Positive and negative psychotropic effects of levetiracetam

Helmstaedter, C.; Fritz, Nora; Kockelmann, Edgar; Kosanetzky, N.; Elger, Christian E.

doi:10.1016/j.yebeh.2008.05.012

Cited by 108 publications

(86 citation statements)

References 27 publications

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“…LEV has unfavourable psychotropic / behavioural effects, particularly by inducing depression and aggressive behaviour [13]. This was also true in a group of patients with ID which was comparable to the nine patients presented in this paper [14].…”

Section: Resultssupporting

confidence: 80%

Efficacy of Zonisamide - Levetiracetam Comedication in Nine Adult Patients with Difficult to Treat Epilepsy and Intellectual Disability (A Case Series Report)

Martin¹,

Fahrbach²

2012

Macedonian Journal of Medical Sciences

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Aim: Few studies have concerned anticonvulsive combination therapies in epilepsies resistant to established antiepileptic drugs in monotherapy. We sought to delineate the effects of zonisamidelevetiracetam comedication (ZNS+LEV) in adults with intellectual disabilities (ID). Material and Methods:Nine adult patients with drug resistant epilepsies and ID were treated in a routine outpatient setting with LEV or ZNS in combination with other anticonvulsants first and in a combination of both of them (ZNS+LEV) thereafter. Seizure frequency and behavioural effects were recorded in patients treated who approved to benefit from the combination of both substances but not when treated with only either of them. Results:The longitudinal follow up of individual cases of patients with difficult to treat epilepsies and intellectual disabilitiy (ID) suggests that the combination of ZNS and LEV may be an effective and well tolerated option, even if LEV or ZNS alone or in either other combinations had failed to reduce seizure frequency. Conclusions:These findings may not be generalized but request to perform further controlled studies on the efficacy and tolerability of the anticonvulsive therapy of ZNS in combination with LEV.

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Section: Resultssupporting

confidence: 80%

Efficacy of Zonisamide - Levetiracetam Comedication in Nine Adult Patients with Difficult to Treat Epilepsy and Intellectual Disability (A Case Series Report)

Martin¹,

Fahrbach²

2012

Macedonian Journal of Medical Sciences

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“…Helmstaedter and colleagues, for example, reported that 59% of 228 consecutive outpatients prescribed levetiracetam reported behavioral changes compared to 9% of controls; of these, 37% reported negative changes in behavior and 22% positive changes 19. These side effects may also occur in persons with ID, in some cases to a higher frequency than that observed for the general epilepsy population.…”

Section: Behavioral Side Effects Of Antiepileptic Drugsmentioning

confidence: 99%

Behavioral disorder in people with an intellectual disability and epilepsy: A report of the Intellectual Disability Task Force of the Neuropsychiatric Commission of ILAE

et al. 2016

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SummaryThe management and needs of people with intellectual disability (ID) and epilepsy are well evidenced; less so, the comorbidity of behavioral disorder in this population. “Behavioral disorder” is defined as behaviors that are difficult or disruptive, including stereotypes, difficult or disruptive behavior, aggressive behavior toward other people, behaviors that lead to injury to self or others, and destruction of property. These have an important link to emotional disturbance. This report, produced by the Intellectual Disability Task Force of the Neuropsychiatric Commission of the ILAE, aims to provide a brief review of some key areas of concern regarding behavioral disorder among this population and proposes a range of research and clinical practice recommendations generated by task force members. The areas covered in this report were identified by experts in the field as being of specific relevance to the broad epilepsy community when considering behavioral disorder in persons with epilepsy and ID; they are not intended to be exhaustive. The practice recommendations are based on the authors’ review of the limited research in this field combined with their experience supporting this population. These points are not graded but can be seen as expert opinion guiding future research and clinical practice.

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“…These studies have been grouped by side effect domain and AED type. Five of the studies [ [35], [37], [38], [85]] examined only behavioural domains. One paper [40] looked at behaviour as well as functionality and one paper examined cognitive adverse events [48].…”

Section: Summary Of Studies With a Focus On Intellectual Disabilitymentioning

confidence: 99%

“…Table 2 summarizes studies identified which have a focus on intellectual disability. [16], [17], [18], [20]] whilst other studies showed no or little improvement [ [35], [82], [85] ] .…”

Section: Summary Of Studies With a Focus On Intellectual Disabilitymentioning

confidence: 99%

Measurement of side effects of anti-epileptic drugs (AEDs) in adults with intellectual disability: A systematic review

Copeland

Meek

Kerr

et al. 2017

Seizure

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Epilepsy AED Side-effect PROM Highlights Out of a total of 108 measures identified, only eight were appropriate for use with people with ID. Screening tools are available to assess AED side effects in general adult populations; there are only two measures specifically designed for use in ID populations. The focus of these measures is broader than side effects and so may not pick up the full range of side effects of importance in this group. Side effects of AEDs are inconsistently and inadequately measured in ID populations and are overly reliant on carer report. Overall side effect burden is therefore likely to be under-reported. There is a clear lack of established and validated assessment scales for patients with ID and epilepsy.Copeland et.al 3

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Positive and negative psychotropic effects of levetiracetam

Cited by 108 publications

References 27 publications

Efficacy of Zonisamide - Levetiracetam Comedication in Nine Adult Patients with Difficult to Treat Epilepsy and Intellectual Disability (A Case Series Report)

Efficacy of Zonisamide - Levetiracetam Comedication in Nine Adult Patients with Difficult to Treat Epilepsy and Intellectual Disability (A Case Series Report)

Behavioral disorder in people with an intellectual disability and epilepsy: A report of the Intellectual Disability Task Force of the Neuropsychiatric Commission of ILAE

Measurement of side effects of anti-epileptic drugs (AEDs) in adults with intellectual disability: A systematic review

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