Porous-Type Tracheal Prosthesis Sealed With Collagen Sponge

Teramachi, Masayoshi; Nakamura, Tatsuo; Yamamoto, Yasumichi; Kiyotani, Tetsuya; Takimoto, Yukinobu; Shimizu, Yasuhiko

doi:10.1016/s0003-4975(97)00755-8

Cited by 71 publications

(31 citation statements)

References 19 publications

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“…Collagen sponges have been widely used as scaffolds for cell transplantation, and this material is already in clinical use (Teramachi et al 1997). In addition, bFGF is known to promote neovascularization, which is necessary for cell survival, tissue restoration, and maturation of regenerating tissues (Masaki et al 2002).…”

Section: Recovery From Stroke By Grafting Neurosphere-like Spheres Dementioning

confidence: 99%

Mesenchymal cell populations: development of the induction systems for Schwann cells and neuronal cells and finding the unique stem cell population

Kitada

2012

Anat Sci Int

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Mesenchymal cell populations, referred to as mesenchymal stem cells or multipotent stromal cells (MSCs), which include bone marrow stromal cells (BMSCs), umbilical cord stromal cells and adipose stromal cells (ASCs), participate in tissue repair when transplanted into damaged or degenerating tissues. The trophic support and immunomodulation provided by MSCs can protect against tissue damage, and the differentiation potential of these cells may help to replace lost cells. MSCs are easily accessible and can be expanded on a large scale. In addition, BMSCs and ASCs can be harvested from the patient himself. Thus, MSCs are considered promising candidates for cell therapy. In this review, I will discuss recently discovered high-efficiency induction systems for deriving Schwann cells and neurons from MSCs. Other features of MSCs that are important for tissue repair include the self-renewing property of stem cells and their potential for differentiation. Thus, I will also discuss the stemness of MSCs and describe the discovery of a certain stem cell type among adult MSCs that can self-renew and differentiate into cells of all three germ layers. Furthermore, I will explore the prospects of using this cell population for cell therapy.

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Section: Recovery From Stroke By Grafting Neurosphere-like Spheres Dementioning

confidence: 99%

Mesenchymal cell populations: development of the induction systems for Schwann cells and neuronal cells and finding the unique stem cell population

Kitada

2012

Anat Sci Int

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“…Collagen-coated polypropylene mesh reinforced with a polypropylene mesh cylinder is a trachea prosthetic that has been extensively studied. 53,54,57,[60][61][62][63][64]73,77,80,81,88,104 There have also been many alterations to the basic collagen/polypropylene scaffold, by adding a cell-loaded collagen gel to the outer surface of the construct, 57,80 coating vitrigel on the epithelium, 81 and coating poly (L-lactic acid-co-e-caprolactone) on the lumen. 73 Coating scaffolds with peptides, like the RGD cell adhesion ligand, is another approach used to enhance cell attachment.…”

Section: Combination Of Materialsmentioning

confidence: 99%

Overview of Tracheal Tissue Engineering: Clinical Need Drives the Laboratory Approach

2011

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Breathing is a natural function that most of us do not even think about, but for those who suffer from disease or damage of the trachea, the obstruction of breathing can mean severe restrictions to quality of life or may even be fatal. Replacement and reconstruction of the trachea is one of the most difficult procedures in otolaryngology/head and neck surgery, and also one of the most vital. Previous reviews have focused primarily on clinical perspectives or instead on engineering strategies. However, the current review endeavors to bridge this gap by evaluating engineering approaches in a practical clinical context. For example, although contemporary approaches often include in vitro bioreactor pre-culture, or sub-cutaneous in vivo conditioning, the limitations they present in terms of regulatory approval, cost, additional surgery, and/or risk of infection challenge engineers to develop the next generation of biodegradable/resorbable biomaterials that can be directly implanted in situ. Essentially, the functionality of the replacement is the most important requirement. It must be the correct shape and size, achieve an airtight fit, resist collapse as it is replaced by new tissue, and be non-immunogenic. As we look to the future, there will be no one-size-fits-all solution.

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“…Initial steps towards generating a functional airway using collagen sponges in conjunction with a stent or synthetic scaffolds were discouraged due to high rate of graft failure, infections and dissociation of the tissue. [1][2][3][4] In 2008, great optimism, enthusiasm and worldwide attention were gained for the first tissueengineered trachea transplantation by Macchiarini et al 5 The patient was a 30-year-old woman who suffered from a hypoplastic left main bronchus due to pulmonary tuberculosis. Repetitive stenting appeared unsuccessful and led to recurring pneumonitis.…”

Section: Introductionmentioning

confidence: 99%

Tissue Engineering of the Trachea: What is the Hold-up?

Siddiqi¹,

Wit²,

Timman³

et al. 2017

MOJCSR

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Tissue-engineering of the trachea is called for based on the clinical consequences of airway pathology. Recent years have witnessed various reports from the tissueengineering field including a few cases of clinical patients receiving an engineered airway. Multiple fields have accelerated in parallel with the concept of tissue decellularization, isolation of stem cells and possible insights in the biology of different stem cells. Yet, a clinical trial using a tissue-engineered trachea is yet to be initiated. What is the hold-up? Are the hurdles predominantly in the matrix field or cellular regeneration field or both? This systematic review is an attempt to evoke question on what the hold-up might be in the journey of successful regeneration of a functional airway.

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Porous-Type Tracheal Prosthesis Sealed With Collagen Sponge

Cited by 71 publications

References 19 publications

Mesenchymal cell populations: development of the induction systems for Schwann cells and neuronal cells and finding the unique stem cell population

Mesenchymal cell populations: development of the induction systems for Schwann cells and neuronal cells and finding the unique stem cell population

Overview of Tracheal Tissue Engineering: Clinical Need Drives the Laboratory Approach

Tissue Engineering of the Trachea: What is the Hold-up?

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