Porous electrospun polycaprolactone (PCL) fibres by phase separation

Katsogiannis, Konstantinos Alexandros G.; Vladisavljević, Goran T.; Georgiadou, Stella

doi:10.1016/j.eurpolymj.2015.01.028

Cited by 218 publications

(175 citation statements)

References 28 publications

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“…This result could be explained based on the MeOH physico‐chemical properties as higher dielectric constant (32.7) than DCM (9.1) and differences in the boiling point of 65°C and 40°C, respectively. These could cause higher charge density in the polymer solution, which is essential for the nanofiber formation and phase separation . Small changes in the PCL nanofibers' ATR‐FTIR spectra compared with Bix‐PCL1 and Bix‐PCL2 nanofibers were observed.…”

Section: Resultsmentioning

confidence: 96%

Efficient cutaneous wound healing using bixin-loaded PCL nanofibers in diabetic mice

Pinzón-García

Cassini‐Vieira

Ribeiro

et al. 2016

J. Biomed. Mater. Res.

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The present work demonstrated an efficient cutaneous wound healing using Bixin-loaded polycaprolactone (PCL) nanofibers as a controlled delivery system. The influence of Bixin (Bix) content on PCL nanofiber, Bix-PCL1(2.5% w/w bix) and Bix-PCL2 (12.5% w/w bix) formation was investigated using electrical conductivity, attenuated total reflectance infrared spectroscopy, X-ray diffraction, thermal analysis, and scanning electronic microscopy. The results showed that a greater bixin concentration resulted in higher polymeric solution electrical conductivity. Moreover, higher polymeric solution electrical conductivity provides lower nanofibers in terms of average diameter than pure PCL nanofibers. In vitro release was largely governed by a diffusion-controlled mechanism. The initial Bixin release domain showed a burst release over the first 10 hours where approximately 30% and 40% of Bixin was released from Bix-PCL1 and Bix-PCL2 nanofibers, respectively. The second kinetic domain was comprised of a continuous and slow Bixin release that led to almost 100% of the Bixin being released within 14 days. The results on excisional wound model in induced diabetic mice indicated that the low concentration of Bixin released from loaded Bix-PCL nanofibers maintain the biological activity of Bixin and is efficient in accelerating the wound healing as well as in reducing the scar tissue area compared with pure PCL nanofibers. Therefore, soft material Bixin-loaded PCL nanofibers are a promising candidate for use in wound dressing. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1938-1949, 2017.

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Section: Resultsmentioning

confidence: 96%

Efficient cutaneous wound healing using bixin-loaded PCL nanofibers in diabetic mice

Pinzón-García

Cassini‐Vieira

Ribeiro

et al. 2016

J. Biomed. Mater. Res.

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“…Solvent volatility and evaporation rate are of particular importance to produce uniform fiber diameter and regular morphology of core–shell fibers. Katsogiannis et al [65] describe solvent mixtures of chloroform, dichloromethane, tetrahydrofuran, and formic acid with DMSO to produce PCL fibers with a porous structure. Volatile solvents have faster evaporation rates than DMSO.…”

Section: Coaxial Fiber Design Considerations For Sustained Releasementioning

confidence: 99%

Current strategies for sustaining drug release from electrospun nanofibers

Chou

Carson

Woodrow

2015

Journal of Controlled Release

408

269

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Electrospun drug-eluting fibers are emerging as a novel dosage form for multipurpose prevention against sexually transmitted infections, including HIV, and unintended pregnancy. Previous work from our lab and others show the versatility of this platform to deliver large doses of physico-chemically diverse agents. However, there is still an unmet need to develop practical fiber formulations for water-soluble small molecule drugs needed at high dosing due to intrinsic low potency or desire for sustained prevention. To date, most sustained release fibers have been restricted to the delivery of biologics or hydrophobic small molecules at low drug loading of typically < 1 wt.%, which is often impractical for most clinical applications. For hydrophilic small molecule drugs, their high aqueous solubility and poor partitioning and incompatibility with insoluble polymers make long-term release even more challenging. Here we investigate several existing strategies to sustain release of hydrophilic small molecule drugs that are highly-loaded in electrospun fibers. In particular, we investigate what is known about the design constraints required to realize multi-day release from fibers fabricated from uniaxial and coaxial electrospinning.

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“…Although it has been explored for solution, blend and emulsion electrospinning, in-situ structuring of PCL fibers has only recently been under investigation 19, 20, 27, 28 . However, elaborated investigations are required to advance the understanding of the pore formation mechanism during fiber formation.…”

Section: Introductionmentioning

confidence: 99%

Steering surface topographies of electrospun fibers: understanding the mechanisms

Yazgan

Dmitriev

Tyagi

et al. 2017

Sci Rep

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A profound understanding of how to tailor surface topographies of electrospun fibers is of great importance for surface sensitive applications including optical sensing, catalysis, drug delivery and tissue engineering. Hereby, a novel approach to comprehend the driving forces for fiber surface topography formation is introduced through inclusion of the dynamic solvent-polymer interaction during fiber formation. Thus, the interplay between polymer solubility as well as computed fiber jet surface temperature changes in function of time during solvent evaporation and the resultant phase separation behavior are studied. The correlation of experimental and theoretical results shows that the temperature difference between the polymer solution jet surface temperature and the dew point of the controlled electrospinning environment are the main influencing factors with respect to water condensation and thus phase separation leading to the final fiber surface topography. As polymer matrices with enhanced surface area are particularly appealing for sensing applications, we further functionalized our nanoporous fibrous membranes with a phosphorescent oxygen-sensitive dye. The hybrid membranes possess high brightness, stability in aqueous medium, linear response to oxygen and hence represent a promising scaffold for cell growth, contactless monitoring of oxygen and live fluorescence imaging in 3-D cell models.

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Porous electrospun polycaprolactone (PCL) fibres by phase separation

Cited by 218 publications

References 28 publications

Efficient cutaneous wound healing using bixin-loaded PCL nanofibers in diabetic mice

Efficient cutaneous wound healing using bixin-loaded PCL nanofibers in diabetic mice

Current strategies for sustaining drug release from electrospun nanofibers

Steering surface topographies of electrospun fibers: understanding the mechanisms

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