2006
DOI: 10.1016/j.jss.2006.03.042
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Portal Triad Occlusion Induces Endotoxin Tolerance: Role of Portal Congestion

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Cited by 11 publications
(13 citation statements)
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References 30 publications
(37 reference statements)
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“…These results are in agreement with other studies demonstrating that liver I/R plays an important role in cytokine liberation (Unno et al 2006;Sehirli et al 2008). On the other hand, when the integrity of the intestinal mucosal barrier is damaged, TNF-a and IL-1b levels are also increased (Yuan et al 2011).…”
Section: Discussionsupporting
confidence: 94%
“…These results are in agreement with other studies demonstrating that liver I/R plays an important role in cytokine liberation (Unno et al 2006;Sehirli et al 2008). On the other hand, when the integrity of the intestinal mucosal barrier is damaged, TNF-a and IL-1b levels are also increased (Yuan et al 2011).…”
Section: Discussionsupporting
confidence: 94%
“…Intestinal hypoperfusion leads to enterocyte damage and gut barrier loss [8]. The effect of splanchnic hypoperfusion on intestinal damage as a consequence of IPM has been proven in several animal studies [9][11]. Sheen-Chen et al [12] showed recently in rats that occlusion of the hepatoduodenal ligament significantly increased jejunal apoptosis.…”
Section: Introductionmentioning
confidence: 99%
“…The use of pigs in our study was based on the advantages they offer regarding availability and somatometric characteristics comparable to humans [10]. Portocaval shunt was rendered mandatory to avoid splanchnic congestion as a contributing factor to the observed results [11,12]. The 70-80% resection was selected in order to simulate harsh conditions for the liver, which became extreme with the implication of I/R process; besides, a 85% resection is considered the limit beyond which the hepatic remnant cannot exert its metabolic function or regenerate [13,14].…”
Section: Discussionmentioning
confidence: 99%