Portable infrared lightbox for improving the detection limits of paper-based phosphate devices

Heidari-Bafroui, Hojat; Ribeiro, Brenno; Charbaji, Amer; Anagnostopoulos, C.; Faghri, Mohammad

doi:10.1016/j.measurement.2020.108607

Cited by 21 publications

(18 citation statements)

References 40 publications

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“…The recent advances in optoelectronics have enabled the fabrication of miniaturized thermoelectrically cooled (TEC) InGaAs photodiodes. [ 77–79 ] As a future direction for this work, we aim to construct portable and wearable NIR fluorescence detectors, capable of transducing the data to a smartphone, [ 80 ] by assembling a TEC InGaAs photodiode, an LED light source, and bandpass filters into portable and wearable platforms to enable point‐of‐care wound diagnostics. Furthermore, it is worth mentioning that hydrogen peroxide has been traditionally utilized for wound cleaning.…”

Section: Resultsmentioning

confidence: 99%

A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress

Safaee

Gravely

Roxbury

2021

Adv Funct Materials

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In an effort to facilitate personalized medical approaches, the continuous and noninvasive monitoring of biochemical information using wearable technologies can enable a detailed understanding of an individual's physiology. Reactive oxygen species (ROS) are a class of oxygen‐containing free radicals that function in a wide range of biological processes. In wound healing applications, the continuous monitoring of ROS through a wearable diagnostics platform is essential for the prevention of chronicity and pathogenic infection. Here, a versatile one‐step procedure is utilized to fabricate optical core‐shell microfibrous textiles incorporating single‐walled carbon nanotubes (SWCNTs) for the real‐time optical monitoring of hydrogen peroxide concentrations in in vitro wounds. The environmentally sensitive and non‐photobleachable fluorescence of SWCNTs enables continuous analyte monitoring without decay in signal over time. The existence of multiple chiralities of SWCNTs emitting near‐infrared fluorescence with narrow bandwidths allows a ratiometric signal readout invariant to the excitation source distance and exposure time. The individual fibers encapsulate the SWCNT nanosensors for at least 21 days without apparent loss in structural integrity. Moreover, the microfibrous textiles are utilized to spatially resolve peroxide concentrations using a camera and further integrated into commercial wound bandages without significant degradation in their optical properties.

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Section: Resultsmentioning

confidence: 99%

A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress

Safaee

Gravely

Roxbury

2021

Adv Funct Materials

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“…It is also very user-friendly and easy to use. The device can be easily incorporated into a portable imaging platform that allows the user to easily and reproducibly fold the device ( Figure 9 ) and then analyze results in the field similar to what has been developed in [ 55 , 56 , 57 ]. These platforms are suitable for use in the field as they do not require any external power supply and they directly interface with a smartphone to provide instantaneous quantitative results.…”

Section: Resultsmentioning

confidence: 99%

A New Paper-Based Microfluidic Device for Improved Detection of Nitrate in Water

Charbaji

Heidari-Bafroui

Anagnostopoulos

et al. 2020

Sensors

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In this paper, we report a simple and inexpensive paper-based microfluidic device for detecting nitrate in water. This device incorporates two recent developments in paper-based technology suitable for nitrate detection and has an optimized microfluidic design. The first technical advancement employed is an innovative fibrous composite material made up of cotton fibers and zinc microparticles that can be incorporated in paper-based devices and results in better nitrate reduction. The second is a detection zone with an immobilized reagent that allows the passage of a larger sample volume. Different acids were tested—citric and phosphoric acids gave better results than hydrochloric acid since this acid evaporates completely without leaving any residue behind on paper. Different microfluidic designs that utilize various fluid control technologies were investigated and a design with a folding detection zone was chosen and optimized to improve the uniformity of the signal produced. The optimized design allowed the device to achieve a limit of detection and quantification of 0.53 ppm and 1.18 ppm, respectively, for nitrate in water. This accounted for more than a 40% improvement on what has been previously realized for the detection of nitrate in water using paper-based technology.

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“…An inexpensive and portable lightbox was previously developed to improve the detection limits of paper-based devices for detecting phosphate [ 39 ]. This lightbox measures the absorbance of the molybdenum blue reaction in the infrared region since the peak absorbance of this reaction occurs in the infrared zone of the spectrum.…”

Section: Methodsmentioning

confidence: 99%

“…Figure 4. Schematic of the lightbox and its components that is wirelessly controlled by a smartphone to capture images of the detection zones in the infrared zone[39].…”

mentioning

confidence: 99%

A Colorimetric Dip Strip Assay for Detection of Low Concentrations of Phosphate in Seawater

Heidari-Bafroui

Charbaji

Anagnostopoulos

et al. 2021

Sensors

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Nutrient pollution remains one of the greatest threats to water quality and imposes numerous public health and ecological concerns. Phosphate, the most common form of phosphorus, is one of the key nutrients necessary for plant growth. However, phosphate concentration in water should be carefully monitored for environmental protection requirements. Hence, an easy-to-use, field-deployable, and reliable device is needed to measure phosphate concentrations in the field. In this study, an inexpensive dip strip is developed for the detection of low concentrations of phosphate in water and seawater. In this device, ascorbic acid/antimony reagent was dried on blotting paper, which served as the detection zone, and was followed by a wet chemistry protocol using the molybdenum method. Ammonium molybdate and sulfuric acid were separately stored in liquid form to significantly improve the lifetime of the device and enhance the reproducibility of its performance. The device was tested with deionized water and Sargasso Sea seawater. The limits of detection and quantification for the optimized device using a desktop scanner were 0.134 ppm and 0.472 ppm for phosphate in water and 0.438 ppm and 1.961 ppm in seawater, respectively. The use of the portable infrared lightbox previously developed at our lab improved the limits of detection and quantification by a factor of three and were 0.156 ppm and 0.769 ppm for the Sargasso Sea seawater. The device’s shelf life, storage conditions, and limit of detection are superior to what was previously reported for the paper-based phosphate detection devices.

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Portable infrared lightbox for improving the detection limits of paper-based phosphate devices

Cited by 21 publications

References 40 publications

A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress

A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress

A New Paper-Based Microfluidic Device for Improved Detection of Nitrate in Water

A Colorimetric Dip Strip Assay for Detection of Low Concentrations of Phosphate in Seawater

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