Heparin-binding epidermal growth factor-like growth factor protects rat intestine after portal triad clamping

Liao, Xinxin; Chen, Liyan; Fu, Wenguang; Zhou, Jie

doi:10.3109/08977194.2013.784757

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Frontiers in Physiology frontiersin.org level, and apoptosis index in mice (Liao et al, 2013), suggesting that HB-EGF may protect against intestinal inflammatory diseases, which is also consistent with our results. Therefore, we speculate that HB-EFG was negatively associated with constipation because it is a protective factor for IBD.…”

Section: Discussionsupporting

confidence: 91%

“… Zhou et al (2022) found that HB-EGF significantly reduces TNF-induced intestinal epithelial cell death in vitro and also synergizes with ErbB1 signaling to prevent cell death ( Zhou et al, 2022 ). In addition, an animal experiment using HB-EGF confirmed that intraluminal HB-EGF injection significantly reduces intestinal tissue damage, pro-inflammatory cytokine expression, myeloperoxidase activity, malondialdehyde level, and apoptosis index in mice ( Liao et al, 2013 ), suggesting that HB-EGF may protect against intestinal inflammatory diseases, which is also consistent with our results. Therefore, we speculate that HB-EFG was negatively associated with constipation because it is a protective factor for IBD.…”

Section: Discussionsupporting

confidence: 91%

“…HB-EGF is a member of the EGF family with strong heparin-binding ability. It primarily promotes mitosis of various cells such as fibroblasts, smooth muscle cells, and epithelial cells ( Liao et al, 2013 ). We found that proHB-EGF is inversely associated with constipation.…”

Section: Discussionmentioning

confidence: 99%

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The causal associations between growth factors and constipation: a two-sample Mendelian randomization study

Wang

Yang

et al. 2023

Front. Physiol.

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Introduction: Certain growth factors (GFs) are associated with constipation, but few studies has analyzed the causal associations between the two. Therefore, this study used two-sample Mendelian randomization (MR) to systematically analyze the causal associations between GF levels and constipation based on data from genome-wide association studies (GWAS).Methods: Both GF and constipation data were obtained from European populations. GFs, as an exposure variable, were obtained from a genetic map of the human plasma proteome containing 3,301 samples, another GWAS dataset on 90 circulating proteins containing 30,931 samples, and a GWAS dataset containing 3,788 samples. Constipation, as an outcome variable, was obtained from the FinnGen project containing 26,919 cases and 282,235 controls and another UK Biobank dataset containing 3,328 cases and 459,682 controls. Single-nucleotide polymorphisms strongly associated with GFs were regarded as instrumental variables. Inverse-variance weighting, MR–Egger regression, weight median, simple mode, and weight mode methods were used to determine genetic associations. Cochran’s Q test, Egger intercept, and Mendelian Randomization Pleiotropy RESidual Sum and Outlier tests were used to analyze sensitivity.Results: The IVW analysis based on FinnGen showed that NGFI-A-binding protein 2 and vascular endothelial growth factor receptor 2 were inversely associated with constipation, and that fibroblast growth factor 7 and transforming growth factor beta receptor II levels were positively associated with constipation. The IVW analysis based on UK Biobank showed that proheparin-binding epidermal growth factor, platelet-derived growth factor AA, and vascular endothelial growth factor121 were inversely associated with constipation.Conclusion: This study showed that some GFs are genetically associated with the risk of constipation.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

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The causal associations between growth factors and constipation: a two-sample Mendelian randomization study

Wang

Yang

et al. 2023

Front. Physiol.

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Role of antiviral therapy in reducing recurrence and improving survival in hepatitis B virus-associated hepatocellular carcinoma following curative resection (Review)

Zuo

Xia

et al. 2014

Oncology Letters

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Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related mortality worldwide, with the majority of cases associated with persistent hepatitis B virus (HBV) or hepatitis C virus infection. In particular, chronic HBV infection is a predominant risk factor for the development of HCC in Asian and African populations. Hepatic resection, liver transplantion and radiofrequency ablation are increasingly used for the curative treatment of HCC, however, the survival rate of HCC patients who have undergone curative resection remains unsatisfactory due to the high recurrence rate. HCC is a complex disease that is typically resistant to the most commonly used types of chemotherapy and radiotherapy; therefore, the development of novel treatment strategies is required to improve the survival rate of this disease. A high viral load of HBV DNA is the most important correctable risk factor for HCC recurrence, for example nucleos(t)ide analogs improve the outcome following curative resection of HBV-associated HCC, and interferon-α exhibits antitumor activity against various types of cancer via direct inhibitory effects on tumor cells, anti-angiogenesis, enhanced immunogenicity of tumors, immunomodulatory effects and liver dysfunction. In the present review, antiviral treatment for HBV-associated HCC is described as a strategy to reduce recurrence and improve survival.

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Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion

Kolovrat¹,

Gojkovic²,

Krezic³

et al. 2020

WJH

478

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Heparin-binding epidermal growth factor-like growth factor protects rat intestine after portal triad clamping

Cited by 3 publications

References 29 publications

The causal associations between growth factors and constipation: a two-sample Mendelian randomization study

The causal associations between growth factors and constipation: a two-sample Mendelian randomization study

Role of antiviral therapy in reducing recurrence and improving survival in hepatitis B virus-associated hepatocellular carcinoma following curative resection (Review)

Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion

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