Positional and ultrastructural changes in peripheral pulp capillaries correlate with the active phase of dentin deposition and mineralization in rat molars

Immunolocalization of podoplanin/E11/gp38, CD44, and endomucin in the odontoblastic cell layer of murine tooth germs

“…Yoshida and Ohshima (27,41) have described that when dentin deposition begins, capillaries begin to invade into the odontoblast layer and finally settle close to the predentin while continuous capillaries form a coarse vascular network distant from the odontoblast layers, e.g., sub-odontoblastic layers. Therefore, they have suggested that the changes in the peripheral capillaries are closely related to the secretory activity of odontoblasts (27,35,41). Thus, the distribution patterns of peripheral blood vessels appear to be related to the cellular activities of mature odontoblasts and cells in sub-odontoblastic layers.…”

Role of osteopontin in the process of pulpal healing following tooth replantation in mice

“…Pulpal nerve fibers exhibit neuroplasticity with sprouting, degenerative, or regenerative processes depending on various scenarios, such as injury or physiological events [ [4] , [5] , [6] , [7] , [8] ]. The response of blood vessels is to initiate angiogenic events as a consequence of hypoxia, because the secretory activity of the odontoblasts is associated with the positional and ultrastructural changes of pulpal capillaries [ 9 ]. The mechanisms that regulate multi-event responses with tertiary dentinogenesis, reinnervation, and revascularization within the dental pulp following exogenous injury remain to be fully elucidated.…”