Portable electrospray ionization mass spectrometry (ESI-MS) for analysis of contaminants in the field

Janfelt, Christian; Græsbøll, Rune; Lauritsen, Frants Roager

doi:10.1080/03067319.2011.561341

Cited by 12 publications

(17 citation statements)

References 16 publications

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“…57 Other environmentally relevant analytes – amines, nitro compounds, and fluorinated compounds as well as other small organics - have been detected using the Mini 10 with a variety of non-ambient ionization techniques (ESI, DESI, electrosonic spray ionization, APCI, and membrane inlet with electron impact). 15,62,253 …”

Section: Practical Applicationsmentioning

confidence: 99%

Miniature and Fieldable Mass Spectrometers: Recent Advances

et al. 2015

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Section: Practical Applicationsmentioning

confidence: 99%

Miniature and Fieldable Mass Spectrometers: Recent Advances

et al. 2015

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“…256 PCR ESI-MS also has the advantage of working well with mixtures of organisms, with the identification of both species and the relative ratios of abundance usually determined. 256,257 As with MALDI-MS instruments, ESI-MS instruments tend to be large and expensive, but improvements in miniaturized ESI-MS units 258 and in amplification technologies offer the potential for PCR ESI-MS to be a rapid point-of-care diagnostic. The Iridica system from Abbott Molecular is currently on the market and is specifically designed for pathogen identification directly from patient samples although it is not yet available in the United States.…”

Section: Diagnostic Techniquesmentioning

confidence: 99%

Targeted treatment for bacterial infections: prospects for pathogen-specific antibiotics coupled with rapid diagnostics

Maxson

Mitchell

2016

Tetrahedron

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Antibiotics are a cornerstone of modern medicine and have significantly reduced the burden of infectious diseases. However, commonly used broad-spectrum antibiotics can cause major collateral damage to the human microbiome, causing complications ranging from antibiotic-associated colitis to the rapid spread of resistance. Employing narrower spectrum antibiotics targeting specific pathogens may alleviate this predicament as well as provide additional tools to expand an antibiotic repertoire threatened by the inevitability of resistance. Improvements in clinical diagnosis will be required to effectively utilize pathogen-specific antibiotics and new molecular diagnostics are poised to fulfill this need. Here we review recent trends and the future prospects of deploying narrower spectrum antibiotics coupled with rapid diagnostics. Further, we discuss the theoretical advantages and limitations of this emerging approach to controlling bacterial infectious diseases.

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“…These hurdles limited the applications of the widely used electrospray ionization (ESI) and desorption electrospray ionization (DESI) in miniature mass spectrometers. A portable ESI source was developed and successfully attached to a miniature MS instrument by Janfelt et al by using no syringe pump or gas flow, but the given stability of the ion signals was not satisfactory, and cell cleaning and sample varying is not easy in that device. In addition, the repetitive injection of the sample solution was probably implemented by the combination of the capillary force, electroosmotic flow effect, and gravity force; all of which are hard to manipulate so that the sampling rate was practically untunable.…”

Section: Introductionmentioning

confidence: 99%

Characterization and application of a self‐aspirating electrospray source with pneumatic‐assisted ionization

Zhang

et al. 2017

J. Mass Spectrom.

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A single gas-assisted electrospray ion source developed for ambient mass spectrometry is introduced in this paper. Simultaneous self-aspiration and electrospray could be achieved by using a constant sheath gas flow supplied from a mini air pump. A gas dynamic study of the spray module is carried out for structural optimization. The entire device exhibits a simplified design and has been systematically characterized through both simulated and experimental investigations. According to the results, the ion source exhibited satisfactory stability and the ability for quantitative operation in routine electrospray ionization mass spectrometry. Furthermore, the ion source can be operated as a desorption electrospray ionization source to perform direct desorption/ionization of the solid samples. The versatile source described here appears to provide a practical approach to perform ambient mass spectrometry analysis with unrestricted sampling operation, and the extensive gas dynamic studies together with the experimental characterization are believed to be helpful in building self-aspirating spray devices. Copyright © 2017 John Wiley & Sons, Ltd.

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Portable electrospray ionization mass spectrometry (ESI-MS) for analysis of contaminants in the field

Cited by 12 publications

References 16 publications

Miniature and Fieldable Mass Spectrometers: Recent Advances

Miniature and Fieldable Mass Spectrometers: Recent Advances

Targeted treatment for bacterial infections: prospects for pathogen-specific antibiotics coupled with rapid diagnostics

Characterization and application of a self‐aspirating electrospray source with pneumatic‐assisted ionization

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