Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress

Oliveira, Jade de; Hort, Mariana Appel; Moreira, Eduardo Luiz Gasnhar; Glaser, Viviane; Ribeiro‐do‐Valle, Rosa Maria; Prediger, Rui Daniel; Farina, Marcelo; Latini, Alexandra; de, Andreza Fabro

doi:10.1016/j.neuroscience.2011.09.009

Cited by 85 publications

(58 citation statements)

References 61 publications

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“…LDL receptor-deficient mice fed a cholesterol-enriched diet developed elevated LDL levels and consequently oxidative stress [121]. These observations extend to human studies.…”

Section: Oxidative Stress and Dyslipidemiasupporting

confidence: 59%

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

Bonomini¹,

Rodella²,

Rezzani³

2015

Aging and disease

467

307

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ABSTRACT:The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors associated with obesity and insulin resistance, is dramatically increasing in Western and developing countries. This disorder consists of a cluster of metabolic conditions, such as hypertriglyceridemia, hyper-low-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart diseases. One of the defects in metabolic syndrome and its associated diseases is excess of reactive oxygen species. Reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes. Such toxic reactions contribute significantly to the aging process. In this article we review current understandings of oxidative stress in metabolic syndrome related disease and its possible contribution to accelerated senescence.

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“…LDL receptor-deficient mice fed a cholesterol-enriched diet developed elevated LDL levels and consequently oxidative stress [121]. These observations extend to human studies.…”

Section: Oxidative Stress and Dyslipidemiasupporting

confidence: 59%

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

Bonomini¹,

Rodella²,

Rezzani³

2015

Aging and disease

467

307

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Section: Lipoprotein Receptors In the Cnsmentioning

confidence: 93%

“…LDLR−/− mice also show a decrease in learning and memory regardless of diet 43 . Cholesterol-enriched diets increase plasma cholesterol levels, which relate to an increase in oxidative stress, decrease in the mitochondrial complex I and II activities in the cerebral cortex, and cognitive impairment 43 . In aged LDLr−/− mice that are exposed to cholesterol-enriched diets earlier in life, antioxidant imbalance and oxidative damage are evident by a marked increase in lipid peroxidation and an increase in acetylcholinesterase activity in the prefrontal cortex.…”

Section: Lipoprotein Receptors In the Cnsmentioning

confidence: 93%

What are lipoproteins doing in the brain?

Wang

Eckel

2014

Trends in Endocrinology & Metabolism

182

146

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Lipoproteins in plasma transport lipids between tissues, however, only high density lipoproteins (HDL) appear to traverse the blood brain barrier; thus, lipoproteins found in the brain must be produced within the central nervous system. Apolipoproteins E (ApoE) and ApoJ are the most abundant apolipoproteins in the brain, are mostly synthesized by astrocytes and are found on HDL. In the hippocampus and other brain regions lipoproteins help regulate neurobehavioral functions by processes that are lipoprotein receptor-mediated. Moreover, lipoproteins and their receptors also have roles in the regulation of body weight and energy balance, i.e. through lipoprotein lipase (LPL) and the LDL receptor-related protein (LRP). Thus, understanding lipoproteins and their metabolism in the brain provides a new opportunity with potential therapeutic relevance.

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“…Esta é uma das razões pelas quais há níveis anormais de lipídeos na resistência à insulina. Elevados níveis de lipoproteína de baixa densidade ligada ao colesterol (LDL-c) e baixos níveis de HDL-c, além de aumentos nos níveis de proteína C reativa, também se relacionam com os radicais livres em diferentes estudos [29][30][31][32][33].…”

Section: /7unclassified

“…Observa-se elevação de marcadores de estresse oxidativo em modelos animais quando há níveis elevados de LDL-c e baixos níveis de HDL-c e, em seres humanos, observa-se elevação destes marcadores quando há hipertrigliceridemia e baixos níveis de HDL-c. Medicações hipocolesterolemiantes, como algumas estatinas, podem reduzir o estresse oxidativo porque aumentam a síntese de enzimas antioxidantes, como glutationa peroxidase, catalase e superóxido dismutase [3,29,31,35].…”

Section: /7unclassified

Aspectos oxidativos da síndrome metabólica e aterosclerose

Barbalho¹,

Quesada²,

Goulart³

et al. 2015

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. http://creativecommons.org/licenses/by/4.0/deed.pt_BR Aspectos oxidativos da síndrome metabólica e aterosclerose ABStRActAims: To review the literature on the current aspects of oxidative stress and its role in metabolic syndrome and in atherosclerosis. Methods:The study was performed in April and May 2015 and the following databases were used: PubMed, SciELO, and LILACS, including articles published from 2011 onwards. The following keywords were used: oxidative stress and atherosclerosis or oxidative stress and metabolic syndrome. Meta-analyses and clinical trials with a large sample size were preferred. Results: A total of 3,934 articles were available in the databases (PubMed 3,292; SciELO 588; and LILACS 54). Fifty-three articles were included in the review after eliminating double references and using the inclusion criteria. Conclusions: Biochemical and anthropometric findings characteristic of the metabolic syndrome are related to inflammatory processes and to oxidative stress which, in turn, are closely related to atherosclerosis. A better understanding of how the conditions that underlie metabolic syndrome predispose to oxidative stress may significantly contribute to the treatment of patients with cardiovascular disease in the future.KEY WORDS: metabolic syndrome x; oxidative stress; atherosclerosis.

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Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress

Cited by 85 publications

References 61 publications

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

What are lipoproteins doing in the brain?

Aspectos oxidativos da síndrome metabólica e aterosclerose

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