“…Conversely, factors that promote calcification include TNF-α, TGF-β, ROS, platelet-derived growth factor (PDGF), cadherin-11 (cad-11), the BMP-2/Smad pathway, klotho, IL-1, -4, and -6, oxidized and acetylated low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), leptin, advanced glycation end products, glucocorticoids, type I collagen, fibronectin, 25-hydroxycholesterol, 17β-estradiol, uremic serum, 1,25-dihydroxycholecalciferol, and cyclic adenosine monophosphate (cAMP) [ 117 , 120 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 ].…”