Porous Structure Design in Tissue Engineering Using Anisotropic Radial Basis Functions

Guo, Ye; Liu, Ke; Yu, Zeyun

doi:10.1007/978-3-030-03801-4_8

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…The interconnected porous structure not only facilitates the inflow of nutrients and the export of metabolic waste but also provides good conditions for cell growth and attachment. Additionally, stress shielding can be avoided to a certain extent when porous structures are used instead of solid structures [ 13 ]. It is worth noting that porous structures have a variety of design methods, and that a cellular structure is a kind of porous structure designed in the early stage, such as honeycombs.…”

Section: Review Of the Design Of The Bone Joint Replacementmentioning

confidence: 99%

A Critical Review of the Design, Manufacture, and Evaluation of Bone Joint Replacements for Bone Repair

et al. 2021

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With the change of people’s living habits, bone trauma has become a common clinical disease. A large number of bone joint replacements is performed every year around the world. Bone joint replacement is a major approach for restoring the functionalities of human joints caused by bone traumas or some chronic bone diseases. However, the current bone joint replacement products still cannot meet the increasing demands and there is still room to increase the performance of the current products. The structural design of the implant is crucial because the performance of the implant relies heavily on its geometry and microarchitecture. Bionic design learning from the natural structure is widely used. With the progress of technology, machine learning can be used to optimize the structure of bone implants, which may become the focus of research in the future. In addition, the optimization of the microstructure of bone implants also has an important impact on its performance. The widely used design algorithm for the optimization of bone joint replacements is reviewed in the present study. Regarding the manufacturing of the implant, the emerging additive manufacturing technique provides more room for the design of complex microstructures. The additive manufacturing technique has enabled the production of bone joint replacements with more complex internal structures, which makes the design process more convenient. Numerical modeling plays an important role in the evaluation of the performance of an implant. For example, theoretical and numerical analysis can be carried out by establishing a musculoskeletal model to prepare for the practical use of bone implants. Besides, the in vitro and in vivo testing can provide mechanical properties of bone implants that are more in line with the implant recipient’s situation. In the present study, the progress of the design, manufacture, and evaluation of the orthopedic implant, especially the joint replacement, is critically reviewed.

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Section: Review Of the Design Of The Bone Joint Replacementmentioning

confidence: 99%

A Critical Review of the Design, Manufacture, and Evaluation of Bone Joint Replacements for Bone Repair

et al. 2021

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“…The interconnected porous structure not only facilitates the inflow of nutrients and the treatment of metabolic waste, but also provides good conditions for cell growth and attachment. Additionally, the stress shielding can be avoided to a certain extent when the porous structures are used instead of the solid structures ( Guo et al, 2018 ). An example of designing the femur scaffold using the porous microstructures is shown in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

“… An example of designing the scaffold using the porous microstructure (adapted from Guo et al, 2018 ). …”

Section: Introductionmentioning

confidence: 99%

A Critical Review on the Design, Manufacturing and Assessment of the Bone Scaffold for Large Bone Defects

Huo

Lü

Meng

et al. 2021

Front. Bioeng. Biotechnol.

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In recent years, bone tissue engineering has emerged as a promising solution for large bone defects. Additionally, the emergence and development of the smart metamaterial, the advanced optimization algorithm, the advanced manufacturing technique, etc. have largely changed the way how the bone scaffold is designed, manufactured and assessed. Therefore, the aim of the present study was to give an up-to-date review on the design, manufacturing and assessment of the bone scaffold for large bone defects. The following parts are thoroughly reviewed: 1) the design of the microstructure of the bone scaffold, 2) the application of the metamaterial in the design of bone scaffold, 3) the optimization of the microstructure of the bone scaffold, 4) the advanced manufacturing of the bone scaffold, 5) the techniques for assessing the performance of bone scaffolds.

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Porous Structure Design in Tissue Engineering Using Anisotropic Radial Basis Functions

Cited by 2 publications

References 23 publications

A Critical Review of the Design, Manufacture, and Evaluation of Bone Joint Replacements for Bone Repair

A Critical Review of the Design, Manufacture, and Evaluation of Bone Joint Replacements for Bone Repair

A Critical Review on the Design, Manufacturing and Assessment of the Bone Scaffold for Large Bone Defects

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