High strength yttria-reinforced HA scaffolds fabricated via honeycomb ceramic extrusion

Elbadawi, Moe; Shbeh, Mohammed

doi:10.1016/j.jmbbm.2017.10.009

Cited by 8 publications

(3 citation statements)

References 65 publications

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“…Ceramic honeycomb extrusion has been demonstrated to produce porous scaffolds with remarkable compressive strengths, and this study provides further credence thereto. The compressive strengths recorded herein are considerably greater than pure HA scaffolds that are commercially available, such as the BGS Endobon ® .…”

Section: Resultssupporting

confidence: 65%

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Porous hydroxyapatite‐bioactive glass hybrid scaffolds fabricated via ceramic honeycomb extrusion

2018

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The successful fabrication of hydroxyapatite-bioactive glass scaffolds using honeycomb extrusion is presented herein. Hydroxyapatite was combined with either 10 wt% stoichiometric Bioglass â (BG1), calcium-excess Bioglass â (BG2) or canasite (CAN). For all composite materials, glass-induced partial phase transformation of the HA into the mechanically weaker b-tricalcium phosphate (TCP) occurred but XRD data demonstrated that BG2 exhibited a lower volume fraction of TCP than BG1. Consequently, the maximum compressive strength observed for BG1 and BG2 were 30.3 AE 3.9 and 56.7 AE 6.9 MPa, respectively, for specimens sintered at 1300°C. CAN scaffolds, in contrast, collapsed when handled when sintered below 1300°C, and thus failed. The microstructure illustrated a morphology similar to that of BG1 sintered at 1200°C, and hence a comparable compressive strength (11.4 AE 3.1 MPa). The results highlight the great potential offered by honeycomb extrusion for fabricating high-strength porous scaffolds. The compressive strengths exceed that of commercial scaffolds, and biological tests revealed an increase in cell viability over 7 days for all hybrid scaffolds. Thus it is expected that the incorporation of 10 wt% bioactive glass will provide the added advantage of enhanced bioactivity in concert with improved mechanical stability. K E Y W O R D SBioglass, canasite, composite, honeycomb extrusion, hydroxyapatite, scaffold

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Section: Resultssupporting

confidence: 65%

“…It should be remarked that the compressive strengths obtained herein were lower than what has been obtained for pure HA scaffolds by extrusion . This decrease was attributed to the presence of β‐TCP, where the addition thereof to HA has been reported to mechanically weaken scaffolds .…”

Section: Resultscontrasting

confidence: 59%

Porous hydroxyapatite‐bioactive glass hybrid scaffolds fabricated via ceramic honeycomb extrusion

2018

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“…In our previous study, the extrusion method, which has been widely used to manufacture honeycomb ceramics for application in catalyst support, regenerator and filter, and so on, was first introduced into the fabrication of honeycomb β‐TCP bioceramic scaffolds (Feng, He, & Ye, ). Besides, Elbadawi and Shbeh () and Elbadawi, Wally, and Reaney () prepared porous hydroxyapatite‐bioactive glass hybrid scaffolds and yttria‐reinforced hydroxyapatite scaffolds by extrusion method. The honeycomb bioceramics prepared by extrusion are characterized by high production, unidirectional channel‐like macropores, controllable pore structures, and good mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

Enhanced osteogenesis of honeycomb β‐tricalcium phosphate scaffold by construction of interconnected pore structure: An in vivo study

Feng

et al. 2019

J Biomedical Materials Res

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Pore structure plays an important role in the in vivo osteogenesis for bone repair materials. In this study, honeycomb β-tricalcium phosphate (β-TCP) scaffolds were prepared by extrusion method, and gelatin microspheres were used as porogens to modify the pore structure of the scaffolds. The honeycomb β-TCP scaffolds were characterized by channel-like square macropores and unidirectional interconnection.To improve the pore interconnectivity of the scaffold, the spherical pores were formed in the channel walls by burning off the gelatin microspheres. Compared with unidirectional honeycomb β-TCP scaffold, the honeycomb β-TCP scaffold with interconnected pore structure had significantly higher porosity and faster degradation rate, at the expense of the mechanical strength. The in vivo assessment results demonstrated excellent osteogenesis of the honeycomb scaffolds. Moreover, the honeycomb β-TCP scaffold with interconnected pore structure markedly promoted new bone formation in comparison with the unidirectional honeycomb β-TCP scaffold.This work provides a new approach to prepare scaffolds with interconnected pore structure, and the honeycomb β-TCP scaffold with interconnected pore structure is expected to serve as an efficient bone repair material.

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Fabrication of complex shaped ceramic articles from 3D printed polylactic acid templates by replication process

Mamatha

Biswas

Das

et al. 2019

Ceramics International

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High strength yttria-reinforced HA scaffolds fabricated via honeycomb ceramic extrusion

Cited by 8 publications

References 65 publications

Porous hydroxyapatite‐bioactive glass hybrid scaffolds fabricated via ceramic honeycomb extrusion

Porous hydroxyapatite‐bioactive glass hybrid scaffolds fabricated via ceramic honeycomb extrusion

Enhanced osteogenesis of honeycomb β‐tricalcium phosphate scaffold by construction of interconnected pore structure: An in vivo study

Fabrication of complex shaped ceramic articles from 3D printed polylactic acid templates by replication process

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