Positive Effects of Protein Restriction in Patients With Chronic Kidney Disease

Eyre, Sintra; Attman, Per‐Ola; Haraldsson, Börje

doi:10.1053/j.jrn.2007.11.013

Cited by 15 publications

(9 citation statements)

References 34 publications

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“…These results were in consistent with earlier findings which confirmed that restriction in dietary protein intake has antioxidant effect in CKD in animals and human (Nankivell et al 1994 andStenvinkel et al 1998), effective in improvement of renal functions (Eyre et al 2008) and delaying the progression of renal disease and dialysis therapy (Brunori et al 2007). Medium protein diet ameliorates inflammation, suppresses oxidative stress and reduces proteinuria in chronic renal failure rats (Kim et al 2010).…”

Section: Resultssupporting

confidence: 92%

“…The increased in nitric oxide production is attributed to dietary arginine and that causes renal failure. Dietary protein restriction affected positively the progression of renal disease (Pedrini et al 1996) that may reduce decline in renal functions (Eyre et al 2008), alleviates uremic symptoms (Maroni and Mitch 1997), and delay dialysis therapy (Brunori et al 2007). Medium protein diet ameliorate inflammation; suppresses oxidative stress and proteinuria (Kim et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Efficacy of Medium Protein Diet, Turmeric and Arabic Gum on Chronic Renal Failure

Omar¹,

Kabil

2018

Alexandria Science Exchange Journal An International Quarterly

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Renal failure is accompanied by oxidative stress, which is caused by enhanced production of reactive oxygen species and impaired antioxidant defense. Turmeric and Arabic gum have antioxidant activities and medicinal properties. This study aimed to investigate the effect of two levels of turmeric and Arabic gum and their combination in the presence of medium protein diets on rats with chronic renal failure. A total of (54) rats weighting 200 ± 10g were fed on basal diet for 7 days for acclimatization. Rats divided into two main groups, the first main group (n=6) fed on basal diet for 8 weeks (Negative Control), while the second main group fed on basal diet containing2 % L-arginine (arginine diet) for 4 weeks to induce chronic renal failure then the second main group divided into 8 subgroups (n =6) for 4 weeks as following: Subgroup (1): fed on arginine diet containing 14% protein and used as a positive control group. Subgroup (2): fed on arginine diet containing 7% protein, and used medium protein diet group (MPD).Subgroups (3 and 4): fed on MPDs containing 3% and 6% Arabic gum, respectively. Subgroups (5 and 6): fed on MPDs containing 1% and 2% turmeric, respectively. Subgroup (7): fed on MPD containing 3% Arabic gum and 1% turmeric. Subgroup (8): fed on MPD containing 6% Arabic gum and 2% turmeric. During the experimental period, rats were weighted weekly, feed intake and body weight gain were recorded. At the end of experimental period, rats were scarified; blood samples were collected centrifuged and frozen until analysis. Creatinine, urea nitrogen and uric acid, total protein, Na, K, AST, ALT, glucose and lipid profile were measured. Our results concluded that, all experimental diets had a positive effect on renal functions and the other complications resulted from CRF either alone or combined with medium protein diet especially with high levels. This effect may be due to antioxidant potential of turmeric and Arabic gum.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Evaluation of the Efficacy of Medium Protein Diet, Turmeric and Arabic Gum on Chronic Renal Failure

Omar¹,

Kabil

2018

Alexandria Science Exchange Journal An International Quarterly

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“…Low protein diets implemented with dietetic input in pre-dialysis patients were found to reduce uraemic symptoms, reduce GFR deterioration significantly (4.5 mL/min vs 10 mL/min over 6 months) and delay TTD by 6 months. 20 These results are consistent with our study, which found a difference of approximately 7.5 months in delaying TTD. Uraemic symptoms are known to be primary predictors for dialysis initiation and all cause mortality.…”

Section: Discussionsupporting

confidence: 93%

“…Results: A cohort of 246 patients was identified. Median estimated glomerular filtration rate was 16mL/min per 1.73 m 2 (interquartile range = [13][14][15][16][17][18][19][20] at initial pre-dialysis clinic visit and 63% commenced dialysis during the study period. Only 41% of patients received dietetic consultation.…”

mentioning

confidence: 99%

The association between dietetic consultation and time to dialysis for patients attending a pre‐dialysis clinic: A retrospective cohort study

et al. 2019

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Aim A multidisciplinary approach, including dietetics, is considered the optimal model of care for dialysis preparation. Dietetic consultation (DC) focuses on symptom management and dietary changes to delay time to dialysis. Evidence of the effectiveness of DC on time to dialysis is limited. This study aimed to investigate the impact of DC on time to dialysis for patients attending a pre‐dialysis clinic. Methods A retrospective cohort study was designed to include all patients attending outpatient pre‐dialysis clinics at a large metropolitan renal service between January 2014 and March 2018. Time to dialysis (days) was compared between patients that received DC and those who did not. Cox proportional hazards analysis allowing for adjustment of differences and confounders was undertaken. Results A cohort of 246 patients was identified. Median estimated glomerular filtration rate was 16mL/min per 1.73 m2 (interquartile range = 13–20) at initial pre‐dialysis clinic visit and 63% commenced dialysis during the study period. Only 41% of patients received dietetic consultation. Significantly fewer patients needed to commence dialysis in the DC group compared to the no‐DC group (hazards ratio 0.63; 95% confidence interval (CI) 0.45–0.89; P = 0.008 Cox proportion hazard). The DC group commenced dialysis significantly later than the no‐DC group; 933 days (95% CI 832–1034) versus 710 days (95% CI 630–790) respectively, after the initial pre‐dialysis clinic visit; log–rank 0.005. Conclusion DC provided to patients attending a pre‐dialysis clinic was associated with a delayed time to dialysis. Standardised referral pathways to improve patient access to renal dietetic services are recommended to optimise care.

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“…Low protein diet (0.6–0.8 g/kg), the common treatment of chronic renal disease, has some beneficial effects on the progression of renal failure, inflammatory makers levels and coagulation proteins such as fibrinogen in nephropathic-diabetic patients [70–76]. …”

Section: Dietary Proteinmentioning

confidence: 99%

Dietary Treatment Options for Depression among Diabetic Patient, Focusing on Macronutrients

Haghighatdoost

Azadbakht

2013

Journal of Diabetes Research

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There is a bidirectional adverse association between diabetes and depression. The odds for experiencing depressive symptoms in diabetic patients are two times more than nondiabetic persons, and depression is an independent predictor for the onset of diabetes. However, depression has been approximately unrecognized and untreated in two-thirds of diabetic patients, which may lead to worsened diabetes complications. A cornerstone strategy for managing depression among diabetic patients is the use of diet to improve both health problems. Because of similar pathophysiology for chronic diseases and depression, it seems that similar dietary recommendations could be useful. However, few studies have been conducted among diabetic patients. Regarding the complications of diabetes such as renal diseases and coronary heart diseases, the proper range of various macronutrients should be clarified in depressed diabetic patients as well as the proper type of each macronutrient. In this paper, we reviewed the available data on the treatment of depression in diabetic patients.

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Positive Effects of Protein Restriction in Patients With Chronic Kidney Disease

Cited by 15 publications

References 34 publications

Evaluation of the Efficacy of Medium Protein Diet, Turmeric and Arabic Gum on Chronic Renal Failure

Evaluation of the Efficacy of Medium Protein Diet, Turmeric and Arabic Gum on Chronic Renal Failure

The association between dietetic consultation and time to dialysis for patients attending a pre‐dialysis clinic: A retrospective cohort study

Dietary Treatment Options for Depression among Diabetic Patient, Focusing on Macronutrients

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