Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials

Chiavaroli, Laura; Nishi, Stephanie K.; Khan, Tauseef; Braunstein, Catherine R.; Glenn, Andrea J.; Mejía, Sonia Blanco; Rahelić, Dario; Kahleová, Hana; Salas‐Salvadó, Jordi; Jenkins, David; Kendall, Cyril W.C.; Sievenpiper, John L.

doi:10.1016/j.pcad.2018.05.004

Cited by 137 publications

(104 citation statements)

References 64 publications

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“…1). However, in line with several previous studies [16,17], the LDL-C reduction was higher in the P-MedDiet group than in the control groups (-13%, -14%, and -25% in the MedDiet alone, MedDiet+SEY, and P-MedDiet, respectively) ( Fig. 1).…”

Section: Discussionsupporting

confidence: 91%

“…The P-Diet, which includes a combination of ingredients with cholesterol-lowering properties (such as plant sterols/stanols, fibres from oats and barley, nuts and soy products), is a recognised alternative approach lowering cholesterol by 20% to 30% in individuals with hyperlipidemia [16]. In this study we assessed the feasibility of a new dietary approach to lowering cholesterol, combining a MedDiet with a P-Diet (resulting in a P-MedDiet).…”

Section: Discussionmentioning

confidence: 99%

“…LDL-C can be reduced further through a combination of ingredients with cholesterol-lowering properties, such as plant sterols/stanols, viscous plant fibres from oats, barley, and nuts, soymilk, and soy meat analogues. This leads to an LDL-C reduction from 20% to 30% and a triglyceride reduction of 16% in individuals with hyperlipidemia compared with diet alone [16]. This dietary intervention, namely the Portfolio Diet (P-Diet) is now a recognised approach to lowering cholesterol [17].…”

Section: Introductionmentioning

confidence: 99%

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Effects of a Portfolio-Mediterranean Diet and a Mediterranean Diet with or without a Sterol-Enriched Yogurt in Individuals with Hypercholesterolemia

et al. 2020

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Background: A growing number of functional foods have been proposed to reduce cholesterol levels and the Portfolio Diet, which includes a combination of plant sterols, fibres, nuts, and soy protein, reduces low density lipoprotein cholesterol (LDL-C) from 20% to 30% in individuals with hyperlipidaemia. In this pilot study, the aim was to investigate whether a Mediterranean Diet incorporating a new and simple combination of cholesterol-lowering foods, excluding soy and nuts (namely the Portfolio-Mediterranean Diet), would reduce LDL-C levels, in the short-term, better than a Mediterranean Diet plus a sterol-enriched yogurt or a Mediterranean Diet alone. Methods: We retrospectively evaluated 24 individuals on a Portfolio-Mediterranean Diet and 48 matched individuals on a Mediterranean Diet with or without a sterol-enriched yogurt (24 each groups) as controls. Results: At follow-up (after 48±12 days), we observed an LDL reduction of 21±4, 23±4, and 44±4 mg/dL in the Mediterranean Diet alone, Mediterranean Diet plus yogurt and Portfolio-Mediterranean Diet respectively (P<0.001). Conclusion: A Portfolio-Mediterranean Diet, incorporating a new combination of functional foods such as oats or barley, plant sterols, chitosan, and green tea but not soy and nuts, may reduce LDL of 25% in the short term in individuals with hypercholesterolemia.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of a Portfolio-Mediterranean Diet and a Mediterranean Diet with or without a Sterol-Enriched Yogurt in Individuals with Hypercholesterolemia

et al. 2020

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“…Additionally, a lower rate of stroke mortality among vegetarian men relative to omnivore men was found, but the association was not significant among women [104]. Wang et al found in their meta-analysis of randomized-controlled trials that vegetarian diets are significantly lower in LDL-C, HDL-C, and total cholesterol relative to a range of omnivorous control diets [105]. Vegetarian diets lower blood pressure to a larger extent than omnivorous diets, Yokoama et al found [106].…”

Section: Plant-based Dietsmentioning

confidence: 99%

Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity

et al. 2020

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Although cardiovascular disease and its risk factors have been widely studied and new methods of diagnosis and treatment have been developed and implemented, the morbidity and mortality levels are still rising-cardiovascular disease is responsible for more than four million deaths each year in Europe alone. Even though nutrition is classified as one of the main and changeable risk factors, the quality of the diet in the majority of people does not follow the recommendations essential for prevention of obesity and cardiovascular disease. It demonstrates the need for better nutritional education in cardiovascular disease prevention and treatment, and the need to emphasize dietary components most relevant in cardiovascular disease. In our non-systematic review, we summarize the most recent knowledge about nutritional risk and prevention in cardiovascular disease and obesity.

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“…Results were comparable to a very low saturated fat diet that was supplemented with 20 mg of lovastatin, a cholesterol-lowering drug [41]. More recently, the Portfolio diet was associated with a 13% risk reduction of coronary heart disease after 10 years [42]. Thus, the positive association between plant-based diet adherence and heart health is an important finding for the nearly 50% of Black adults who already have some form of heart disease [43].…”

Section: Heart Diseasementioning

confidence: 80%

The Potential for Plant-Based Diets to Promote Health Among Blacks Living in the United States

Sterling

2019

Nutrients

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Plant-based diets are associated with reduced risks of various chronic diseases in the general population. However, it is unclear how these benefits translate to Blacks living in the United States, who are disproportionately burdened with heart disease, cancer, diabetes, obesity, and chronic kidney disease. The objectives of this study were to: (1) review the general evidence of plant-based diets and health outcomes; (2) discuss how this evidence translates to Blacks following a plant-based diet; and (3) provide recommendations and considerations for future studies in this area. Interestingly, although the evidence supporting plant-based diets in the general population is robust, little research has been done on Blacks specifically. However, the available data suggests that following a plant-based diet may reduce the risk of heart disease and possibly cancer in this population. More research is needed on cardiovascular disease risk factors, cancer subtypes, and other chronic diseases. Further, attention must be given to the unique individual, familial, communal, and environmental needs that Blacks who follow plant-based diets may have. Interventions must be culturally appropriate in order to achieve long-term success, and providing low-cost, flavorful, and nutritious options will be important.

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Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials

Abstract: Current evidence demonstrates that the Portfolio dietary pattern leads to clinically meaningful improvements in LDL-C as well as other established cardiometabolic risk factors and estimated 10-year CHD risk.

Cited by 137 publications

References 64 publications

Effects of a Portfolio-Mediterranean Diet and a Mediterranean Diet with or without a Sterol-Enriched Yogurt in Individuals with Hypercholesterolemia

Effects of a Portfolio-Mediterranean Diet and a Mediterranean Diet with or without a Sterol-Enriched Yogurt in Individuals with Hypercholesterolemia

Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity

The Potential for Plant-Based Diets to Promote Health Among Blacks Living in the United States

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