Developing microrobots for precisely manipulating micro/nanoscale objects has triggered tremendous research interest for various applications in biology, chemistry, physics, and engineering. Here, a novel hypersonicâinduced hydrodynamic tweezers (HSHTs), which use gigahertz nanoâelectromechanical resonator to create localized 3D vortex streaming array for the capture and manipulation of microâ and nanoparticles in three orientations: transportation in a plane and selfârotation in place, are presented. 3D vortex streaming can effectively pick up particles from the flow, whereas the highâspeed rotating vortices are used to drive selfârotation simultaneously. By tuning flow rate, the captured particles can be delivered, queued, and selectively sorted through the 3D HSHTs. Through numerical simulations and theoretical analysis, the generation of the 3D vortex and the mechanism of the particles manipulation by ultrahigh frequency acoustic wave are demonstrated. Benefitting from the advantages of the acoustic and hydrodynamic method, the developed HSHTs work in a precise, noninvasive, labelâfree, and contactâfree manner, enabling wide applications in micro/nanoscale manipulations and biomedical research.