Position Paper: Oral Features of Mucocutaneous Disorders

Abstract

Part of periodontology involves the diagnosis and treatment of a variety of non-plaque-related diseases of the periodontium. The International Workshop for a Classification of Periodontal Diseases and Conditions noted that the periodontist may be called upon to manage non-plaque-related mucocutaneous disorders either alone, or as part of a treatment team consisting of physicians, dentists or other allied health care professionals. This informational paper will review the etiology, clinical manifestations, diagnosis, and treatment of the most common chronic mucocutaneous diseases, including those that may present as desquamative gingivitis or intraoral vesiculobullous lesions. This paper is intended for the use of periodontists and other members of the dental profession.

Radiographic assessment of photodynamic therapy as an adjunctive treatment on induced periodontitis in immunosuppressed rats

“…Corticoids can lead to healing process delay by decreasing angiogenesis and capillary proliferation, which reduces blood flow 14 . They also interfere in phagocytosis and antigen digestion, inhibiting macrophage migrations and stabilizing lysosomes, avoiding proteolytic enzymes release.…”

“…Animals were then divided into 2 groups: D group (n=60), which received injections of 2 mg/kg body weight 15 of dexamethasone (DeCADRON ® 2 mg, Prodome, Aché Pharmaceutical Laboratories SA, Campinas, SP, Brazil); and ND group (n=60), which received injections of 2 mg/kg body weight 14 of saline. The subcutaneous injections were initiated 24 h before the experimental induction of periodontal disease and maintained every 3 days 6 , during all the study period.…”

“…The use of corticoids can provoke from gingival ulceration up to downward migration of the epithelium, attachment loss and transeptal fiber disruption 6 . In addition, the systemic use of high doses of glucocorticoids leads to fibroblast activity inhibition, collagen and connective tissue loss, with decreasing rereepithelization and angiogenesis 14 , reduction of number and activity of the osteoblasts, and increasing osteoclast function 18 . However, clinical studies are somewhat equivocal with respect to the effect of systemic glucocorticoids on periodontal tissues 13 .…”