Porphyromonas gulae sp. nov., an anaerobic, gram-negative coccobacillus from the gingival sulcus of various animal hosts.

Fournier, Dominique; Mouton, Christian; Lapierre, Pascal; Kato, Tsuyoshi; Okuda, K; Ménard, Christian

doi:10.1099/00207713-51-3-1179

Cited by 104 publications

(117 citation statements)

References 39 publications

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“…1993; Fournier et al, 2001;Mikkelsen et al, 2008). P. gingivalis, isolated from the human oral cavity, was reported to be a key pathogen in human periodontal disease (Hajishengallis et al, 2012), whereas P. gulae was reported to be the most relevant pathogen in feline periodontal disease (Perez-Salcedo et al, 2012) and has been isolated from gingivitis and mild periodontitis lesions in dogs (Davis et al, 2013) and a case of suppurative otitis and ascending meningoencephalitis in a captive Parma wallaby showing neurological signs (Giannitti et al, 2014).…”

mentioning

confidence: 99%

Porphyromonas loveana sp. nov., isolated from the oral cavity of Australian marsupials

Bird

Trott

Mikkelsen

et al. 2016

International Journal of Systematic and Evolutionary Microbiology

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An obligatory anaerobic, Gram-stain-negative coccobacillus with black-pigmented colonies was isolated from the oral cavity of selected Australian marsupial species. Phenotypic and molecular criteria showed that this bacterium was a distinct species within the genus Porphyromonas, and was closely related to Porphyromonas gingivalis and Porphyromonas gulae. This putative novel species and P. gulae could be differentiated from P. gingivalis by catalase activity. Further characterization by multi-locus enzyme electrophoresis of glutamate dehydrogenase and malate dehydrogenase enzyme mobility and matrix-assisted laser desorption ionization time-of-flight MS showed that this putative novel species could be differentiated phenotypically from P. gingivalis and P. gulae. Definitive identification by 16S rRNA gene sequencing showed that this bacterium belonged to a unique monophyletic lineage, phylogenetically distinct from P. gingivalis (94.9 % similarity) and P. gulae (95.5 %). This also was supported by 16S-23S rRNA intergenic spacer region and glutamate dehydrogenase gene sequencing. A new species epithet, Porphyromonas loveana sp. nov., is proposed for this bacterium, with DSM 28520 T (=NCTC 13658 T =UQD444 T =MRK101 T ), isolated from a musky rat kangaroo, as the type strain.

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mentioning

confidence: 99%

Porphyromonas loveana sp. nov., isolated from the oral cavity of Australian marsupials

Bird

Trott

Mikkelsen

et al. 2016

International Journal of Systematic and Evolutionary Microbiology

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“…Therefore, the organisms identified must be interpreted with caution and consequently the terminology “‐like species” is used as in previous reports (Duarte, Tezolin, Figueiredo, Feres, & Bastos, 2010; Rober, Quirynen, Haffajee, Schepers, & Teughels, 2008). Furthermore, bacterial species with genotypes different from the 300 present in HOMIM are not likely recognized, and bacteria recognized on the microarray may show phenotypes different from human bacteria (Fournier et al, 2001). …”

Section: Discussionmentioning

confidence: 99%

Ligature‐associated bacterial profiles are linked to type 2 diabetes mellitus in a rat model and influenced by antibody treatment against TNF‐α or RAGE

Grauballe

Belstrøm

Østergaard

et al. 2017

Clinical & Exp Dental Res

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There is a bidirectional relationship between periodontal disease (PD) and type 2 diabetes mellitus (T2D). T2D may lead to ecological perturbations in the oral environment, which may facilitate an altered microbiota. However, previous studies have been inconclusive in determining the effect of T2D on oral bacterial profiles. Therefore, we aimed to evaluate the influence of T2D on the ligature‐associated bacterial profile in a diabetic rat model with PD and investigated the impact of blocking inflammatory pathways with antibodies targeting either Tumor Necrosis Factor α (TNF‐α) or the receptor of advanced glycation end‐products (RAGE). A total of 62 Zucker obese rats (45 T2D) and 17 lean (non‐T2D) were divided into 4 treatment groups; lean with PD, obese with PD, obese with PD and anti‐TNF‐α treatment, and obese with PD with anti‐RAGE treatment. Periodontal disease was ligature induced. Ligature‐associated bacterial profiles were analyzed using Human Oral Microbe Identification Microarray (HOMIM). Ligature‐associated bacterial profiles differed between lean and obese rats. Furthermore, treatment with antibodies against TNF‐α or RAGE had an impact on subgingival bacterial profiles. T2D phenotypes are associated with different ligature‐associated bacterial profiles and influenced by treatment with antibodies against TNF‐α or RAGE.

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“…denticanis may prove to be an important periodontal pathogen in companion animals. Previous work by our group (Hardham et al, 2003(Hardham et al, , 2005a and others (Fournier et al, 2001) has indicated that the periodontal pathogens in companion animals may be slightly different from those of humans. For example, Porphyromonas gulae has been identified in companion animals (Fournier et al, 2001;Hardham et al, 2003Hardham et al, , 2005a, but not in humans.…”

Section: Mouse Model Of Periodontal Diseasementioning

confidence: 94%

Transfer of Bacteroides splanchnicus to Odoribacter gen. nov. as Odoribacter splanchnicus comb. nov., and description of Odoribacter denticanis sp. nov., isolated from the crevicular spaces of canine periodontitis patients

Hardham

King

Dreier

et al. 2008

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLO

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Porphyromonas gulae sp. nov., an anaerobic, gram-negative coccobacillus from the gingival sulcus of various animal hosts.

Cited by 104 publications

References 39 publications

Porphyromonas loveana sp. nov., isolated from the oral cavity of Australian marsupials

Porphyromonas loveana sp. nov., isolated from the oral cavity of Australian marsupials

Ligature‐associated bacterial profiles are linked to type 2 diabetes mellitus in a rat model and influenced by antibody treatment against TNF‐α or RAGE

Transfer of Bacteroides splanchnicus to Odoribacter gen. nov. as Odoribacter splanchnicus comb. nov., and description of Odoribacter denticanis sp. nov., isolated from the crevicular spaces of canine periodontitis patients

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