Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Elbadawi, Moe

doi:10.5185/amlett.2017.7063

Cited by 3 publications

(2 citation statements)

References 365 publications

(502 reference statements)

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“…The morphology presented with an appearance that is similar to the initial stage of sintering, despite using high temperatures. Increasing the sintering temperatures to 1250 and 1300°C proceeded to densify the scaffolds, however, complete densification was not attained, as previously achieved by the author . Nevertheless, it was evident that the improved compressive strengths with increasing sintering temperature was a reflection of the microstructural densification.…”

Section: Resultssupporting

confidence: 56%

“…Scaffold bulk porosity was measured using the helium pycnometer described in Section 2.3.1. The protocol used and the derived porosity calculation has been previously detailed . Compression tests were carried out using a universal testing machine (Roell, Zwick, UK) fitted with a 20 kN load cell (Xforce K, Zwick; 0.5% resolution) at a rate of 1 mm/min.…”

Section: Methodsmentioning

confidence: 99%

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Porous hydroxyapatite‐bioactive glass hybrid scaffolds fabricated via ceramic honeycomb extrusion

2018

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The successful fabrication of hydroxyapatite-bioactive glass scaffolds using honeycomb extrusion is presented herein. Hydroxyapatite was combined with either 10 wt% stoichiometric Bioglass â (BG1), calcium-excess Bioglass â (BG2) or canasite (CAN). For all composite materials, glass-induced partial phase transformation of the HA into the mechanically weaker b-tricalcium phosphate (TCP) occurred but XRD data demonstrated that BG2 exhibited a lower volume fraction of TCP than BG1. Consequently, the maximum compressive strength observed for BG1 and BG2 were 30.3 AE 3.9 and 56.7 AE 6.9 MPa, respectively, for specimens sintered at 1300°C. CAN scaffolds, in contrast, collapsed when handled when sintered below 1300°C, and thus failed. The microstructure illustrated a morphology similar to that of BG1 sintered at 1200°C, and hence a comparable compressive strength (11.4 AE 3.1 MPa). The results highlight the great potential offered by honeycomb extrusion for fabricating high-strength porous scaffolds. The compressive strengths exceed that of commercial scaffolds, and biological tests revealed an increase in cell viability over 7 days for all hybrid scaffolds. Thus it is expected that the incorporation of 10 wt% bioactive glass will provide the added advantage of enhanced bioactivity in concert with improved mechanical stability. K E Y W O R D SBioglass, canasite, composite, honeycomb extrusion, hydroxyapatite, scaffold

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Section: Resultssupporting

confidence: 56%

Section: Methodsmentioning

confidence: 99%