Porous polysulfone coatings for enhanced drug delivery

Abstract

The synthesis of a porous polysulfone (PSU) coating for use in drug delivery applications is presented. PSU can serve as a functional surface coating for drug delivery vehicles, such as intraocular biomicrorobots. The coatings can be applied using spin coating or dip coating. The porosity is introduced by selectively dissolving calcium carbonate nanoparticles embedded in the bulk polymer. The network of pores thus formed increases by a factor of thirty the amount of Rhodamine B (model drug) that can be loaded and by a factor of fifteen the amount that can be released. The films do not affect cell viability and exhibit poor cell adhesion. The straightforward synthesis and predictability of porosity enables the tuning of the amount of drug that can be loaded.

Dumbbell Fluidic Tweezers for Dynamical Trapping and Selective Transport of Microobjects

“…Frequently, these tasks require not only precise and controlled locomotion of the microrobot but also its capability of cargo transport in biofluidic environments. To this end, two common strategies have been exploited: directly pushing objects with or loading them on the microrobot itself, and trapping objects in microflows/microvortices induced by the motion of the microrobot . The former strategy, generally referred to as contact manipulation, has been extensively reported in the literature.…”

Ionic transport processes in polymer mixture solutions based on quaternized polysulfones

“…Polysulfones, produced through polycondensation, are known as high-performance materials with superior thermal, chemical, and mechanical properties, which represents an advantage for many applications, such as filtration membranes [28][29][30][31][32], coatings [33,34], composites [35][36][37], microelectronic devices [38], thin film technology [39], biomaterials [25,37,40], and fuel cells [41][42][43][44]. Introduction of functional groups into polysulfones solves some limitations, and also extends the range of potential applications of these high-performance materials through the specific properties gained, and thus provides wider scope.…”

Thermoresponsive Microspheres as Smart Pore Plugs: Self‐Venting Clothing Membranes for Smart Outdoor Textiles

“…The overall porosity can be adjusted by the template content, the pore size by the size of the template particles and even asymmetric membrane structures are accessible . Process scale up today affords industrial membranes for water filtration, green textiles and has been investigated for drug delivery …”