Positional Alcohol Nystagmus in Patients with Unilateral and Bilateral Labyrinthine Destructions

Aschan, Gunnar; Bergstedt, M; Goldberg, Leonard

doi:10.1159/000104105

Cited by 33 publications

(12 citation statements)

References 2 publications

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“…Subjective symptoms of alcoholic inebriation, such as dizziness and nausea, are also closely related to the intensity of PAN (3). Aschan et al (4) suggested that PAN is due to a dual nervous mechanism including a central and peripheral component and thus involves at least one functioning labyrinth. Money & Myles (25,26) suggested that PAN is caused by the low specific weight (0.8) of alcohol changing the buoyancy of the cupula in the inner ear endolymph.…”

Section: Discussionmentioning

confidence: 99%

Effects of xylene and alcohol on vestibular and visual functions in man.

Savolainen¹,

Riihimäki²,

Vaheri³

et al. 1980

Scand J Work Environ Health

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Section: Discussionmentioning

confidence: 99%

Effects of xylene and alcohol on vestibular and visual functions in man.

Savolainen¹,

Riihimäki²,

Vaheri³

et al. 1980

Scand J Work Environ Health

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“…Acute tolerance has been described for many drugs acting on the cardiovascular system (such as sympathomimetic amines [1,2] or cardiac nitrates [3,4]) and on the central nervous system (such as alcohol [5][6][7]). Apparent acute tolerance to cardiovascular effects of nicotine has been reported in the course of a 30-min infusion in people (8,9).…”

Section: Introductionmentioning

confidence: 99%

“…An infusion of nicotine bitartrate, 25 Mg (nicotine base)/kg per min, was given over 1 min. Blood samples (1 ml each) for nicotine concentration were drawn simultaneously at the three sampling sites at 1,3,5,7,10,15,20,30,45, and 60 min. At the end of the experiment the animals were killed.…”

Section: Introductionmentioning

confidence: 99%

Apparent tolerance to the acute effect of nicotine results in part from distribution kinetics.

Porchet¹,

Benowitz²,

Sheiner³

et al. 1987

J. Clin. Invest.

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Persons exposed to nicotine develop tolerance to many of its effects. When heart rate and forearm venous blood concentration are plotted against time after intravenous administration of nicotine, a greater increase in heart rate is seen for-a given nicotine concentration during the rising phase of nicotine. concentrations than during the decreasing phase. This could be due to acute tolerance or to more rapid distribution of drug to effect site (brain) than to venous blood. To distinguish between these possibilities, six rabbits were given nicotine intravenously. Blood samples were taken from the internal jugular vein (reflecting brain concentration), and the femoral vein and artery. Brain concentrations peaked before femoral venous concentrations. Seven men received intravenous infusions of nicotine. Peripheral venous blood concentrations and cardiovascular responses were measured. Heart rate peaked before venous concentrations. A physiological kinetic model, fit to the rabbit data, was scaled to humans and used to predict "brain" concentrations in them. Heart rate and predicted brain concentrations peaked simultaneously. We conclude that the rapid development of tolerance to the cardioaccelerating effect of nicotine can be attributed, at least in part, to its distribution kinetics.

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“…(1). Records were obtained at 30, 60, 120, 180, 270, 360, 420, and 480 minutes after alcohol intake, while subjects were supine on a couch with the head in alternate left and right positions.…”

Section: Experiments I Pr Oc E D U R E Subjectsmentioning

confidence: 99%

“…Rychomotor skills Vestibular function 1. ORIGINATING ACTIVITY Enter the name and address of the contractor, subcontractor, grantee, Department of Def e n s e activity or other organization (corporate author) issuing t h e report.…”

Section: I N K B Abstract R O L E 1 W T R O L E W Tmentioning

confidence: 99%