Positional nystagmus in middle ear cholesteatoma with labyrinthine fistula

Jeong, Hamin; Lee, Dong−Han; Shin, Jung Eun; Kim, Chang-Hee

doi:10.1016/j.mehy.2020.110223

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…where is the cumulative drug release, is the replacement volume of dialyzate, is the total volume of released medium, is the concentration of the released solution at the time of the i-th sampling, is the total mass of drug in nanoparticles [ 17 ].…”

Section: Definition Of Relevant Conceptsmentioning

confidence: 99%

The Effect of Zbxz23ir-21 NANO(nanomaterials) Delivery Vector on Apoptosis and PTEN(phosphatase and tensin homolog deleted on chromosome ten)/PI3K(Intracellular phosphatidylinositol kinase)/AKT(related to the A and C kinase) in Children with CHOLESTEATOMA in Middle Ear

Zheng

Wang

et al. 2021

Bioengineered

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Cholesteatoma of the middle ear is a kind of cystic disease with clear boundary formed by the abnormal growth of keratosquamous epithelium in temporal bone. Cholesteatoma otitis caused by it is a common disease in otorhinolaryngology. The EPR effect promotes the selective distribution of macromolecular substances in tumor tissues, which can increase drug efficacy. The purpose of this paper is to prepare and deliver the mir34a small molecule regulator, rubine, by nanotechnology, and to deliver it to the cells successfully. It can passively target tumor tissue through EPR effect, and play its regulatory role on miR-34a, thus inhibiting the growth of cholesteatoma cells. The effects of nano delivery on apoptosis and PIEN/P13K/AKt of children with middle ear choledochoma were tested in this paper. The experimental results were conducted on cholesteatoma cells as cell lines and balb/c nude mice as experimental objects. The expression of PTEN/PI3K/AKT in experimental group and control group was detected by immunohistochemistry. Apoptosis was discussed by cell activity detection. The physical and chemical properties, encapsulation efficiency, drug release ability in vitro and antitumor activity of nanoparticles in vitro and in vivo were studied. The results of cell level experiments in vitro showed that free RUBINE caused about 15% apoptosis, which was not different from RC NPs. The results showed that the nanoparticles could improve the expression of miR-34 in the cells, and then regulate the expression of Bcl-2, Cdk6 and CyclinD1, and play the inhibitory effect of miR-34a on the proliferation and migration of tumor cells.

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Section: Definition Of Relevant Conceptsmentioning

confidence: 99%

The Effect of Zbxz23ir-21 NANO(nanomaterials) Delivery Vector on Apoptosis and PTEN(phosphatase and tensin homolog deleted on chromosome ten)/PI3K(Intracellular phosphatidylinositol kinase)/AKT(related to the A and C kinase) in Children with CHOLESTEATOMA in Middle Ear

Zheng

Wang

et al. 2021

Bioengineered

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“…The present study, to the best of our knowledge, reports the first case, which manifests SSNHL with vertigo as an initial presenting symptom of HIV infection. Another interesting finding was that postcontrast 3D FLAIR images showed enhancement of the cochlea, vestibule and semicircular canals in the affected ear, suggesting the breakdown of blood–labyrinth barrier in the perilymphatic space because of inner ear inflammation [7–11]. This is the first demonstration of blood–labyrinth barrier breakdown in a patient with HIV infection, and we assume that the inner ear inflammation may be caused by HIV/AIDS-associated opportunistic infections.…”

mentioning

confidence: 60%

Sudden sensorineural hearing loss with vertigo as an initial presenting symptom of HIV/AIDS patient

Lee

Shin²,

Kim³

2021

Aids

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“…The most susceptible site of fistula formation is the lateral semicircular canal, implicated in approximately 90 per cent of cases 4 because of its anatomical proximity to the cholesteatoma. Because of the connection between the vestibular system and the cochlear, the symptoms directly attributable to a labyrinthine fistula are primary vestibular dysfunction 5 and sensorineural hearing loss. Other symptoms include otorrhoea and otalgia, secondary to infection of the cholesteatoma and chronic otitis media.…”

Section: Introductionmentioning

confidence: 99%

Post-operative vestibular and equilibrium evaluation in patients with cholesteatoma-induced labyrinthine fistulas

et al. 2023

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Objective This study aimed to compare the pre- and post-operative vestibular and equilibrium functions of patients with cholesteatoma-induced labyrinthine fistulas who underwent different management methods. Methods Data from 49 patients with cholesteatoma-induced labyrinthine fistulas who underwent one of three surgical procedures were retrospectively analysed. The three management options were fistula repair, obliteration and canal occlusion. Results Patients underwent fistula repair (n = 8), canal occlusion (n = 18) or obliteration procedures (n = 23). Patients in the fistula repair and canal occlusion groups suffered from post-operative vertigo and imbalance, which persisted for longer than in those in the obliteration group. Despite receiving different management strategies, all patients achieved complete recovery of equilibrium functions through persistent efforts in rehabilitation exercises. Conclusion Complete removal of the cholesteatoma matrix overlying the fistula is reliable for preventing iatrogenic hearing deterioration due to unremitting labyrinthitis. Thus, among the three fistula treatments, obliteration is the optimal method for preserving post-operative vestibular functions.

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Positional nystagmus in middle ear cholesteatoma with labyrinthine fistula

Cited by 3 publications

References 25 publications

The Effect of Zbxz23ir-21 NANO(nanomaterials) Delivery Vector on Apoptosis and PTEN(phosphatase and tensin homolog deleted on chromosome ten)/PI3K(Intracellular phosphatidylinositol kinase)/AKT(related to the A and C kinase) in Children with CHOLESTEATOMA in Middle Ear

The Effect of Zbxz23ir-21 NANO(nanomaterials) Delivery Vector on Apoptosis and PTEN(phosphatase and tensin homolog deleted on chromosome ten)/PI3K(Intracellular phosphatidylinositol kinase)/AKT(related to the A and C kinase) in Children with CHOLESTEATOMA in Middle Ear

Sudden sensorineural hearing loss with vertigo as an initial presenting symptom of HIV/AIDS patient

Post-operative vestibular and equilibrium evaluation in patients with cholesteatoma-induced labyrinthine fistulas

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