Effects of xylene and alcohol on vestibular and visual functions in man.

Savolainen, Kai; Riihimäki, Vesa; Vaheri, Eero; Linnoila, Markku

doi:10.5271/sjweh.2628

Cited by 32 publications

(16 citation statements)

References 14 publications

(16 reference statements)

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“…These increases in body sway after alcohol occur in a dose-dependent manner. 29,30 In contrast, alcohol significantly decreased overall body sway in our patient with OT, particularly in the LAT plane. A functionally important response to alcohol, thus, may be present in both OT and ET, and is also consistent with a role for the cerebellum in both conditions.…”

Section: Discussionmentioning

confidence: 53%

Sway patterns in a case of orthostatic tremor responsive to alcohol

2004

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We describe changes in the extent of sway in a man with orthostatic tremor (OT) who reported increased stability after alcohol. He was tested at baseline and again after 40 g (0.5 g/kg) of alcohol. These results were compared to those of 3 age-matched controls (no alcohol). The patient's baseline sway was greater than controls, larger in the lateral than the anteroposterior plane, but retained normal responsiveness to the use of external support, increasing stance width, and vision. Tremor frequency significantly decreased after alcohol, as did low- and high-frequency tremor amplitude and the extent of body sway. Despite these findings, sway remained greater than controls. OT thus may show functionally important alcohol responsiveness.

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Section: Discussionmentioning

confidence: 53%

Sway patterns in a case of orthostatic tremor responsive to alcohol

2004

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“…Eine Beeinträchti-gung des Gleichgewichts trat aber bei der anschließenden Exposition gegenüber 880 mg/m 3 über 3 h mit 10-min-Spitzen von 1760 mg/m 3 auf [51]. Eine vierstündige Exposition mit 640 mg/m 3 oder 1200 mg/m 3 hatte bei 10 Probanden keinen Einfluss auf Gleichgewichtssinn und Flimmerverschmelzungsfrequenz [52]. Dagegen wurden Gleichgewichtssinn und Sehfähigkeit durch 4 h Exposition gegenüber 880 mg m-Xylol/m 3 beeinträch-tigt [53,54], bei 640 mg m-Xylol/m 3 waren die Effekte auf den Gleichgewichtssinn nicht konsistent und die Sehfähig-keit nicht beeinflusst [52,55].…”

Section: Irritative Wirkungenunclassified

Richtwerte für Dimethylbenzole in der Innenraumluft

Umweltbundesamtes¹

2015

Bundesgesundheitsbl.

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“…For example, research has demonstrated impairment of standing balance in healthy human volunteers after consumption of alcohol (e.g. Kubo et al, 1989;Modig et al, 2012a,b;Savolainen et al, 1980). The greatest deficits typically occur on tasks thought to rely on vestibular input, i.e.…”

Section: Introductionmentioning

confidence: 99%

The effect of alcohol on cervical and ocular vestibular evoked myogenic potentials in healthy volunteers

Rosengren

Weber

Hegemann

et al. 2014

Clinical Neurophysiology

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OBJECTIVE: We investigated the effect of alcohol on the cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs). As alcohol produces gaze-evoked nystagmus (GEN), we also tested the effect of nystagmus independent of alcohol by recording oVEMPs during optokinetic stimulation (OKS). METHODS: The effect of alcohol was tested in 14 subjects over multiple rounds of alcohol consumption up to a maximum breath alcohol concentration (BrAC) of 1.5‰ (mean 0.97‰).The effect of OKS was tested in 11 subjects at 5, 10 and 15deg/sec. RESULTS: oVEMP amplitude decreased from baseline to the highest BrAC level by 27% (range 5-50%, P<0.001), but there was no significant effect on oVEMP latency or cVEMP amplitude or latency. There was a significant negative effect of OKS on oVEMP amplitude (16%, P=0.006). CONCLUSIONS: We found a selective effect of alcohol on oVEMP amplitude, but no effect on the cVEMP. Vertical nystagmus elicited by OKS reduced oVEMP amplitude. SIGNIFICANCE: Alcohol selectively affects oVEMP amplitude. Despite the effects of alcohol and nystagmus, both reflexes were reliably recorded in all subjects and conditions. An absent response in a patient affected by alcohol or nystagmus indicates a vestibular deficit.

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Effects of xylene and alcohol on vestibular and visual functions in man.

Cited by 32 publications

References 14 publications

Sway patterns in a case of orthostatic tremor responsive to alcohol

Sway patterns in a case of orthostatic tremor responsive to alcohol

Richtwerte für Dimethylbenzole in der Innenraumluft

The effect of alcohol on cervical and ocular vestibular evoked myogenic potentials in healthy volunteers

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