Poroviscoelastic characterization of particle-reinforced gelatin gels using indentation and homogenization

Galli, Mattéo; Fornasiere, Elvis; Botsis, J.; Oyen, Michelle L.

doi:10.1016/j.jmbbm.2011.01.009

Cited by 40 publications

(33 citation statements)

References 44 publications

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“…40 Further, this explains why the hypothesized value of m u leads to direct variations in the obtained value of the drained Poisson's ratio m for bone [ Fig. 5(b)].…”

Section: Discussionmentioning

confidence: 92%

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Size effects in indentation of hydrated biological tissues

et al. 2011

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Fluid flow in biological tissues is important in both mechanical and biological contexts. Given the hierarchical nature of tissues, there are varying length scales at which time-dependent mechanical behavior due to fluid flow may be exhibited. Here, spherical nanoindentation and microindentation testings are used for the characterization of length scale effects in the mechanical response of hydrated tissues. Although elastic properties were consistent across length scales, there was a substantial difference between the time-dependent mechanical responses for large and small contact radii in the same tissue specimens. This difference was far more obvious when poroelastic analysis was used instead of viscoelastic analysis. Overall, indentation testing is a fast and robust technique for characterizing the hierarchical structure of biological materials from nanometer to micrometer length scales and is capable of making quantitative material property measurements to do with fluid flow.

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“…40 Further, this explains why the hypothesized value of m u leads to direct variations in the obtained value of the drained Poisson's ratio m for bone [ Fig. 5(b)].…”

Section: Discussionmentioning

confidence: 92%

“…This took the spherical microindentation data out of a linear poroelastic framework, and poroviscoelastic analysis would be required. 40 It is important to highlight that the magnitude of the time-dependent displacement is a function of the difference between m u and m, as can be seen by combining Eq. (9) with Eq.…”

Section: Discussionmentioning

confidence: 99%

Size effects in indentation of hydrated biological tissues

et al. 2011

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“…Inset shows the way λ ο was calculated demarcating the transition from Rouse modes to power law relaxation samples) and contributes to the terminal relaxation processes (Oyen 2013;Strange et al 2013;Wang et al 2014). Poroviscoelastic relaxation analysis has not received attention for gluten networks although some work is available in the literature for other biopolymer systems, as for instance for gelatin (Forte et al 2015;Galli et al 2011;Kalyanam et al 2009), alginate (Cai et al 2010), or fibrin gels (Noailly et al 2008). …”

Section: Continuous Relaxation Spectramentioning

confidence: 99%

Influence of supramolecular forces on the linear viscoelasticity of gluten

2016

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Stress relaxation behavior of hydrated gluten networks was investigated by means of rheometry combined with μ-computed tomography (μ-CT) imaging. Stress relaxation behavior was followed over a wide temperature range (0-70°C). Modulation of intermolecular bonds was achieved with urea or ascorbic acid in an effort to elucidate the presiding intermolecular interactions over gluten network relaxation. Master curves of viscoelasticity were constructed, and relaxation spectra were computed revealing three relaxation regimes for all samples. Relaxation commences with a welldefined short-time regime where Rouse-like modes dominate, followed by a power law region displaying continuous relaxation concluding in a terminal zone. In the latter zone, poroelastic relaxation due to water migration in the nanoporous structure of the network also contributes to the stress relief in the material. Hydrogen bonding between adjacent protein chains was identified as the determinant force that influences the relaxation of the networks. Changes in intermolecular interactions also resulted in changes in microstructure of the material that was also linked to the relaxation behavior of the networks.

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“…The relationship between fluid flow rate through a scaffold and the applied pressure is determined by permeability, as described by Darcy's law. 12 Alternative methods involve calculations based on pore size and geometrical modelling of the scaffold structure, 55 or measurement by spherical indentation tests, 56 but some prior knowledge of the scaffold behaviour is required.…”

Section: Existing Characterisation Techniquesmentioning

confidence: 99%

Quantitative architectural description of tissue engineering scaffolds

Ashworth

Best

Cameron

2014

Materials Technology

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Arguably one of the most specialised subtopics in porous materials research is that of tissue engineering scaffolds. The porous architecture of these scaffolds is a key variable in determining biological response. However, techniques for characterising these materials tend to vary widely in the literature. There is a need for a set of transferable and effective methods for architectural characterisation. In this review, four key areas of importance are addressed. First, the definition and interpretation of pore size are considered in relation to fluid transport properties, by analogy with filtration research. Second, the definition of interconnectivity is discussed using insight obtained from cement and concrete research. Third, the issue of data scalability is addressed by consideration of percolation theory, as implemented for the study of geological materials. Finally, emerging techniques such as confocal and multiphoton microscopy are discussed. These methods allow the three-dimensional observation of pore strut arrangement, as well holding great potential for understanding changes in pore architecture under dynamic conditions.

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Poroviscoelastic characterization of particle-reinforced gelatin gels using indentation and homogenization

Cited by 40 publications

References 44 publications

Size effects in indentation of hydrated biological tissues

Size effects in indentation of hydrated biological tissues

Influence of supramolecular forces on the linear viscoelasticity of gluten

Quantitative architectural description of tissue engineering scaffolds

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