Porphyrin metabolism V. The metabolism of purines in experimental porphyria

The Biosynthesis and Interconversion of Purines and Their Derivatives1

“…A very recent report by Talman et al (195) concerning experimental porphyria in chick embryos induced by allylisopropylacetylcarbamide or allylisopropylacetamide (AIA) seems referable to interactions of the type discussed here. Under the conditions of experimental porphyria induced by AIA, uric acid synthesis is depressed.…”

Acute Intermittent Porphyria

“…The exogenous adm inistration of adenine revealed no abnorm alities in its utilization, thus suggesting th a t in porphyria the disturbance is in the synthesis of purines. Talman et al noted th at the adm inistration of adenine to porphyric chick embryos resulted in better development and a reduction of porphyrin excretion [13]. Gajdos and Gajdos-Torok, work ing with rats in which porphyria was induced by hexachlorobenzene, noted a similar beneficial effect following the adm inistration of adenosine 5-monophosphoric acid [4].…”

The nature of King James VI/I’s medical conditions: new approaches to the diagnosis

“…A description by De Mayerne (1623) of James’s urinary calculi as ‘red sand’ and ‘crumbly grains of sand’ is consistent with the formation of uric acid stones (Asplin, Coe and Favus, 1998; Gradwohl, 1938). It is noteworthy that acute porphyria is accompanied by a reduced blood level of uric acid (Nuki, 2000; Talman, Labbe, Aldrich and Sears, 1959; Taxay, 1961). The observation that James most probably had uric acid renal stones with nephropathy and clinical evidence of gout is further, albeit indirect, evidence that he did not suffer from acute porphyria.…”