Porous Gelatin-Alginate-Polyacrylamide Scaffolds with Interpenetrating Network Structure: Synthesis and Characterization

Several photo-curable hybrid systems based on methacrylate-modified camelina oil (CO) were synthesized through a copolymerization reaction with hydrophilic dimethacrylated poly(ethylene glycol) macromonomers (PEG MW ¼ 300, 550, and 750 g/mol). In a first step, the epoxidation and subsequently the methacrylation reactions of CO were performed and monitorized using 1 H NMR and FTIR. Further, the polymerization reaction of the new synthesized oil-based monomer under visible light was proved by FTIR. The chain length of methacrylate functionalized PEG was found to directly influence some key properties of the oil-based networks. The curing performance of the systems was studied by GF measurements. Water uptake capacity tests and contact angle measurements were undertaken and it was found that the internal arrangement of components is strongly affecting the hydrophilicity of the materials. Furthermore, nanostructured polyhedral oligomeric silsesquioxane (POSS) compounds bearing one or eight methacrylated groups were selected in order to obtain innovative organic-inorganic nanocomposites. Mechanical and thermal properties were evaluated by compression tests, DMA, TGA, and also the morphology of the synthesized materials was investigated by SEM.Practical applications: Tailoring the copolymer composition and the reinforcing agent in the manufacturing process leads to a wide range of products with optimum properties suitable for use in a variety of industrial areas. Well-defined oil-derived systems with controllable compressive strength were prepared in this work covering the whole range, from a hard material (with short chain PEG) to a soft and flexible one (with long chain PEG).

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“…The swelling degree (SD) was determined according to the Eq. :

SD (%) = \frac{w_{t} - w_{0}}{w_{0}} \times 100

where w t and w 0 represent the weights of swollen and dried state samples, respectively.…”

Section: Methodsmentioning

confidence: 99%

Hybrid nanocomposites based on POSS and networks of methacrylated camelina oil and various PEG derivatives

Bãlãnucã

Lungu

Hanganu

et al. 2014

Euro J Lipid Sci & Tech

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“…After extraction, the gel fraction percentages (GF %) of the samples were calculated using eqn (1):

G F % = \frac{w_{1}}{w_{0}} \times 100

where w 0 and w 1 represent the initial weights of the cured samples (before Soxhlet extraction) and the insoluble part (after Soxhlet extraction). The experiment was performed in triplicate.…”

Section: Methodsmentioning

confidence: 99%

Novel bio‐based IPNs obtained by simultaneous thermal polymerization of flexible methacrylate network based on a vegetable oil and a rigid epoxy

Bãlãnucã

Lungu

Conicov

et al. 2014

Polymers for Advanced Techs

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A series of novel vegetable oil-based interpenetrating polymer networks (IPNs) have been successfully prepared: on one hand, methacrylated camelina oil (MCO) and a polyethyleneglycol dimethacrylate (PEG, MW 750 g/mol) and on the other hand, diglycidylether of bisphenol A (DER), in various blend ratios (75/25, 50/50, and 25/75 wt). Hence the appealing innovative direction of the current work was to build oil-based poly(methacrylate) network using PEG macromonomer which is able to modulate adequately the crosslinking degree of the oil-based network.These innovative combinations of cross-linkable resins in terms of flexible methacrylate network based on camelina oil (CO) and PEG and a rigid epoxy (DER) were simultaneously polymerized using two independent noninterfering curing reactions: free-radical process for MCO and anionic polymerization of epoxy resin in the presence of a tertiary amine. The effect of the IPNs composition compositional characteristics on the reactivity of methacrylate or epoxy groups was studied using differential scanning calorimetry. The influence of the MCO-PEG bio-based polymer on the system properties was evaluated after curing by dynamic mechanical and thermogravimetric analyses. In addition mechanical and morphological studies were also carried out. The results suggested that blending of MCO and DER gave synergistic effects on the overall properties of the developed oil-based IPNs and a dependence on the methacrylate/epoxy ratio was clearly noticed.

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“…Cell culture Both gelatin and GelMA are well investigated materials for tissue engineering applications and were often used in order to induce cell adherence in various systems [3,6,10,11,25,27,28]. The biocompatibility of the synthesized materials was evaluated in terms of cell viability using freeze-dried scaffolds.…”

Section: Drug Release Profilementioning

confidence: 99%

“…The use of gelatin as wound dressing has been limited due to its solubility in aqueous media, poor thermal and mechanical behavior. Gelatin's methacryloyl derivative has been obtained through the direct reaction with the methacrylic anhydride, as first reported by Van Den Bulcke et al [5], and it is currently used to obtain simulated physiological microenvironments [6][7][8][9][10]. Methacryloyl gelatin (GelMA) can be further polymerized similarly to a synthetic monomer, leading to biocompatible, mechanically and thermally stable, insoluble materials with tunable properties (e.g: porosity, degradability, water uptake capacity) [3].…”

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confidence: 99%

Bicomponent Hydrogels Based on Methacryloyl Derivatives of Gelatin and Mucin with Potential Wound Dressing Applications

Serafim¹,

Olăreţ²,

Cecoltan³

et al. 2018

Mat.Plast.

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The present paper reports the first attempt to synthesize bicomponent hydrogels based on methacryloyl derivatives of gelatin (GelMA) and mucin (MuMA) with different compositions, with potential as wound dressings. While gelatin is widely investigated and used to fabricate scaffolds and coatings stimulating cell interactions and tissue regeneration, mucin - a macromolecule which covers the wet epithelia - remains yet under exploited as biomaterial. The influence of MuMA content on various parameters such as the affinity for aqueous media, stability in simulated physiologic media and the rheologic behavior was investigated. Also, the preliminary assessment of the drug release potential and biocompatibility were performed. The materials� water uptake capacity and rheologic behavior depend on the pH value of the incubation media, while their composition influences the drug release capacity and cells-scaffold interactions.

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Porous Gelatin-Alginate-Polyacrylamide Scaffolds with Interpenetrating Network Structure: Synthesis and Characterization

Cited by 27 publications

References 30 publications

Hybrid nanocomposites based on POSS and networks of methacrylated camelina oil and various PEG derivatives

Hybrid nanocomposites based on POSS and networks of methacrylated camelina oil and various PEG derivatives

Novel bio‐based IPNs obtained by simultaneous thermal polymerization of flexible methacrylate network based on a vegetable oil and a rigid epoxy

Bicomponent Hydrogels Based on Methacryloyl Derivatives of Gelatin and Mucin with Potential Wound Dressing Applications

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