, and cirrhotic complications in patients with NAFLD who were anti-HBc positive at a median follow-up of 6 years. Our results showed higher anti-HBc positivity with increasing fibrosis grade, significantly higher rates of anti-HBc in the cirrhotic group and patients with HCC but established no relationship between positive anti-HBc and liver-related complications, including HCC at a median follow-up of 4 years.…”
Section: Discussionmentioning
confidence: 94%
See 1 more Smart Citation
“…[13,14] Recently, a study highlighted the importance of anti-HBc in the progression of NAFLD to cirrhosis and HCC. [8] They found a higher incidence of cirrhosis, HCC, and cirrhotic complications in patients with NAFLD who were anti-HBc positive at a median follow-up of 6 years. Our results showed higher anti-HBc positivity with increasing fibrosis grade, significantly higher rates of anti-HBc in the cirrhotic group and patients with HCC but established no relationship between positive anti-HBc and liver-related complications, including HCC at a median follow-up of 4 years.…”
Section: Discussionmentioning
confidence: 94%
“…[7] Moreover, a relationship was reported between anti-HBc positivity and progression to cirrhosis and HCC in patients with MAFLD. [8] However, it has not been confirmed in a different population yet. This study aimed to investigate the relationship between anti-HBc positivity and liver-related outcomes, MAFLD progression to significant fibrosis and cirrhosis.…”
mentioning
confidence: 94%
“…Билирубин общ. (мкмоль/л) Bilirubin total, μmol/L 12 (10)(11)(12)(13)(14)(15)(16)5) 19 (14-32) <0,001…”
Section: Discussionunclassified
“…При этом сочетание НАЖБП с текущим или перенесенным гепатитом В прогностически неблагоприятно, поскольку связано с повышенным риском прогрессирования фиброза и тяжелых исходов (ЦП, ГЦК, смерть) [11,17].…”
Section: Discussionunclassified
See 1 more Smart Citation